DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and sks2

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_595438.1	Gene:	sks2 / 2540199	PomBaseID:	SPBC1709.05	Length:	613	Species:	Schizosaccharomyces pombe

Alignment Length:	616	Identity:	290/616 - (47%)
Similarity:	398/616 - (64%)	Gaps:	25/616 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSA 113
            ||....||||||||.||:||.|....::|.|.:|||||||.|||| :.|||||..||.||..|..
pombe     3 EVYEGAIGIDLGTTYSCVAVWETANVEIIPNDQGARTTPSFVAFT-ETERLVGDAAKNQAAMNPR 66

  Fly   114 NTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSST---DGKVYSPSQIGAFILMKMK 175
            ||.:..|||||||::|||.:|||.:..:||:. :||...:...   :.|.::..:|.|.:|.|||
pombe    67 NTVFDAKRLIGRRYEDPETQKDIKHWPFKVID-NNGIPTIEVNYLGEKKQFTAQEISAMVLTKMK 130

  Fly   176 ETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTED--K 238
            |.:||.||..|:.||:||||||:||||.||||||.||||||||:||||||||:|||:|...|  |
pombe   131 EISEAKLNKRVEKAVITVPAYFSDSQRAATKDAGAIAGLNVLRIINEPTAAAIAYGLDAKSDKPK 195

  Fly   239 IIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI 303
            .:.::||||||||:|:|:||.|||||.:|.|||.||||||||.:|...:.|||:...|||..|..
pombe   196 NVLIFDLGGGTFDVSLLKIQGGVFEVLATAGDTHLGGEDFDNALVEHFIQEFKRKQKIDISDDPR 260

  Fly   304 AMQRLKEAAEKAKCELSSSQQTDINLPYLT--MDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPC 366
            |::||:.|.|:||..|||..||.:.:..|:  :|      .:..:||::.|.:.....|.||.|.
pombe   261 ALRRLRSACERAKRALSSVTQTTVEVDSLSNGID------FSSSITRARFEDINATTFKATIDPV 319

  Fly   367 QKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLA- 429
            .|.|.|::|.|:::.:::||||.||:||||..|.:.| ||..::|:|||||||.|||||..||.
pombe   320 AKVLKDSKVPKADVHDIVLVGGSTRIPKVQRLVSDFFDGRALNKSINPDEAVAYGAAVQAAVLTN 384

  Fly   430 ---GDVT-DVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGE 490
               .|.| |:|||||.|||||:...|.||..:..|||.|||.|.:.|:|.:|.||.|...|:|||
pombe   385 KADSDKTQDLLLLDVVPLSLGVAMEGNVFGVVCPRNTPIPTIKKRTFTTVADNQTTVTFPVYQGE 449

  Fly   491 REMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQSS-GGLS 554
            |....:|:.||.|.|.||||.|||..::|..|::|||||:.|:|.:|.||:...|.|.:| |.||
pombe   450 RVNCAENEPLGEFQLTGIPPMPRGQAELEATFELDANGILKVTAVEKTTGRSAHIEITNSVGHLS 514

  Fly   555 KDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIAD 617
            ..:|:.||:.|:::...||...:.:|..:|.||.:.:.||.:.|  ...:|...:..|::.::|:
pombe   515 STKIQEMIENADKFKQQDKDFAKKLEAKSQLESYISNIETTISEPNVMMKLKRGDKSKIEAQLAE 579

  Fly   618 LRTLLANKETADLEEVRKATSSLQQSSLKLF 648
            ..:.|..::| :.:.:|||...|:::..|.|
pombe   580 CMSQLELEDT-NTDALRKAELRLKRTVQKAF 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	288/614 (47%)
		HSPA9-like_NBD	51..428	CDD:212683	198/384 (52%)
		Syntaphilin	<566..>642	CDD:291936	18/77 (23%)
sks2	NP_595438.1	HSP70	8..613	CDD:278441	288/611 (47%)
		HSPA1-2_6-8-like_NBD	8..383	CDD:212675	199/382 (52%)
		BAR	<503..>603	CDD:299863	28/100 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900