Protein Alignment Hsc70-5 and Hsph1

DIOPT Version :9

• Sequence 1: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_006504979.1
• Gene: Hsph1 / 15505
• MGIID: 105053
• Length: 877
• Species: Mus musculus
• Alignment Length: 768
• Identity: 202/768 - (26%)
• Similarity: 324/768 - (42%)
• Gaps: 188/768 - (24%)

  Fly    74 AKVIENAEGART--TPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGRRFDDPEVKKDI 136
            :|..|...|:.|  ..|.::|... .|.:|:.||.|.:|::.||..:.||..||.|:||.::|:.
Mouse    40 SKAREEGSGSGTWRRRSVISFGSK-NRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEK 103

  Fly   137 TNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEAYLNTPVKNAVVTVPAYFN 198
            .||||.:|...||...:.   ..:...:|..||.|.:|.|:|||||..|..||.:.|::||::|.
Mouse   104 ENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFT 168

  Fly   199 DSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDK-----TEDK--IIAVYDLGGGTFDISILE 256
            |::|::..||.||.|||.||::|:.||.||.||:.|     .|:|  ::...|:|..:|.:|...
Mouse   169 DAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACA 233

  Fly   257 IQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSS 321
            ..||..:|..|..|..|||::||..:|....||||....:|.:....|:.||.:..||.| :|.|
Mouse   234 FNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLK-KLMS 297

  Fly   322 SQQTD--INLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVL 384
            |..||  :|:.....|    :.::.|:.||:.|.|..:|:::...|....::..::...::..:.
Mouse   298 SNSTDLPLNIECFMND----KDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIE 358

  Fly   385 LVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL--AGDVTDVLLLDVTPLSLGI 447
            :|||.||:|.|:..:.:.||:..|.::|.|||||.|.|:|..:|  |..|.:..:.|..|..:.:
Mouse   359 IVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISL 423

  Fly   448 ------ETLGGVFTRLISRNTTIPTKKSQVF---------------------------------S 473
                  |...||. .:.|||...|..|...|                                 |
Mouse   424 VWNHDSEETEGVH-EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVS 487

  Fly   474 TASDGQ-TQVEIKVHQGEREMANDNKLLGSFTL------VGIPPAPRGVPQIEVVF--------- 522
            ...||: ::|::||.....         |.||:      ..:|........:|...
Mouse   488 AQKDGEKSRVKVKVRVNTH---------GIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTE 543

  Fly   523 --DIDANGIVHVSAKDKGTGKEQQIVIQSSGGLSKDEIENMIKKAEEYATAD------------- 572
              |:|.|  :.....:.||    |..:|:.|..:.....:....:||..|.|
Mouse   544 SSDVDKN--IQQDNSEAGT----QPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPP 602

  Fly   573 KQKRELIEIVN------------------------QGESIVHD------------TETKMEEFKS 601
            :.|:..|::||                        :|:.|:.|            .|..:.||:.
Mouse   603 EAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRD 667

  Fly   602 QL--PAEE--CEKLKKEIADLRTLLANKETAD-----------------LEEVRKATSSL----- 640
            :|  |.|:  ||:..::...|.|     ||.|                 |||:.|..:.:
Mouse   668 KLCGPYEKFICEQEHEKFLRLLT-----ETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQ 727

  Fly   641 --QQSSLKLFELA-----YKKMSAERESNAGAGSSDSSSSSDTSGEAKKEEKN 686
              ::....|.||.     |.|::|:..     |..:..:..|.| |.||.||:
Mouse   728 EAEERPKVLEELGQRLQHYAKIAADFR-----GKDEKYNHIDES-EMKKVEKS 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	194/746 (26%)
		HSPA9-like_NBD	51..428	CDD:212683	127/367 (35%)
		Syntaphilin	<566..>642	CDD:291936	28/152 (18%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	123/352 (35%)
		FtsN	<537..>620	CDD:225629	16/88 (18%)
		DUF4127	<673..761	CDD:379257	19/97 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900