Protein Alignment Hsc70-5 and Hspa1l

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Alignment Length: 611
• Identity: 310/611 - (50%)
• Similarity: 412/611 - (67%)
• Gaps: 32/611 - (5%)

  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            ||..||||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
Mouse     5 KGMAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPQNT 68

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDG--KVYSPSQIGAFILMKMKETA 178
            .:..||||||:|:||.|:.|:....::|:..:.....:.|..|  |.:.|.:|.:.:|.||||||
Mouse    69 VFDAKRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETA 133

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE--DKIIA 241
            ||:|...|.|||:||||||||||||||||||.||||||||:||||||||:|||:||..  ::.:.
Mouse   134 EAFLGHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVL 198

  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306
            ::||||||||:|||.|..|:||||:|.|||.||||||||.:|:..|.|||:....||.::..|::
Mouse   199 IFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVR 263

  Fly   307 RLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369
            ||:.|.|:||..||||.|.::.:.  |..:|      ....:||::.|.|..||.:.|::|.:|:
Mouse   264 RLRTACERAKRTLSSSTQANLEIDSLYEGID------FYTSITRARFEELCADLFRGTLEPVEKS 322

  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD-- 431
            |.||::.|::|.:::||||.||:||||..:|:.| ||..::|:|||||||.|||||..:|.||
Mouse   323 LRDAKMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKS 387

  Fly   432 --VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494
              |.|:|||||.|||||:||.|||.|.||.||:|||||::|:|:|.||.|..|.|:|::|||.|.
Mouse   388 EKVQDLLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMT 452

  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558
            .||.|||.|.|.||||||||||||||.||||||||::|:|.||.|||..:|.| ...|.|||:||
Mouse   453 RDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEI 517

  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKM--EEFKSQLPAEECEKLKKEIAD---- 617
            |.|:::||.|...|:.:||.|...|..||...:.::.:  |..|.::    .|..||:|.|
Mouse   518 ERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKI----SESDKKKILDKCNE 578

  Fly   618 -LRTLLANK--ETADLEEVRKATSSL 640
             |..|.||:  |..:.:..||...::
Mouse   579 VLSWLEANQLAEKDEFDHKRKELENM 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	310/611 (51%)
Hspa1l	NP_038586.2	PTZ00009	3..641	CDD:240227	310/611 (51%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		200/389 (51%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		74/114 (65%)