DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-5 and Hspa5

DIOPT Version :9

Sequence 1:NP_001286414.1 Gene:Hsc70-5 / 36583 FlyBaseID:FBgn0001220 Length:686 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:644 Identity:318/644 - (49%)
Similarity:430/644 - (66%) Gaps:29/644 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 GAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            |.|:|||||||.||:.|.:..:.::|.|.:|.|.|||:||||.:||||:|..||.|..:|..||.
  Rat    28 GTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV 92

  Fly   117 YATKRLIGRRFDDPEVKKDITNLSYKVVKASNG---DAWVSSTDGKVYSPSQIGAFILMKMKETA 178
            :..||||||.::||.|::||..|.:|||:....   ...:.....|.::|.:|.|.:|.||||||
  Rat    93 FDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETA 157

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-DKIIAV 242
            ||||...|.:|||||||||||:|||||||||.||||||:|:||||||||:|||:||.| :|.|.|
  Rat   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILV 222

  Fly   243 YDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQR 307
            :||||||||:|:|.|..|||||.:|||||.|||||||..::...:..:||.:|.|:||||.|:|:
  Rat   223 FDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQK 287

  Fly   308 LKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSD 372
            |:...||||..|||..|..|.:......    :..:..|||:|.|.|..||.:.|::|.||.|.|
  Rat   288 LRREVEKAKRALSSQHQARIEIESFFEG----EDFSETLTRAKFEELNMDLFRSTMKPVQKVLED 348

  Fly   373 AEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG--DVTD 434
            :::.||:|.|::||||.||:||:|..|:|.| |::|||.:|||||||.|||||.|||:|  |..|
  Rat   349 SDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGD 413

  Fly   435 VLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKL 499
            ::||||.||:|||||:|||.|:||.|||.:||||||:||||||.|..|.|||::|||.:..||.|
  Rat   414 LVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHL 478

  Fly   500 LGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENMIK 563
            ||:|.|.||||||||||||||.|:||.|||:.|:|:|||||.:.:|.| .....|:.:|||.|:.
  Rat   479 LGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVN 543

  Fly   564 KAEEYATADKQKRELIEIVNQGESIVHDTETKM---EEFKSQLPAEECEKLKKEIADLRTLLANK 625
            .||::|..||:.:|.|:..|:.||..:..:.::   |:...:|..|:.|.::|.:.:....|.:.
  Rat   544 DAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPEDKETMEKAVEEKIEWLESH 608

  Fly   626 ETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEE 684
            :.||:|:.:.....|::....:....|           |:|....:...|||   :|:|
  Rat   609 QDADIEDFKAKKKELEEIVQPIISKLY-----------GSGGPPPTGEEDTS---EKDE 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-5NP_001286414.1 dnaK 51..666 CDD:234715 312/624 (50%)
HSPA9-like_NBD 51..428 CDD:212683 204/380 (54%)
Syntaphilin <566..>642 CDD:291936 19/78 (24%)
Hspa5NP_037215.1 Required for interaction with KIAA1324. /evidence=ECO:0000250|UniProtKB:P11021 1..80 28/51 (55%)
HSPA5-like_NBD 28..403 CDD:212681 203/378 (54%)
HSP70 30..635 CDD:278441 309/608 (51%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 92/154 (60%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 4/9 (44%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 56/79 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 8/37 (22%)
Prevents secretion from ER 651..654 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D237853at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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