DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr50 and STE6

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_012713.1 Gene:STE6 / 853671 SGDID:S000001692 Length:1290 Species:Saccharomyces cerevisiae


Alignment Length:1327 Identity:362/1327 - (27%)
Similarity:612/1327 - (46%) Gaps:129/1327 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 KQVSYFQLFRYAT-KKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRAD 132
            |...::.:|||.. :.|..|.:|.::..|||||.....|::.|.    :.||..:..:..|::. 
Yeast     7 KTTKHYHIFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGR----VFDLLSVFVANGSHQG- 66

  Fly   133 DAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQ-DMKWYD 196
                  |..::.|.|:....:|...:...:||:|.:.:....|...|||:...:.|.: .|:|||
Yeast    67 ------LYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYD 125

  Fly   197 FNQS--GEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLP-LTF 258
            .|:.  |:. :::|..:.::....||...:....|||....|..:|...|.|:|:.|.|.| :||
Yeast   126 NNEKLLGDF-TQINRCVEELRSSSAEASAITFQNLVAICALLGTSFYYSWSLTLIILCSSPIITF 189

  Fly   259 IAMGLVAVATSRL----AKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKIL 319
            .     ||..||:    ::||.:..:.||.:...:::..:.|:.:..:..|...:||.::.....
Yeast   190 F-----AVVFSRMIHVYSEKENSETSKAAQLLTWSMNAAQLVRLYCTQRLERKKFKEIILNCNTF 249

  Fly   320 NIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFS-VMMGS-M 382
            .||...|.....|:|.|.....:...||:|..::.||       ..:...:||.|.| :|:|| :
Yeast   250 FIKSCFFVAANAGILRFLTLTMFVQGFWFGSAMIKKG-------KLNINDVITCFHSCIMLGSTL 307

  Fly   383 NIGMAAPYIEAFGIAKGACA--KVFHIIEQIPEINPID---GEGKKLNEPLTTIEFKEVEFQYPT 442
            |..:....:    :.||..|  |:..:::...:.||::   .....|:...:.:.|..|.|.||:
Yeast   308 NNTLHQIVV----LQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQFPLDYATSDLTFANVSFSYPS 368

  Fly   443 RPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRS 507
            ||..::|..::|....||...:||.||.||||...|:.||||...|::..||.|::.:|...|..
Yeast   369 RPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIE 433

  Fly   508 RIGVVGQEPILFATSIYENIRYGREDATREE----------IEAAAAAANAAIFIKKLPKGYDTL 562
            .|.||.|...||..::.:||..|..|:.|..          |:.|...|....||..||.|.:||
Yeast   434 NITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETL 498

  Fly   563 VGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHR 627
            :|..|..|||||:||:|||||.|||..||.||||.||||......:..|:.....|:||||:.|.
Yeast   499 IGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHE 563

  Fly   628 LSTVRRADRIVVINKGEVVESGTHQELM-----------ELKDHYFN---LVTTQLGEDD----- 673
            ||.:...|.:.::.:||||||||..||:           .|::.|.:   :|.|:..|..     
Yeast   564 LSQIESDDYLYLMKEGEVVESGTQSELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEKSIHTVE 628

  Fly   674 -----------GSVLSPTG-------DIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKK- 719
                       ||.||..|       ..|:....|..:....:|..|:|:....:..:||.:.. 
Yeast   629 SFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQKNTESST 693

  Fly   720 -KKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQ-ILSVKDNDQY 782
             .:.:.....:|.|::.::..|    .:.:|.:.|:|.|...|:|:..|..:|: |:...|.   
Yeast   694 GPQLLSIIQIIKRMIKSIRYKK----ILILGLLCSLIAGATNPVFSYTFSFLLEGIVPSTDG--- 751

  Fly   783 VRENSNQY----SLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKA 843
             :..|:.|    ||..|......||..|.:.:......|.....||..:.|.:.|:.:.||..:.
Yeast   752 -KTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNEVMEKLTRKNMDWFSGEN 815

  Fly   844 NGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFY 908
            |....:.|.:..|...::....:.:..:...::...:|:..::...|.|.||.::..|.|:|...
Yeast   816 NKASEISALVLNDLRDLRSLVSEFLSAMTSFVTVSTIGLIWALVSGWKLSLVCISMFPLIIIFSA 880

  Fly   909 MQRTLMAK---ENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNT 970
            :...::.|   :...|...:|||   ..::|:||:|:..|..|..|...|..:.|...:|:.:..
Yeast   881 IYGGILQKCETDYKTSVAQLENC---LYQIVTNIKTIKCLQAEFHFQLTYHDLKIKMQQIASKRA 942

  Fly   971 HFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQK 1035
            ...|....:...::....|...|||...|:.......::|.....|:....|..:.::..|::.:
Yeast   943 IATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKEMFTTFTLLLFTIMSCTSLVSQIPDISR 1007

  Fly  1036 GVSAAKTIFTFLRRQPSIVD-------RPGVSRDPWH---SEGYVRFDKVKFSYPTRSEIQVLKG 1090
            |..||..|:..|..:.:.::       ..|::...:|   .:..|....:.|:||:.....|.|.
Yeast  1008 GQRAASWIYRILDEKHNTLEVENNNARTVGIAGHTYHGKEKKPIVSIQNLTFAYPSAPTAFVYKN 1072

  Fly  1091 LELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEP 1155
            :...:..||.:.::|.||.||||.:.|:.:.|:.:.|...||..||.:.::|:||.::.:|.|:|
Yeast  1073 MNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKP 1137

  Fly  1156 ILFDRTIRENISYG--DNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQR 1218
            :||:.|||:|::||  |   .:.:.|:..|.|...||:|:.:.|.|.|||:..  ..|||||.||
Yeast  1138 LLFNGTIRDNLTYGLQD---EILEIEMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQR 1197

  Fly  1219 IAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFEN 1283
            :.|||||:|..||::|||.|||||:.|..::.:.:........|:.|.|....:...:.|.|.::
Yeast  1198 LCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKD 1262

  Fly  1284 GLVCEAGDHKQLLANRGLYYTLYKLQS 1310
            |.|.|.|:...|..|||..:.:...||
Yeast  1263 GKVVERGNFDTLYNNRGELFQIVSNQS 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 360/1323 (27%)
ABC_membrane 92..382 CDD:279056 74/299 (25%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 101/260 (39%)
ABC_membrane 750..1020 CDD:279056 58/277 (21%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 85/240 (35%)
STE6NP_012713.1 MdlB 24..605 CDD:224055 182/608 (30%)
MdlB 702..1289 CDD:224055 156/602 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 76 1.000 Domainoid score I2107
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 448 1.000 Inparanoid score I251
Isobase 1 0.950 - 0 Normalized mean entropy S1571
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm46468
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
TreeFam 1 0.960 - -
109.670

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