DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70-5 and AgaP_AGAP010876

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_309825.4	Gene:	AgaP_AGAP010876 / 1271080	VectorBaseID:	AGAP010876	Length:	641	Species:	Anopheles gambiae

Alignment Length:	642	Identity:	561/642 - (87%)
Similarity:	606/642 - (94%)	Gaps:	1/642 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YKSGEVKGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAV 109
            |:|.:||||||||||||||||:||||||.||||||||||||||||||||||||||||||||||||
Mosquito     1 YRSEQVKGAVIGIDLGTTNSCVAVMEGKNAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAV 65

  Fly   110 TNSANTFYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAFILMKM 174
            ||||||||||||||||||||.|:|||:.||||||||||||||||..:|||||||||||||:||||
Mosquito    66 TNSANTFYATKRLIGRRFDDAEIKKDLANLSYKVVKASNGDAWVQGSDGKVYSPSQIGAFVLMKM 130

  Fly   175 KETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDKI 239
            :|||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||:||||
Mosquito   131 RETAEAYLNTPVKNAVITVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKSEDKI 195

  Fly   240 IAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIA 304
            ||||||||||||||:||||||||||||||||||||||||||||:|:|.||||||.||||:||.:|
Mosquito   196 IAVYDLGGGTFDISVLEIQKGVFEVKSTNGDTLLGGEDFDNHILNYLAAEFKKDQGIDIKKDAMA 260

  Fly   305 MQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369
            ||||||||||||||||||.|||||||||||||:||:|:||||||:|||:||||||||||.|||||
Mosquito   261 MQRLKEAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNLKLTRAKLETLVGDLIKRTIAPCQKA 325

  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVLAGDVTD 434
            :||||||||:||||||||||||||||||.|||:|||||||:||||||||||||||||||||||||
Mosquito   326 MSDAEVSKSDIGEVLLVGGMTRMPKVQSLVQEVFGRQPSRAVNPDEAVAVGAAVQGGVLAGDVTD 390

  Fly   435 VLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMANDNKL 499
            ||||||||||||||||||||||||:||||||||||||||||:||||||||||||||||||:|||:
Mosquito   391 VLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADGQTQVEIKVHQGEREMASDNKM 455

  Fly   500 LGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVIQSSGGLSKDEIENMIKK 564
            |||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||.
Mosquito   456 LGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSARDKGTGKEQQIVIQSSGGLSKDEIENMIKN 520

  Fly   565 AEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAEECEKLKKEIADLRTLLANKETAD 629
            ||:||.|||||::.||.|||.|.|||||||||||||.|||.|||:||::|||.:|.:|||||.||
Mosquito   521 AEQYAQADKQKKDRIEAVNQAEGIVHDTETKMEEFKDQLPKEECDKLREEIAKVREILANKEEAD 585

  Fly   630 LEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEEKN 686
            .|||||.||:||||||||||:|||||::|||.::|:.|..|||:.....| |||.||
Mosquito   586 PEEVRKTTSALQQSSLKLFEMAYKKMASEREGSSGSSSGSSSSTGSEEAE-KKENKN 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	548/614 (89%)
		HSPA9-like_NBD	51..428	CDD:212683	343/376 (91%)
		Syntaphilin	<566..>642	CDD:291936	54/75 (72%)
AgaP_AGAP010876	XP_309825.4	dnaK	7..612	CDD:234715	543/604 (90%)
		HSPA9-like_NBD	7..384	CDD:212683	343/376 (91%)
		DUF972	531..>608	CDD:283750	56/76 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	1063	1.000	Domainoid score	I116
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39452
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I726
OMA	1	1.010	-	-		QHG61239
OrthoDB	1	1.010	-	-		D237853at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	1	1.000	-	-		oto106662
Panther	1	1.100	-	-	LDO	PTHR19375
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1906
TreeFam	1	0.960	-	-
	13	12.940