Protein Alignment Mdr50 and mdlA

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_414982.1
• Gene: mdlA / 945092
• ECOCYCID: G6248
• Length: 590
• Species: Escherichia coli
• Alignment Length: 567
• Identity: 160/567 - (28%)
• Similarity: 268/567 - (47%)
• Gaps: 88/567 - (15%)

  Fly   135 ISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQ 199
            |:|::|            |.:::.:..|:.......|::...:.:|..::|.:..|..::|..::
E. coli    60 IATMVL------------IAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHR 112

  Fly   200 SGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVK---GWQLSLVCLTSLPLTFIAM 261
            :|::.:|...|:.::.....|.|:..|..||  :|..||..:.   .|||:|..|..:|:..|.:
E. coli   113 TGDLMARATNDVDRVVFAAGEGVLTLVDSLV--MGCAVLIMMSTQISWQLTLFSLLPMPVMAIMI 175

  Fly   262 GLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY--------KERVVAAKI 318
            .....|.....|.....::......:.:|:.||.:|||..|.::.|.:        |:.:..|:|
E. coli   176 KRNGDALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARI 240

  Fly   319 -LNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSM 382
             ......::..||...|         ||...|..:|::                        ||:
E. coli   241 DARFDPTIYIAIGMANL---------LAIGGGSWMVVQ------------------------GSL 272

  Fly   383 NIGMAAPYIEAFGI---AKGACAKVFHIIE--------------QIPEINPIDGEGKKLNEPLT- 429
            .:|....::...|:   ...|.|.:|:|:|              :.|.:|  ||     :||:.
E. coli   273 TLGQLTSFMMYLGLMIWPMLALAWMFNIVERGSAAYSRIRAMLAEAPVVN--DG-----SEPVPE 330

  Fly   430 ---TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLL 491
               .::....:|.|| :.:...|..:|..:..||.:.:.||:|.||||.:.|:||.:|...|::.
E. coli   331 GRGELDVNIHQFTYP-QTDHPALENVNFALKPGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIR 394

  Fly   492 FNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLP 556
            |:...|..|.::..|||:.||.|.|.||:.::..||..|..:||::|||..|..|:....|.:||
E. coli   395 FHDIPLTKLQLDSWRSRLAVVSQTPFLFSDTVANNIALGCPNATQQEIEHVARLASVHDDILRLP 459

  Fly   557 KGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTT 621
            :||||.|||||..|||||||||:|||||:.:.|||:||:|.||:|..:|.::...|.:...|||.
E. coli   460 QGYDTEVGERGVMLSGGQKQRISIARALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTV 524

  Fly   622 IIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ 668
            ||.|||||.:..|..|:|:..|.:.:.|.|..|.:....|.::...|
E. coli   525 IISAHRLSALTEASEIIVMQHGHIAQRGNHDVLAQQSGWYRDMYRYQ 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	160/567 (28%)
mdlA	NP_414982.1	PRK10789	22..590	CDD:182732	160/567 (28%)