Protein Alignment Mdr50 and MDL2

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_015053.2
• Gene: MDL2 / 855858
• SGDID: S000006191
• Length: 773
• Species: Saccharomyces cerevisiae
• Alignment Length: 620
• Identity: 191/620 - (30%)
• Similarity: 298/620 - (48%)
• Gaps: 76/620 - (12%)

  Fly   718 KKKKKVKDPNEVKPMLEVMKMNKPEW-------LQIAVGCISSVIMGCAMPIFAVLFGSILQILS 775
            |::.|..|   .|.::.:..:.|.:|       |.:.:.|    .:|.::|   .:.|.:|..|.
Yeast    94 KEQSKTDD---YKDIIRLFMLAKRDWKLLLTAILLLTISC----SIGMSIP---KVIGIVLDTLK 148

  Fly   776 VKDNDQYVRENSNQYSL-------YFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLR 833
            ......:.......:||       :|.:|.::...|.|.:.....|..||:..|||..:.:..|.
Yeast   149 TSSGSDFFDLKIPIFSLPLYEFLSFFTVALLIGCAANFGRFILLRILSERVVARLRANVIKKTLH 213

  Fly   834 QEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALA 898
            |:..:||:  :..|.|.:||..||..|..:..|::...|:::....:|:.:.......|.::.|.
Yeast   214 QDAEFFDN--HKVGDLISRLGSDAYVVSRSMTQKVSDGVKALICGVVGVGMMCSLSPQLSILLLF 276

  Fly   899 FTPFILIAFYMQRTLMAKENMGSAKTMENC----TKLAVEVVSNIRTVASLGREEMFHQNYIGML 959
            |||.:|.:    .::..|:...::|.::..    |::|.|.:|.|:||.|...|
Yeast   277 FTPPVLFS----ASVFGKQIRNTSKDLQEATGQLTRVAEEQLSGIKTVQSFVAE----------- 326

  Fly   960 IPAVEISKRNTHFRGLVYGLARSLMF--------------FAYAACMYYGTWCVIHRGILFGDVF 1010
              ..|:|:.|...|. ::.:.::..|              .::...:.||::.|:...:..||:
Yeast   327 --GNELSRYNVAIRD-IFQVGKTAAFTNAKFFTTTSLLGDLSFLTVLAYGSYLVLQSQLSIGDL- 387

  Fly  1011 KVSQALIMGTASIANAL----AFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVR 1071
               .|.::.|....||:    .|...:.:|..||..:|....|:|||....|....|  ..|.:.
Yeast   388 ---TAFMLYTEYTGNAVFGLSTFYSEIMQGAGAASRLFELTDRKPSISPTVGHKYKP--DRGVIE 447

  Fly  1072 FDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV 1136
            |..|.||||||..:|:.|.|...::.|..:.:|||||.||||...|:.|:|:...|...||..|:
Yeast   448 FKDVSFSYPTRPSVQIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYYNPTTGTITIDNQDI 512

  Fly  1137 RNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYD 1201
            ..::..:||..:|||.|||:|...|||:||:|| .....|.:||.|..|:...|.||...|..||
Yeast   513 SKLNCKSLRRHIGIVQQEPVLMSGTIRDNITYG-LTYTPTKEEIRSVAKQCFCHNFITKFPNTYD 576

  Fly  1202 TRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALD--AASEGRTTIS 1264
            |.:|..|..||||||||||||||||:.|.|::|||||||||.|||..:.....  ..|:..|.:|
Yeast   577 TVIGPHGTLLSGGQKQRIAIARALIKKPTILILDEATSALDVESEGAINYTFGQLMKSKSMTIVS 641

  Fly  1265 IAHRLSTVVHSD-VIFVFENGLVCEAGDHKQLLAN 1298
            |||||||:..|: ||.:..:|.|.|.|..|:|.||
Yeast   642 IAHRLSTIRRSENVIVLGHDGSVVEMGKFKELYAN 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	191/620 (31%)
		ABC_membrane	92..382	CDD:279056
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216
		ABC_membrane	750..1020	CDD:279056	60/294 (20%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	109/232 (47%)
MDL2	NP_015053.2	3a01208	1..685	CDD:273363	191/620 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I944
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810