DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-5 and Hspa13

DIOPT Version :9

Sequence 1:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_084477.1	Gene:	Hspa13 / 110920	MGIID:	1309463	Length:	471	Species:	Mus musculus

Alignment Length:	423	Identity:	159/423 - (37%)
Similarity:	236/423 - (55%)	Gaps:	52/423 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VIGIDLGTTNSCLAVM---EGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115
            |||||||||...:.|.   .|| .|||.:..|..:.||.|:|| ||:..||..:...|.:|..||
Mouse    33 VIGIDLGTTYCSVGVFFPGTGK-VKVIPDENGHISIPSMVSFT-DGDVYVGYESLELADSNPQNT 95

  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVSSTDGK--VYSPSQIGAFILMKMKETA 178
            .|..||.||:.|...|::.::....:||:. .||.|..|.|..:  :.||..:|:.:|:|:||.|
Mouse    96 IYDAKRFIGKIFTPEELEAEVGRYPFKVLH-RNGMAEFSVTSNETIIVSPEFVGSRLLLKLKEMA 159

  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTEDKIIAVY 243
            |.||..||.|||::|||.|:..||.:|..|..:|||.:|||||||||||:|||:.|.:...:.|.
Mouse   160 EEYLGMPVANAVISVPAEFDLQQRNSTIQAANLAGLKILRVINEPTAAAMAYGLHKVDVFYVLVI 224

  Fly   244 DLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSG-IDIRKDNIAMQR 307
            ||||||.|:|:|..|.|:|..::.:|:..|||:||:..::..|..|..:..| :..||:.|  .|
Mouse   225 DLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQHLYKEIYQTYGFLPSRKEEI--HR 287

  Fly   308 LKEAAEKAKCELSSSQQTDINLPYLTM---DAAGPQ-----------------HMN--------- 343
            |::|.|..|..|:..|...::: .||:   |:..||                 |:|
Mouse   288 LRQAVEMVKLNLTIHQSAQVSV-LLTVEGKDSKEPQNGDSELPKDQLTPGDGHHVNRVFRPGLSE 351

  Fly   344 -----------LKLTRSKLESLVGDLIKRTIQPCQKALSDAEVSKSEIGEVLLVGGMTRMPKVQS 397
                       .:::|...::|..||.::.:.|.|:.|.:..:.|:||.||:||||.||:|:::.
Mouse   352 SKSGKSQVLFETEVSRKLFDALNEDLFQKILVPIQQVLKEGLLDKTEIDEVVLVGGSTRIPRIRQ 416

  Fly   398 TVQELFGRQPSRSVNPDEAVAVGAAVQGGVLAG 430
            .:||.||:.|:.||:||.||..|.|:|.|:..|
Mouse   417 VIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGG 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	159/423 (38%)
		HSPA9-like_NBD	51..428	CDD:212683	158/419 (38%)
		Syntaphilin	<566..>642	CDD:291936
Hspa13	NP_084477.1	HSPA13-like_NBD	12..463	CDD:212679	159/423 (38%)
		PRK13930	32..442	CDD:237564	155/414 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..350		5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910