DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa4

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	653	Identity:	190/653 - (29%)
Similarity:	304/653 - (46%)	Gaps:	106/653 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFY 117
            :|:|||||..:..:||......:.|.|....|.||:.|:|... .|.:|..||.|.::|:.||..
Mouse     2 SVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPK-NRSIGAAAKSQVISNAKNTVQ 65

  Fly   118 ATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSST---DGKVYSPSQIGAFILMKMKETAE 179
            ..||..||.|.||.|:.:.:||:|.:|:...|...:..|   :.:.::..|:.|.:|.|:|||||
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   180 AYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-------D 237
            :.|..||.:.||:||:::.|::|::..||.||||||.||::||.||.|||||:.|.:       .
Mouse   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   238 KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDN 302
            :.:...|:|...:.:|:....||..:|.:|..||.|||..||..:||....||.|...:||:...
Mouse   196 RNVVFVDMGHSAYQVSVCAFNKGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260

  Fly   303 IAMQRLKEAAEKAKCELSSSQQTDINLP---YLT-MDAAGPQHMNLKLTRSKLESLVGDLIKRTI 363
            .|:.||.:..||.| :|.|:..:|:.|.   ::. :|.:|      .:.|.|...:..||:.|..
Mouse   261 RALLRLSQECEKLK-KLMSANASDLPLSIECFMNDIDVSG------TMNRGKFLEMCDDLLARVE 318

  Fly   364 QPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL 428
            .|.:..|..:::.|.:|..|.:|||.||:|.|:..:.:.||::.|.::|.||||..|.|:|..:|
Mouse   319 PPLRSVLEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAIL 383

  Fly   429 --AGDVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEI--KVHQG 489
              |..|.:..:.||.|..:.:                      :..|.|.:|.:..|:  |.|
Mouse   384 SPAFKVREFSITDVVPYPISL----------------------RWNSPAEEGLSDCEVFPKNH-- 424

  Fly   490 EREMANDNKLL-----GSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQS 549
               .|..:|:|     ..|||.....:|:.:|..:       ..|...|.        |::..||
Mouse   425 ---AAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPD-------PAIAQFSV--------QKVTPQS 471

  Fly   550 SGGLSKDEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKE 614
            .|..||.:::   .:...:.........|:|        ||.:|...|..::...|:|.||::
Mouse   472 DGSSSKVKVK---VRVNVHGIFSVSSAALVE--------VHKSEESEEPMETDQNAKEEEKMQ-- 523

  Fly   615 IADLRTLLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGE 679
                    .::|....||.:      ||....    |..|..:|....:.|||.|  ..:|...:
Mouse   524 --------VDQEEPHTEEQQ------QQPQTP----AENKAESEEMETSQAGSKD--KKTDQPPQ 568

  Fly   680 AKK 682
            |||
Mouse   569 AKK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	182/635 (29%)
		HSPA9-like_NBD	51..428	CDD:212683	136/388 (35%)
		Syntaphilin	<566..>642	CDD:291936	13/75 (17%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	136/389 (35%)
		HSP70	3..609	CDD:278441	190/652 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		24/94 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900