DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB11

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_011510379.1	Gene:	ABCB11 / 8647	HGNCID:	42	Length:	1355	Species:	Homo sapiens

Alignment Length:	1341	Identity:	539/1341 - (40%)
Similarity:	785/1341 - (58%)	Gaps:	103/1341 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DRDRKSFEPNKSKKKSKHDESD----ASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLL 93
            ::.|.|:...|.:||..::.:|    ..||:.|     |..:|.:|||||:::..|..|..:|.|
Human    42 NKSRTSWSSFKEQKKISNNNNDKKSRLQDEKKG-----DGVRVGFFQLFRFSSSTDIWLMFVGSL 101

  Fly    94 SAVATGLTTPANSLIFGNLANDMID----LGGLLESGKSYRADDAIST---------------LL 139
            .|...|:..|...||||.:.:..||    |..|...||:...:..:.|               ||
Human   102 CAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLL 166

  Fly   140 LDKVRQFSLQNTYIGI--IMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGE 202
            ..:.......:.|.||  .:|:..|:.|..:..||..||..:|..:||.|:..::.|:|.|..||
Human   167 NIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGE 231

  Fly   203 VASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVA 267
            :.:|.::|::|:.|.:|:::.:|:..:.:.:...:|.|.:||:|:||.::..||..|....:.::
Human   232 LNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLS 296

  Fly   268 TSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFG 332
            .|:....|:..||.|.|||:..:|.:|||.||.||.:||..|::.:|.|:...|::.:..|...|
Human   297 VSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTG 361

  Fly   333 LLWFFIYASYALAFWYGVGLVI-KGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGI 396
            .:|..|:..||||||||..||: :|.:.|       ||::.:|.||::|::|:|.|:|.:|||..
Human   362 FVWCLIFLCYALAFWYGSTLVLDEGEYTP-------GTLVQIFLSVIVGALNLGNASPCLEAFAT 419

  Fly   397 AKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQT 461
            .:.|...:|..|::.|.|:.:..:|.||:.....|||..|.|.||:||||.|||.||:.|..|:.
Human   420 GRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEM 484

  Fly   462 VALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYEN 526
            .|||||||.||||.:||:||||||..|.:..:|.:::.|:|.|||.:||:|.|||:||:|:|.||
Human   485 TALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAEN 549

  Fly   527 IRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEIL 591
            |||||||||.|:|..||..|||..||..||:.:||||||.|.|:|||||||:||||||||:|:||
Human   550 IRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKIL 614

  Fly   592 LLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELME 656
            |||.||||||..|||.||..|.|:..|.|.|.|||||||||.||.|:....|..||.|||:||:|
Human   615 LLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLE 679

  Fly   657 LKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEI--KVLSEDEDED------------ 707
            .|..||.|||.|         |.........||||..|:::  :..|....:|
Human   680 RKGVYFTLVTLQ---------SQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKS 735

  Fly   708 ----------VMVTDEKNKKKKKKKVKD---PNEVK--PMLEVMKMNKPEWLQIAVGCISSVIMG 757
                      :.|.|.|:..::.:|.||   ..||:  |:..::|.:.|||..:.||.:.:.:.|
Human   736 QLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNG 800

  Fly   758 CAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTER 822
            ...|::|.||..||...|:.|.::. |...|...|.|:..|.|.....|||.|.|..:||.||:|
Human   801 TVTPLYAFLFSQILGTFSIPDKEEQ-RSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKR 864

  Fly   823 LRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMY 887
            ||...|.|||.|::|||||..|..|:|..||:.||:.||||.|.:||.||.|.:.:.:.:.::..
Human   865 LRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFS 929

  Fly   888 YEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFH 952
            :.|.|.||.|.|.||:.::...|..::........:.:|...::..|.:|||||||.:|:|..|
Human   930 FSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRF- 993

  Fly   953 QNYIGMLIPAVE----------ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFG 1007
                   |.|:|          |.|.|.:  |..:..|:.:||.|.:|...||.:.:.:.|:.|.
Human   994 -------IEALETELEKPFKTAIQKANIY--GFCFAFAQCIMFIANSASYRYGGYLISNEGLHFS 1049

  Fly  1008 DVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQP--SIVDRPGVSRDPWHS-EGY 1069
            .||:|..|:::...::..|.::.|:..|...:|...|..|.|||  |:.:..|   :.|.: :|.
Human  1050 YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAG---EKWDNFQGK 1111

  Fly  1070 VRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDEC 1134
            :.|...||:||:|.:.|||.||.:::|.||.:|.||.|||||||.|||::||||.|:|..:||..
Human  1112 IDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGH 1176

  Fly  1135 DVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLG 1199
            |.:.|::..||:.:|||||||:||..:|.:||.||||.:.:..:.:|:|.|::.:|:|:.:||..
Human  1177 DSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1241

  Fly  1200 YDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTIS 1264
            |:|.:|.:|:|||.|:|||||||||::|:|||:||||||||||.||||.||.|||.|.||||.|.
Human  1242 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1306

  Fly  1265 IAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305
            |||||||:.::|:|.|...|:|.|.|.|::|:|.:|.||.|
Human  1307 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	529/1301 (41%)
		ABC_membrane	92..382	CDD:279056	96/311 (31%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	148/236 (63%)
		ABC_membrane	750..1020	CDD:279056	95/279 (34%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	129/236 (55%)
ABCB11	XP_011510379.1	PTZ00265	52..1348	CDD:240339	537/1331 (40%)
		ABC_membrane	101..405	CDD:279056	96/310 (31%)
		ABC_MTABC3_MDL1_MDL2	454..691	CDD:213216	148/236 (63%)
		ABC_membrane	794..1043	CDD:279056	89/259 (34%)
		ABC_MTABC3_MDL1_MDL2	1112..1351	CDD:213216	129/236 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2842
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1026	1.000	Inparanoid score	I275
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm40248
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.910