Protein Alignment Hsc70-5 and Hspa2

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_032327.2
• Gene: Hspa2 / 15512
• MGIID: 96243
• Length: 633
• Species: Mus musculus
• Alignment Length: 645
• Identity: 312/645 - (48%)
• Similarity: 423/645 - (65%)
• Gaps: 51/645 - (7%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            :|..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Mouse     4 RGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 67

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKET 177
            .:..||||||:|:|..|:.|:.:..::|| :..|...|.   ..:.|.:.|.:|.:.:|.||||.
Mouse    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVV-SEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEI 131

  Fly   178 AEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT----EDK 238
            |||||...|::||:||||||||||||||||||.|.||||||:||||||||:|||:||.    .:|
Mouse   132 AEAYLGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEK 196

  Fly   239 IIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI 303
            .:.::||||||||:|||.|:.|:||||||.|||.||||||||.:|:.|..|||:....||..:..
Mouse   197 NVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKR 261

  Fly   304 AMQRLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPC 366
            |::||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|::|.
Mouse   262 AVRRLRTACERAKRTLSSSTQASIEIDSLYEGVD------FYTSITRARFEELNADLFRGTLEPV 320

  Fly   367 QKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG 430
            :|||.||::.|.:|.|::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|.|
Mouse   321 EKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIG 385

  Fly   431 D----VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGER 491
            |    |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|:.|.::|::|||
Mouse   386 DKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER 450

  Fly   492 EMANDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSK 555
            .|..||.|||.|.|.||||||||||||||.||||||||::|:|.||.||||.:|.| ...|.|||
Mouse   451 AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSK 515

  Fly   556 DEIENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRT 620
            |:|:.|:::||.|.:.|:..|:.:...|..||..::.:..:|:          |||:.:|::
Mouse   516 DDIDRMVQEAERYKSEDEANRDRVAAKNAVESYTYNIKQTVED----------EKLRGKISE--- 567

  Fly   621 LLANKETADLEEVRKATSSLQQSSL-KLFELAYKKMSAERESN-----------AGAGSS 668
               ..:...|::.::..:.|.::.: :..|..:|:...||..|           .|.|||
Mouse   568 ---QDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSS 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	309/641 (48%)
Hspa2	NP_032327.2	PTZ00009	2..615	CDD:240227	308/634 (49%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		200/392 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		77/114 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..633		4/12 (33%)