Protein Alignment Hsc70-5 and Hspa9

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_034611.2
• Gene: Hspa9 / 15526
• MGIID: 96245
• Length: 679
• Species: Mus musculus
• Alignment Length: 681
• Identity: 511/681 - (75%)
• Similarity: 587/681 - (86%)
• Gaps: 19/681 - (2%)

  Fly    12 ARQAGVVPSHMSGASSMFRNLPGASNGIS-------SQLRYKSGEVKGAVIGIDLGTTNSCLAVM 69
            ||..|...|....|:   |...| .||:|       |:..|.|..:||||:||||||||||:|||
Mouse    10 ARLVGTAASRSPAAA---RPQDG-WNGLSHEAFRFVSRRDYASEAIKGAVVGIDLGTTNSCVAVM 70

  Fly    70 EGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKK 134
            |||||||:|||||||||||.||||.|||||||||||||||||..|||||||||||||:|||||:|
Mouse    71 EGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQK 135

  Fly   135 DITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFND 199
            |..|:.:|:|:||||||||.: .||:|||||||||:|||||||||.||....||||:||||||||
Mouse   136 DTKNVPFKIVRASNGDAWVEA-HGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFND 199

  Fly   200 SQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDKIIAVYDLGGGTFDISILEIQKGVFEV 264
            ||||||||||||:|||||||||||||||||||:||:|||:|||||||||||||||||||||||||
Mouse   200 SQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEV 264

  Fly   265 KSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINL 329
            |||||||.|||||||..::..:|.|||:::|:|:.|||:|:||::|||||||||||||.||||||
Mouse   265 KSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINL 329

  Fly   330 PYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPK 394
            |||||||:||:|:|:||||::.|.:|.|||||||.|||||:.|||||||:||||:||||||||||
Mouse   330 PYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPK 394

  Fly   395 VQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTRLIS 459
            ||.|||:||||.||::||||||||:|||:||||||||||||||||||||||||||||||||:||:
Mouse   395 VQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLIN 459

  Fly   460 RNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDI 524
            ||||||||||||||||:||||||||||.|||||||.||||||.|||:||||||||||||||.|||
Mouse   460 RNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDI 524

  Fly   525 DANGIVHVSAKDKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIV 589
            ||||||||||||||||:|||||||||||||||:||||:|.||:||..|::|:|.:|.||..|.|:
Mouse   525 DANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGII 589

  Fly   590 HDTETKMEEFKSQLPAEECEKLKKEIADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKK 654
            |||||||||||.||||:||.|||:||:.:|.|||.|::...|.:|:|.|||||:||||||:||||
Mouse   590 HDTETKMEEFKDQLPADECNKLKEEISKMRALLAGKDSETGENIRQAASSLQQASLKLFEMAYKK 654

  Fly   655 MSAERESNAGAGSSDSSSSSDTSGEAKKEEK 685
            |::|||   |:|||.:....    |.:||||
Mouse   655 MASERE---GSGSSGTGEQK----EDQKEEK 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	490/614 (80%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		319/426 (75%)
		dnaK	52..673	CDD:234715	493/628 (79%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646	63..431		295/368 (80%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		191/254 (75%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646	432..441		8/8 (100%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646	442..679		181/244 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		12/30 (40%)