Protein Alignment Hsc70-5 and Hspa8

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_077327.1
• Gene: Hspa8 / 24468
• RGDID: 621725
• Length: 646
• Species: Rattus norvegicus
• Alignment Length: 651
• Identity: 323/651 - (49%)
• Similarity: 430/651 - (66%)
• Gaps: 27/651 - (4%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            ||..:|||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
  Rat     3 KGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVK-ASNGDAWVS-STDGKVYSPSQIGAFILMKMKETA 178
            .:..||||||||||..|:.|:.:..:.||. |......|. ..:.|.:.|.::.:.:|.||||.|
  Rat    67 VFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIA 131

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIA 241
            ||||...|.||||||||||||||||||||||.||||||||:||||||||:|||:||.  .::.:.
  Rat   132 EAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVL 196

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            ::||||||||:|||.|:.|:||||||.|||.||||||||.:||..:||||:....||.::..|::
  Rat   197 IFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVR 261

  Fly   307 RLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369
            ||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|:.|.:||
  Rat   262 RLRTACERAKRTLSSSTQASIEIDSLYEGID------FYTSITRARFEELNADLFRGTLDPVEKA 320

  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD-- 431
            |.||::.||:|.:::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|:||
  Rat   321 LRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKS 385

  Fly   432 --VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494
              |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|..|.|:|::|||.|.
  Rat   386 ENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT 450

  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558
            .||.|||.|.|.||||||||||||||.||||||||::|||.||.||||.:|.| ...|.|||::|
  Rat   451 KDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDI 515

  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQ--LPAEECEKLKKEIADLRTL 621
            |.|:::||:|...|:::|:.:...|..||...:.:..:|:.|.|  :..|:.:|:..:..::.:.
  Rat   516 ERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISW 580

  Fly   622 LANKETADLEEVRKATSSLQQSS----LKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKK 682
            |...:||:.||.......|::..    .||::.|............|.|:..|..:|  ||...:
  Rat   581 LDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGAS--SGPTIE 643

  Fly   683 E 683
            |
  Rat   644 E 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	317/632 (50%)
Hspa8	NP_077327.1	PTZ00009	1..613	CDD:240227	315/616 (51%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..386		204/389 (52%)
		Interaction with BAG1. /evidence=ECO:0000250	186..377		95/196 (48%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..646		8/33 (24%)