DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa1a

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_114177.2	Gene:	Hspa1a / 24472	RGDID:	1593284	Length:	641	Species:	Rattus norvegicus

Alignment Length:	662	Identity:	319/662 - (48%)
Similarity:	431/662 - (65%)	Gaps:	52/662 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            |...||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
  Rat     3 KKTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGD---AWVS-STDGKVYSPSQIGAFILMKMKE 176
            .:..||||||:|.||.|:.|:.:..::||  ::||   ..|: ..:.:.:.|.:|.:.:|.||||
  Rat    67 VFDAKRLIGRKFGDPVVQSDMKHWPFQVV--NDGDKPKVQVNYKGENRSFYPEEISSMVLTKMKE 129

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKI 239
            .|||||..||.|||:||||||||||||||||||.||||||||:||||||||:|||:|:|  .::.
  Rat   130 IAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN 194

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|..|:||||:|.|||.||||||||.:|:..|.|||:....||.::..|
  Rat   195 VLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRA 259

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..:.:..|  .:|      ....:||::.|.|..||.:.|::|.:
  Rat   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGID------FYTSITRARFEELCSDLFRGTLEPVE 318

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |||.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
  Rat   319 KALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGD 383

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.|||||:||.|||.|.||.||:|||||::|.|:|.||.|..|.|:|::|||.
  Rat   384 KSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERA 448

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:
  Rat   449 MTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKE 513

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTL 621
            |||.|:::||.|...|:.:||.:...|..||...:.::.:|:          |.||.:|::
  Rat   514 EIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVED----------EGLKGKISE---- 564

  Fly   622 LANKETADLEEVRKATSSLQQSSL-KLFELAYKKMSAERESN------------AGAGSSDSSSS 673
             |:|:.. |::.::..|.|..::| :..|..:|:...||..|            .|||...:.:.
  Rat   565 -ADKKKV-LDKCQEVISWLDSNTLAEKEEFVHKREELERVCNPIISGLYQGAGAPGAGGFGAQAP 627

  Fly   674 SDTSGEAKKEEK 685
            ...||.....|:
  Rat   628 KGGSGSGPTIEE 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	314/641 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	199/385 (52%)
		Syntaphilin	<566..>642	CDD:291936	18/75 (24%)
Hspa1a	NP_114177.2	PTZ00009	1..641	CDD:240227	319/662 (48%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		202/391 (52%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	198/383 (52%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		74/114 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920