Protein Alignment Hsc70-5 and hsp-70

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_492485.1
• Gene: hsp-70 / 172757
• WormBaseID: WBGene00002026
• Length: 643
• Species: Caenorhabditis elegans
• Alignment Length: 649
• Identity: 309/649 - (47%)
• Similarity: 421/649 - (64%)
• Gaps: 34/649 - (5%)

  Fly    55 IGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYAT 119
            ||||||||.||:.:.:..:.:::.|:||.:||||:|||| |.|||||..||.||..|..||.:..
 Worm     7 IGIDLGTTYSCVGIYQNGKVEILANSEGNKTTPSYVAFT-DTERLVGDAAKDQAARNPENTVFDA 70

  Fly   120 KRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAY 181
            |||||||||:..|:.||.:..: .||...|...|.   ..:.:.::..:|.|.:|.||||||||.
 Worm    71 KRLIGRRFDEETVQSDIKHWPF-TVKGKQGKPVVEVEVKGEKREFNAEEISAMVLQKMKETAEAV 134

  Fly   182 LNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK--TEDKIIAVYD 244
            |...|::||:|||||||||||||||||..|||||.:|:||||||||||||:||  |::|.|.::|
 Worm   135 LGHSVRDAVITVPAYFNDSQRQATKDAATIAGLNAIRIINEPTAAALAYGLDKGITDEKNILIFD 199

  Fly   245 LGGGTFDISILEIQKG-VFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRL 308
            |||||||:|||.|.:| :||||||.|||.|||||||:.::...:.|||:.:|.||..:..|::||
 Worm   200 LGGGTFDVSILSIAEGSIFEVKSTAGDTHLGGEDFDSRVLQHFMTEFKRKTGKDISSNPRAIRRL 264

  Fly   309 KEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDA 373
            :.|.|:||..||||.:..:.:..| .|..   ....|:||::.|.|..||.::|::|.:|||.||
 Worm   265 RTACERAKRTLSSSTEATVEVDSL-FDGT---DFYSKITRARFEELCADLFRKTLEPVEKALRDA 325

  Fly   374 EVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG----DVT 433
            :..|..|.||:||||.||:||:|..::|.| |:..:.|:|||||||.|||||..||:|    .:.
 Worm   326 KTDKGRIDEVVLVGGSTRIPKIQKLLKEFFNGKDLNCSINPDEAVAFGAAVQAAVLSGVKDDTIK 390

  Fly   434 DVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNK 498
            ||||:||.|||.||||.|||.|.||.|||.||.|.|:.|:|.:|.|..|.|:|::|||.|..||.
 Worm   391 DVLLVDVVPLSHGIETAGGVMTNLIDRNTRIPAKASKTFTTYADNQPGVSIQVYEGERAMTRDNH 455

  Fly   499 LLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQS-SGGLSKDEIENMI 562
            .||:|.|.|||||||||||::|.||||||||::|||.||.||:..:|.|:: .|.||:.:|:.|:
 Worm   456 RLGTFELTGIPPAPRGVPQVDVTFDIDANGILNVSAADKSTGRSNRITIRNEKGRLSQADIDRMV 520

  Fly   563 KKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADL-----RTLL 622
            .:|:::...|..:|:.|...||.|:.....:..:||..|.|.||:.::.|..:.|.     |..|
 Worm   521 NEAKQFEREDAAQRDRISSRNQLEAYAFQVKQALEEHGSLLSAEDAKRAKDAVEDTLRWMERNTL 585

  Fly   623 ANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSS---SSSDTSGEAKKE 683
            |:|:  ::|...|...|:.|      ::..|....|.:|.:|.|:..|.   ||:...|...:|
 Worm   586 ADKD--EIEAKDKELKSICQ------DILTKMHQQEAQSGSGCGNPGSGGFHSSNYPQGPTVEE 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	303/627 (48%)
		HSPA9-like_NBD	51..428	CDD:212683	196/379 (52%)
		Syntaphilin	<566..>642	CDD:291936	21/80 (26%)
hsp-70	NP_492485.1	PTZ00009	1..643	CDD:240227	309/649 (48%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	197/380 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820