Protein Alignment Hsc70-5 and hsp-6

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001370558.1
• Gene: hsp-6 / 178873
• WormBaseID: WBGene00002010
• Length: 657
• Species: Caenorhabditis elegans
• Alignment Length: 666
• Identity: 479/666 - (71%)
• Similarity: 568/666 - (85%)
• Gaps: 16/666 - (2%)

  Fly    20 SHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGAR 84
            |.:|.|.::.|     |:.:|:  |..|.:.||.||||||||||||:::||||..||||||||.|
 Worm     6 SFLSSARTIAR-----SSLMSA--RSLSDKPKGHVIGIDLGTTNSCVSIMEGKTPKVIENAEGVR 63

  Fly    85 TTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNG 149
            ||||.||||.|||||||.|||||||||||||.:|||||||||::||||:||:..:.||:||||||
 Worm    64 TTPSTVAFTADGERLVGAPAKRQAVTNSANTLFATKRLIGRRYEDPEVQKDLKVVPYKIVKASNG 128

  Fly   150 DAWVSSTDGKVYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGL 214
            ||||.: .||||||||:|||:|||||||||:||.|.|.||||||||||||||||||||||||:||
 Worm   129 DAWVEA-QGKVYSPSQVGAFVLMKMKETAESYLGTTVNNAVVTVPAYFNDSQRQATKDAGQISGL 192

  Fly   215 NVLRVINEPTAAALAYGMDK-TEDKIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDF 278
            |||||||||||||||||:|| ..|||||||||||||||:|||||||||||||||||||.||||||
 Worm   193 NVLRVINEPTAAALAYGLDKDAGDKIIAVYDLGGGTFDVSILEIQKGVFEVKSTNGDTFLGGEDF 257

  Fly   279 DNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMN 343
            |:.:|:.||.||||:.|:|:.||..|||||:||||||||||||:.||||||||:|||.:||:|:|
 Worm   258 DHALVHHLVGEFKKEQGVDLTKDPQAMQRLREAAEKAKCELSSTTQTDINLPYITMDQSGPKHLN 322

  Fly   344 LKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPS 408
            |||||:|.|.:|||||||||:||:|||.||||..|:|.:|||||||:||||||:||||:||:.||
 Worm   323 LKLTRAKFEQIVGDLIKRTIEPCRKALHDAEVKSSQIADVLLVGGMSRMPKVQATVQEIFGKVPS 387

  Fly   409 RSVNPDEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFS 473
            ::||||||||:|||:||.||||||||||||||||||||||||||:.|:||:||||||||||||||
 Worm   388 KAVNPDEAVAMGAAIQGAVLAGDVTDVLLLDVTPLSLGIETLGGIMTKLITRNTTIPTKKSQVFS 452

  Fly   474 TASDGQTQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKG 538
            ||:||||||:|||.|||||||..|||||.|:|||||||||||||:||.|||||||||:|||:|:|
 Worm   453 TAADGQTQVQIKVFQGEREMATSNKLLGQFSLVGIPPAPRGVPQVEVTFDIDANGIVNVSARDRG 517

  Fly   539 TGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQL 603
            ||||||||||||||||||:||||||:||:.|..|.:::||:|::||.|.|:||||.||.||..||
 Worm   518 TGKEQQIVIQSSGGLSKDQIENMIKEAEKNAAEDAKRKELVEVINQAEGIIHDTEAKMTEFADQL 582

  Fly   604 PAEECEKLKKEIADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSS 668
            |.:|||.|:.:|||.:.:|.||:....|.:::|.::|||.||||||.|||.|:|:   |:|..:.
 Worm   583 PKDECEALRTKIADTKKILDNKDNETPEAIKEACNTLQQQSLKLFEAAYKNMAAK---NSGGDAQ 644

  Fly   669 DSSSSSDTSGEAKKEE 684
            ::.    |:.|.|||:
 Worm   645 EAK----TAEEPKKEQ 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	466/615 (76%)
		HSPA9-like_NBD	51..428	CDD:212683	296/377 (79%)
		Syntaphilin	<566..>642	CDD:291936	34/75 (45%)
hsp-6	NP_001370558.1	dnaK	30..646	CDD:234715	466/619 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162755
Domainoid	1	1.000	900	1.000	Domainoid score	I12
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39452
Inparanoid	1	1.050	934	1.000	Inparanoid score	I173
Isobase	1	0.950	-	0	Normalized mean entropy	S115
OMA	1	1.010	-	-		QHG61239
OrthoDB	1	1.010	-	-		D237853at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		oto17532
orthoMCL	1	0.900	-	-		OOG6_100423
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R575
SonicParanoid	1	1.000	-	-		X1906
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750