Protein Alignment Hsc70-5 and hspa5

DIOPT Version :10

• Sequence 1: NP_523741.2
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_002941690.1
• Gene: hspa5 / 100492570
• XenbaseID: XB-GENE-480060
• Length: 655
• Species: Xenopus tropicalis
• Alignment Length: 649
• Identity: 319/649 - (49%)
• Similarity: 434/649 - (66%)
• Gaps: 40/649 - (6%)

  Fly    52 GAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANTF 116
            |.|:|||||||.||:.|.:..:.::|.|.:|.|.|||:||||.:||||:|..||.|..:|..||.
 Frog    30 GTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTV 94

  Fly   117 YATKRLIGRRFDDPEVKKDITNLSYKVVKASN--------GDAWVSSTDGKVYSPSQIGAFILMK 173
            :..||||||.::||.|::||..|.:||::...        ||..      |.::|.:|.|.:|:|
 Frog    95 FDAKRLIGRTWNDPSVQQDIKYLPFKVIERKTKPYIQVDIGDQM------KTFAPEEISAMVLVK 153

  Fly   174 MKETAEAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-D 237
            |||||||||...|.:|||||||||||:|||||||||.||||||:|:||||||||:|||:||.| :
 Frog   154 MKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKKEGE 218

  Fly   238 KIIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDN 302
            |.|.|:||||||||:|:|.|..|||||.:|||||.|||||||..::...:..:||.:|.|:||||
 Frog   219 KNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDN 283

  Fly   303 IAMQRLKEAAEKAKCELSSSQQTDINLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQ 367
            .|:|:|:...||||..|||..|:.|.:......    :..:..|||:|.|.|..||.:.|::|.|
 Frog   284 RAVQKLRREVEKAKRALSSQHQSRIEIESFFEG----EDFSETLTRAKFEELNMDLFRSTMKPVQ 344

  Fly   368 KALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAG- 430
            |.|.||::.||:|.|::||||.||:||:|..|:|.| |::|||.:|||||||.|||||.|||:|
 Frog   345 KVLDDADLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGD 409

  Fly   431 -DVTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494
             |..|::||||.||:|||||:|||.|:||.|||.:||||||:||||||.|..|.|||::|||.:.
 Frog   410 QDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLT 474

  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558
            .||.|||:|.|.||||||||||||||.|:||.|||:.|:|:|||||.:.:|.| .....|:.:||
 Frog   475 KDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEI 539

  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKM---EEFKSQLPAEECEKLKKEIADLRT 620
            |.|:..||::|..||:.:|.|:..|:.||..:..:.::   |:...:|.:|:.|.::|.:.:...
 Frog   540 ERMVTDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETIEKAVEEKIE 604

  Fly   621 LLANKETADLEEVRKATSSLQQSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEE 684
            .|.:.:.:|:||.:.....|::....:....|          .|||:.....:.:|    :|:|
 Frog   605 WLESHQDSDIEEFKAKKKELEEIVQPIVGKLY----------GGAGAPPPEGAEET----EKDE 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-5	NP_523741.2	dnaK	51..666	CDD:234715	314/629 (50%)
hspa5	XP_002941690.1	HSP70	32..636	CDD:394970	311/613 (51%)