Protein Alignment Hsc70-5 and Hspa1l

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_997711.1
• Gene: Hspa1l / 24963
• RGDID: 1595925
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 596
• Identity: 303/596 - (50%)
• Similarity: 409/596 - (68%)
• Gaps: 21/596 - (3%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            ||..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
  Rat     5 KGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNT 68

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG--KVYSPSQIGAFILMKMKETA 178
            .:..||||||:|:||.|:.|:....::|:..:.....:.|..|  |.:.|.:|.:.:|.||||||
  Rat    69 VFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVLVSYKGEKKAFYPEEISSMVLTKMKETA 133

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE--DKIIA 241
            ||:|...|.|||:||||||||||||||||||.||||||||:||||||||:|||:||..  ::.:.
  Rat   134 EAFLGHSVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVL 198

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            ::||||||||:|||.|..|:||||:|.|||.||||||||.:|:..|.|||:....||.::..|::
  Rat   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263

  Fly   307 RLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369
            ||:.|.|:||..||||.|.::.:.  |..:|      ....:||::.|.|..||.:.|::|.:|:
  Rat   264 RLRTACERAKRTLSSSTQANLEIDSLYEGID------FYTSITRARFEELCADLFRGTLEPVEKS 322

  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD-- 431
            |.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
  Rat   323 LRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKS 387

  Fly   432 --VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494
              |.|:|||||.|||||:||.|||.|.||.||:|||||::|:|:|.||.|..|.|:|::|||.|.
  Rat   388 EKVQDLLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMT 452

  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558
            .||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:||
  Rat   453 RDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEI 517

  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKM--EEFKSQLPAEECEKLKKEIADLRTL 621
            |.|:::||.|...|:.:||.|...|..||...:.::.:  |..|.::...:.:|:..:.:::.:.
  Rat   518 ERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCSEVLSW 582

  Fly   622 LANKETADLEE 632
            |...:.|:.||
  Rat   583 LEANQLAEKEE 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	303/596 (51%)
Hspa1l	NP_997711.1	PTZ00009	3..641	CDD:240227	303/596 (51%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		200/389 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		74/114 (65%)