DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and hsp-1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_503068.1	Gene:	hsp-1 / 178507	WormBaseID:	WBGene00002005	Length:	640	Species:	Caenorhabditis elegans

Alignment Length:	651	Identity:	324/651 - (49%)
Similarity:	435/651 - (66%)	Gaps:	33/651 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KGAVIGIDLGTTNSCLAV-MEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSAN 114
            |...:|||||||.||:.| |.|| .::|.|.:|.|||||:|||| |.|||:|..||.|...|..|
Worm     3 KHNAVGIDLGTTYSCVGVFMHGK-VEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPHN 65

  Fly   115 TFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKE 176
            |.:..||||||:||||.|:.|:.:..:||:.|......|.   ..:.|:::|.:|.:.:|:||||
Worm    66 TVFDAKRLIGRKFDDPAVQSDMKHWPFKVISAEGAKPKVQVEYKGENKIFTPEEISSMVLLKMKE 130

  Fly   177 TAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKI 239
            ||||:|.|.||:|||||||||||||||||||||.||||||||:||||||||:|||:||.  .::.
Worm   131 TAEAFLGTTVKDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKKGHGERN 195

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            :.::||||||||:|||.|:.|:||||||.|||.||||||||.:||...||||:....|:..:..|
Worm   196 VLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFCAEFKRKHKKDLASNPRA 260

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYL--TMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            ::||:.|.|:||..||||.|..|.:..|  .:|      ....:||::.|.|..||.:.|:.|.:
Worm   261 LRRLRTACERAKRTLSSSSQASIEIDSLFEGID------FYTNITRARFEELCADLFRSTMDPVE 319

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD 431
            |:|.||::.||::.:::||||.||:||||..:.:|| |::.::|:|||||||.|||||..:|:||
Worm   320 KSLRDAKMDKSQVHDIVLVGGSTRIPKVQKLLSDLFSGKELNKSINPDEAVAYGAAVQAAILSGD 384

  Fly   432 ----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGERE 492
                |.|:|||||.||||||||.|||.|.||.||||||||.:|.|:|.||.|..|.|:|::|||.
Worm   385 KSEAVQDLLLLDVAPLSLGIETAGGVMTALIKRNTTIPTKTAQTFTTYSDNQPGVLIQVYEGERA 449

  Fly   493 MANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKD 556
            |..||.|||.|.|.||||||||||||||.||||||||::|||.||.|||:.:|.| ...|.||||
Worm   450 MTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSATDKSTGKQNKITITNDKGRLSKD 514

  Fly   557 EIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEE--FKSQLPAEECEKLKKEIADLR 619
            :||.|:.:||:|...|:.:::.|...|..||...:.:..:|:  .|.::..|:.:|::.:..::.
Worm   515 DIERMVNEAEKYKADDEAQKDRIGAKNGLESYAFNLKQTIEDEKLKDKISPEDKKKIEDKCDEIL 579

  Fly   620 TLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGA--GSSDSSSSSDTSGEAKK 682
            ..|.:.:||:.||...     ||..|:  .||...:|...:|..||  |::...::....|...:
Worm   580 KWLDSNQTAEKEEFEH-----QQKDLE--GLANPIISKLYQSAGGAPPGAAPGGAAGGAGGPTIE 637

  Fly   683 E 683
            |
Worm   638 E 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	321/632 (51%)
		HSPA9-like_NBD	51..428	CDD:212683	203/385 (53%)
		Syntaphilin	<566..>642	CDD:291936	16/77 (21%)
hsp-1	NP_503068.1	PTZ00009	1..614	CDD:240227	318/625 (51%)
hsp-1	NP_503068.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	202/383 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820