DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and T24H7.2

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_495249.1	Gene:	T24H7.2 / 174033	WormBaseID:	WBGene00020781	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	171/711 - (24%)
Similarity:	302/711 - (42%)	Gaps:	139/711 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVME-GKQAKVIENAEGARTTPSHVAFTKDGER-----LVGMPAKRQAVTN 111
            |.:.|||||....:.::: |....:..|.|..|.|| :|...:||.|     .:||..:...:.:
Worm    25 AAMTIDLGTQFLKIGIVKPGIPMDIALNTESRRKTP-NVVMIQDGHRTFADAAIGMQVRYPHLVH 88

  Fly   112 -------SANTFYATKRLIGRR---FDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKVYSPSQI 166
                   ..:|.:.:..|..||   |:..:..|:.:::::|:             .|:.|:...:
Worm    89 GQLNDLVGKSTQHPSFELFKRRNTFFEVDDAPKNASSINFKL-------------GGESYTVEAL 140

  Fly   167 GAFILMKMKETAEAYLN-TPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAY 230
            .|.||...|:..|.|.. ..:|:.|:|||.||..::|.|.:.|.|:|||.||::||:.|||||::
Worm   141 TAMILANAKKFTEEYAQAAEIKDVVITVPVYFTPAERLAVERAAQMAGLTVLQLINDGTAAALSH 205

  Fly   231 GMDKTED-----KIIAVYDLGGGTFDISILEIQ--KGVFE------VKSTNGDTLLGGEDFDNHI 282
            |:.:.::     :.:.|||:|......:|:|.:  |..:|      |.....|..|||.:..|.:
Worm   206 GIFRRKEIGEKPQRLMVYDMGAAKTTATIVEFKLVKEKYEKQPKMTVLGVGFDRTLGGIEMTNRL 270

  Fly   283 VNFLVAEFKKD--SGIDIRKDNIAMQRLKEAAEKAKCELSSSQQ--TDINLPYLTMDAAGPQHMN 343
            .:.|:..|:|:  ....:..:..||.:..:.||:.|..||::.:  ..|...:..:||      .
Worm   271 RDHLIEMFEKNYKPKTKVNTNRRAMTKFSKEAERLKQVLSANAEHFAQIESAHEDIDA------K 329

  Fly   344 LKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFG-RQP 407
            ||:||.....|:.|:..|..:|.::||..|::...:|.:.:|:|..||:||||..||:..| ::.
Worm   330 LKVTREDFNHLISDMESRFGEPIEQALRMAQIPIDDIDQFVLMGAGTRVPKVQEIVQKTIGTKEI 394

  Fly   408 SRSVNPDEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLISR------------ 460
            .:.:|.|||||:||..|...|:..      ..|.|.::..:.:..|....:|:
Worm   395 GKFLNTDEAVAMGALFQAAHLSKG------FKVKPFNIEEKVIFPVEVHFVSKIRDEKTEEITGE 453

  Fly   461 ----------NTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKLLGSF-------TLVGI 508
                      |:..||....:..|:......|.:|..:.|.......:.:||.       .:.|:
Worm   454 KNVVKTLFAANSVYPTHPKTISLTSYSDDFSVALKYGKIESFTKQQVQEIGSLLDNLVDVEISGL 518

  Fly   509 PPAPRG-------VPQIEVVFDIDANGIVHV----SAKDKGTGKEQQIVIQSSGGLSKDEIENMI 562
            ..|.:.       ...::|.|.:||:|||.|    :..:..:|....|....||..|....|.
Worm   519 SEALKNRSSEESEFKGVKVSFIVDASGIVRVRRAEALFEPKSGLVGSIASTISGLFSSKTEEG-- 581

  Fly   563 KKAEEYATADKQKRELIEIVNQGESI-VHDT------ETKMEEFKSQLP-------------AEE 607
                |..|.|...:...|...:.||: |.|:      ||.:.....:.|             |.|
Worm   582 ----EPTTDDSTPQSTEEKTEEKESVKVEDSTPEPEPETPVNSTSEESPKTNETEKNASSGNATE 642

  Fly   608 CEKLKKEIADL-RTLLANKETA-------DLEEVRKATSSLQQSSLKLFELAYKKMSAERE 660
            .::.|||:..: |..:.||..:       |::|.::...:..:..    .||.::.:.|.|
Worm   643 VKEKKKELPSIVRLRITNKYPSAFVPNKYDVQEEKRRMEAFAEKE----RLASERAAVENE 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	171/711 (24%)
		HSPA9-like_NBD	51..428	CDD:212683	116/409 (28%)
		Syntaphilin	<566..>642	CDD:291936	21/103 (20%)
T24H7.2	NP_495249.1	HYOU1-like_NBD	27..413	CDD:212672	115/405 (28%)
T24H7.2	NP_495249.1	DnaK	29..669	CDD:223520	164/671 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900