DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa1a

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_034609.2	Gene:	Hspa1a / 193740	MGIID:	96244	Length:	641	Species:	Mus musculus

Alignment Length:	651	Identity:	313/651 - (48%)
Similarity:	425/651 - (65%)	Gaps:	30/651 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            |...||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Mouse     3 KNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVALNPQNT 66

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGD---AWVS-STDGKVYSPSQIGAFILMKMKE 176
            .:..||||||:|.|..|:.|:.:..::||  ::||   ..|: ..:.:.:.|.:|.:.:|.||||
Mouse    67 VFDAKRLIGRKFGDAVVQSDMKHWPFQVV--NDGDKPKVQVNYKGESRSFFPEEISSMVLTKMKE 129

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKI 239
            .|||||..||.|||:||||||||||||||||||.||||||||:||||||||:|||:|:|  .::.
Mouse   130 IAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERN 194

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|..|:||||:|.|||.||||||||.:|:..|.|||:....||.::..|
Mouse   195 VLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRA 259

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..:.:..|  .:|      ....:||::.|.|..||.:.|::|.:
Mouse   260 VRRLRTACERAKRTLSSSTQASLEIDSLFEGID------FYTSITRARFEELCSDLFRGTLEPVE 318

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |||.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
Mouse   319 KALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGD 383

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.|||||:||.|||.|.||.||:|||||::|.|:|.||.|..|.|:|::|||.
Mouse   384 KSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERA 448

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:
Mouse   449 MTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKE 513

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLR 619
            |||.|:::||.|...|:.:|:.:...|..||...:.::.:|:  .|.:|...:.:|:..:..::.
Mouse   514 EIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVI 578

  Fly   620 TLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEE 684
            :.|.:...||.||.......|::....:....|:...|     .|||...:.:....||.....|
Mouse   579 SWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGA-----PGAGGFGAQAPKGASGSGPTIE 638

  Fly   685 K 685
            :
Mouse   639 E 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	308/630 (49%)
		HSPA9-like_NBD	51..428	CDD:212683	198/385 (51%)
		Syntaphilin	<566..>642	CDD:291936	17/77 (22%)
Hspa1a	NP_034609.2	PTZ00009	1..641	CDD:240227	313/651 (48%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		201/391 (51%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	197/383 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		74/114 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820