DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and ssa1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_593704.1	Gene:	ssa1 / 2542875	PomBaseID:	SPAC13G7.02c	Length:	644	Species:	Schizosaccharomyces pombe

Alignment Length:	602	Identity:	297/602 - (49%)
Similarity:	405/602 - (67%)	Gaps:	23/602 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119
            ||||||||.||:......:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||.:..
pombe     5 IGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPHNTIFDA 68

  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181
            ||||||||:||||:.|:.:..:||:: .:|...:.   ..:.|.::|.:|.:.:|:||:|:|||:
pombe    69 KRLIGRRFNDPEVQSDMKHWPFKVIE-KDGKPLIQVEFKGETKTFTPEEISSMVLLKMRESAEAF 132

  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIAVYD 244
            |...|.:|||||||||||||||||||||.||||||||:||||||||:|||:|::  .:..:.::|
pombe   133 LGGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQHETNVLIFD 197

  Fly   245 LGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLK 309
            |||||||:|:|.|::|:||||:|.|||.|||||||:.:||....|||:.:..||..:..|::||:
pombe   198 LGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFAQEFKRKNKKDITGNARAVRRLR 262

  Fly   310 EAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSD 372
            .|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|::|.:|.|.|
pombe   263 TACERAKRTLSSSAQASIEIDSLYEGID------FYTSITRARFEELCADLFRNTMEPVEKVLRD 321

  Fly   373 AEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGDVT--- 433
            :::.||.:.|::||||.||:|::|..|.:.| |::|.:|:|||||||.|||||..:|.||.:
pombe   322 SKIDKSSVNEIVLVGGSTRIPRIQKLVSDFFNGKEPCKSINPDEAVAYGAAVQAAILVGDTSEKT 386

  Fly   434 -DVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDN 497
             |:|||||.||||||||.|||.|.||.||||||||||:||||.:|.|..|.|:|.:|||....|.
pombe   387 QDLLLLDVAPLSLGIETAGGVMTPLIKRNTTIPTKKSEVFSTYADNQPGVLIQVFEGERARTKDC 451

  Fly   498 KLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEIENM 561
            .|||.|.|.||||||||||||||.||:|||||::|||.:|||||.|:|.| ...|.|||:||:.|
pombe   452 NLLGKFELSGIPPAPRGVPQIEVTFDVDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDRM 516

  Fly   562 IKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLRTLLAN 624
            :.:||:|...|:.:...|:..|..||..:.....:::  .|.::.|.:.|.:.|.:.:....|.:
pombe   517 VSEAEKYKAEDEAETSRIQAKNHLESYAYSLRNSLDDPNLKDKVDASDKEAIDKAVKETIEWLDH 581

  Fly   625 KETADLEEVRKATSSLQ 641
            ..||..:|.......|:
pombe   582 NTTAAKDEYEDKQKELE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	297/602 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	190/380 (50%)
		Syntaphilin	<566..>642	CDD:291936	16/78 (21%)
ssa1	NP_593704.1	PTZ00009	4..644	CDD:240227	297/602 (49%)
ssa1	NP_593704.1	HSPA1-2_6-8-like_NBD	4..378	CDD:212675	190/380 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810