DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and stc-1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_495808.2	Gene:	stc-1 / 174368	WormBaseID:	WBGene00006059	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	139/388 - (35%)
Similarity:	217/388 - (55%)	Gaps:	20/388 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VIGIDLGTTNSCLAVMEGKQAK--VIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            :.|||||||.|.:.:......:  ::.:..|.::.||.|||..:|..|:|..|..|...|...|.
Worm    35 IAGIDLGTTYSSIGIYHAVTGETIILPDDLGKKSVPSVVAFLPNGTVLIGTRATEQQEHNPKRTI 99

  Fly   117 YATKRLIGRRFD--DPEVKKDITNLSYKVVKASNGDAW----VSSTDGKVYSPSQIGAFILMKMK 175
            |..||.|||.|:  :.:...|.....:|:...|.|.|:    :.|....|| |.:||:.|:..:|
Worm   100 YDAKRFIGRNFEKNNKDFLSDQKRYPFKINLDSEGKAFFEIPLDSGTKNVY-PEEIGSLIIGYLK 163

  Fly   176 ETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTED-KI 239
            ..|..:|...:...|::.||.||:.||..|..|.:||.:.|.|||:||||||||||:.|.:. :.
Worm   164 SAAAKHLGVTLGQVVISCPAEFNEKQRNFTAKAAEIAEMEVRRVISEPTAAALAYGLHKKQGVEN 228

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSG--IDIRKDN 302
            :.|.||||||.|:|:|.:|.|||..::..|:..|||:||::.:...|:::..:..|  ||.::|
Worm   229 VVVVDLGGGTLDVSVLWLQGGVFVTQAMAGNNRLGGQDFNDRVQKHLISKIAEKFGKTIDNKED- 292

  Fly   303 IAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
              :|:::...||.|..|::...|.|:|...|:.     ..|.:|||.:.|:|.|||:|....|..
Worm   293 --IQQIRMEVEKGKIRLTNVPSTTISLNLKTVG-----KWNYELTRDEFETLNGDLLKAIELPIT 350

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVLAG 430
            .||:||.:..:::.|::||||.|::|.|:..|...|.:..:..|:|:.||..||:||.||:.|
Worm   351 AALADANLDTADVDEIVLVGGSTQVPAVRKIVGRFFKKSANYGVDPELAVVTGASVQAGVIGG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	139/388 (36%)
		HSPA9-like_NBD	51..428	CDD:212683	137/384 (36%)
		Syntaphilin	<566..>642	CDD:291936
stc-1	NP_495808.2	HSPA13-like_NBD	13..427	CDD:212679	139/388 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910