DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hyou1

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_067370.3	Gene:	Hyou1 / 12282	MGIID:	108030	Length:	999	Species:	Mus musculus

Alignment Length:	774	Identity:	193/774 - (24%)
Similarity:	323/774 - (41%)	Gaps:	174/774 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AVIGIDLGTTNSCLAVME-GKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            ||:.:|||:.:..:|::: |...:::.|.|..|.||..|.. |:.||.:|..|...|:.|...|.
Mouse    34 AVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTL-KENERFLGDSAAGMAIKNPKATL 97

  Fly   117 YATKRLIGRRFDDPEVKKDITNLSYK--------VVKASNGDAWVSSTDGKVYSPSQIGAFILMK 173
            ...:.|:|::.|:|.|      ..|:        :|...........:....:||.::...:|..
Mouse    98 RYFQHLLGKQADNPHV------ALYRSRFPEHELIVDPQRQTVRFQISPQLQFSPEEVLGMVLNY 156

  Fly   174 MKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTED- 237
            .:..||.:...|:|:||:||||:||.::|:|...|.::|||.||::||:.||.||:||:.:.:|
Mouse   157 SRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDI 221

  Fly   238 ----KIIAVYDLGGGTFDISILEIQ---------KGVFEVKSTNGDTLLGGEDFD----NHIVNF 285
                :.:..||:|.|:...:|:..|         :...:::....|..|||.:.:    .|:...
Mouse   222 NSTAQNVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLREHLAKL 286

  Fly   286 LVAEFKKDSGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSK 350
            ...:.|.....|:|::..||.:|...|.:.|..||::......:..|..|.    ....|:||.:
Mouse   287 FNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDV----DFKAKVTRVE 347

  Fly   351 LESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQP-SRSVNPD 414
            .|.|..||..|...|.|:||..||:|..:|.:|:||||.||:||||..:.:..|::. .:::|.|
Mouse   348 FEELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINAD 412

  Fly   415 EAVAVGAAVQGGVL--AGDVTDVLLLDVTPLSLGIETLGGVFTR-----------------LISR 460
            ||.|:||..|...|  |..|...::.|.....:.:|     |||                 |.||
Mouse   413 EAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVE-----FTREVEEEPGLRSLKHNKRVLFSR 472

  Fly   461 NTTIPTKKSQVFSTASDGQTQVEIKVHQGEREM--ANDNKLLGSFTLV-----GIPPAPRGVPQ- 517
            ....|.:|...|:..|.   .....::.|:...  ..|.::.||..|.     |:..:.:..|.
Mouse   473 MGPYPQRKVITFNRYSH---DFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDY 534

  Fly   518 ----IEVVFDIDANGI-------------VHVSAKDKGTGKEQQIVIQS--SGGLSKDEIENMIK 563
                |:..|::|.:|:             |..|.:::.|..:....|.|  .||.|.|..||...
Mouse   535 ESKGIKAHFNLDESGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTD 599

  Fly   564 --KAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQLPAE-------------------- 606
              :.||.:.|:..|.|..|   ||| :..:.|...||.....|:|
Mouse   600 AVQEEEESPAEGSKDEPAE---QGE-LKEEAEPPAEETSQPPPSEPKGDAAREGEKPDEKESGDK 660

  Fly   607 -ECEK--------------------------LKKEIADLRTLLANKETADL-------------- 630
             |.:|                          .:|.:.::...||..:..||
Mouse   661 PEAQKPNEKGQAGPEGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEE 725

  Fly   631 --------EEVRKATSSLQ----QSSLKLFELAYKKMSAE--RESNAGAGSSDSSSSSD 675
                    :|..||.:||:    ::..||::..|:::|.|  ||..:|..|:.|:...|
Mouse   726 LTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLED 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	190/763 (25%)
		HSPA9-like_NBD	51..428	CDD:212683	119/402 (30%)
		Syntaphilin	<566..>642	CDD:291936	26/148 (18%)
Hyou1	NP_067370.3	HYOU1-like_NBD	36..424	CDD:212672	117/398 (29%)
		MDN1	<554..767	CDD:227596	42/216 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..694		26/130 (20%)
		PHA03169	<586..>691	CDD:223003	22/108 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900