DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and HSPA12B

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_443202.3	Gene:	HSPA12B / 116835	HGNCID:	16193	Length:	686	Species:	Homo sapiens

Alignment Length:	718	Identity:	141/718 - (19%)
Similarity:	236/718 - (32%)	Gaps:	252/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PKFLPRLARQAGVVPSHMSGASSMFRNLPGASNGISSQLRYKSGEVKGAVIGIDLGTTNSCLA-- 67
            |...||.....|:.|.             ..|.....::|.........|:.||.|||:|..|
Human    26 PPGSPRTQESCGIAPL-------------TPSQSPKPEVRAPQQASFSVVVAIDFGTTSSGYAFS 77

  Fly    68 -VMEGKQAKVIENAEGA------RTTPSHVAFTKDGERLVGMPAKRQAVTNSANTFYATKRLIGR 125
             ..:.:...::...||.      :.||:.:..|.:|               :.::|..|.|
Human    78 FASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEG---------------AFHSFGYTAR---- 123

  Fly   126 RFD-----DPEVKKD-------------ITNLSYKVVKASNGDAWVSSTDGKVYSPSQIGAFILM 172
              |     |||..:|             .|:|:.|        ..:.:.:||.....::.|..|.
Human   124 --DYYHDLDPEEARDWLYFEKFKMKIHSATDLTLK--------TQLEAVNGKTMPALEVFAHALR 178

  Fly   173 KMKETA-----EAYLNTPVKNA---VVTVPAYFNDSQRQATKDAGQIAGL------NVLRVINEP 223
            ..:|.|     |...:.|.|:.   |:||||.:....:|..::|..:|||      ..|.:..||
Human   179 FFREHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLLIALEP 243

  Fly   224 TAAAL---------------------AYGMDKTEDKII--------------------------- 240
            .||::                     ..|..::.|...
Human   244 EAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGVGELWA 308

  Fly   241 --------AVYDLGGGTFDISI--LEIQKGVFE--VKSTNG-----------DTLL---GGEDFD 279
                    .|.|.||||.|:::  ||...|..:  .|::.|           :.||   .||||
Human   309 EMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDF- 372

  Fly   280 NHIVNFLVAEFKKD---SGIDIRKDNIAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQH 341
                   :|.||:.   :.:|:   .||.:..|..|...:     :...:|:||:..:|....|.
Human   373 -------IATFKRQRPAAWVDL---TIAFEARKRTAGPHR-----AGALNISLPFSFIDFYRKQR 422

  Fly   342 MN---------------------LKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLL 385
            .:                     |:::...:..|....:...||..:..|:..||...::  :.|
Human   423 GHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALLARPEVQGVKL--LFL 485

  Fly   386 VGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAV-QGGVLAGDVTDVLLLDVTPLSLGIET 449
            |||......:|..||...|.:..|.|.|.:   ||..: :|.||.|....|:.:..:||:.|:..
Human   486 VGGFAESAVLQHAVQAALGARGLRVVVPHD---VGLTILKGAVLFGQAPGVVRVRRSPLTYGVGV 547

  Fly   450 LG----------------------GVFTRLIS--RNTTIPTKKSQVFSTASDGQTQVEIKVHQGE 490
            |.                      .||.|.::  ::..:..:..:.:..|..||.:|.|.::...
Human   548 LNRFVPGRHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCA 612

  Fly   491 REMAN-----DNKLLGSFTL-----------VGIPPAPR--------GVPQIEV-VFDIDANGIV 530
            .|.|.     ..:..|:.:|           .|.||..|        |..:|:| ..|:..|..|
Human   613 AEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTEIKVTAVDVSTNRSV 677

  Fly   531 HVS 533
            ..|
Human   678 RAS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	134/672 (20%)
		HSPA9-like_NBD	51..428	CDD:212683	103/516 (20%)
		Syntaphilin	<566..>642	CDD:291936
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..53		6/39 (15%)
HSPA12B	NP_443202.3	NBD_sugar-kinase_HSP70_actin	61..529	CDD:327376	105/517 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900