DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr50 and MDL1

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_013289.1	Gene:	MDL1 / 850885	SGDID:	S000004178	Length:	695	Species:	Saccharomyces cerevisiae

Alignment Length:	692	Identity:	207/692 - (29%)
Similarity:	346/692 - (50%)	Gaps:	77/692 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDDVNSRSQYKTNIVLGAKLEDSD--RDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVS 72
            |.::|....::.:.:|.:....||  :.:||.:|....       |:|:.:..|   .:|:|::
Yeast    39 KAEINLIIPHRKHFLLRSIRLQSDIAQGKKSTKPTLKL-------SNANSKSSG---FKDIKRL- 92

  Fly    73 YFQLFRYATKKDRALYV-IGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESG-KSYRADDAI 135
                  :...|..:.|: :.||..:.:...:.|...:.|.|.:...:..|..|.| ||
Yeast    93 ------FVLSKPESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEEGSKS------- 144

  Fly   136 STLLLDKVRQFSLQN--TYIG---IIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWY 195
                 :|:..|:.:.  |.:|   ||..|.:...|..........:..:|::..::.|.||..:.
Yeast   145 -----NKLYGFTKKQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFL 204

  Fly   196 DFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLV-AFVGSLVLAFVKGWQLSLVCLTSLPLTFI 259
            |.|:.|::.||::.|.|.:...:.:.|......:: .|||..:::|: .|:|:.|.:...|
Yeast   205 DTNRVGDLISRLSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFL-SWKLTCVMMILAP---- 264

  Fly   260 AMGLVAVATSR----LAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILN 320
            .:|.:|:...|    |:::..|...|...|||..|:..||::|:.||..||..|.:.|.....:.
Yeast   265 PLGAMALIYGRKIRNLSRQLQTSVGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIG 329

  Fly   321 IKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNI 384
            :|..:.||:.||........:.......|..::..|       :...|.:.: :.::|..||...
Yeast   330 LKEAVTSGLFFGSTGLVGNTAMLSLLLVGTSMIQSG-------SMTVGELSSFMMYAVYTGSSLF 387

  Fly   385 GMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT----TIEFKEVEFQYPTRPE 445
            |:::.|.|....| ||.|:||.:.::.|.|.|..|:     :|::    .|.||.|.|.|||||:
Yeast   388 GLSSFYSELMKGA-GAAARVFELNDRKPLIRPTIGK-----DPVSLAQKPIVFKNVSFTYPTRPK 446

  Fly   446 VSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIG 510
            ..|...||:.|..|:.|..|||||.||||...|:.|:||..:|::.|...::::.::...|..||
Yeast   447 HQIFKDLNITIKPGEHVCAVGPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIG 511

  Fly   511 VVGQEPILFATSIYENIRY------GREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQ 569
            .|.|||:||..:|.:||.|      ..:|   :.|..|...||...|:...|.|..|:||.||||
Yeast   512 YVQQEPLLFNGTILDNILYCIPPEIAEQD---DRIRRAIGKANCTKFLANFPDGLQTMVGARGAQ 573

  Fly   570 LSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALE-KVSAGRTTIIVAHRLSTVRR 633
            ||||||||||:|||.:.||.:|:|||||||||:.||..|...|: :|..|.|||.:||||||::.
Yeast   574 LSGGQKQRIALARAFLLDPAVLILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKH 638

  Fly   634 ADRIVVINK-GEVVESGTHQELMELKDHYFNLVTTQLGEDDG 674
            :.|::|:.| |.|||:|:.::|:.:.:...|.:..:..:::|
Yeast   639 STRVIVLGKHGSVVETGSFRDLIAIPNSELNALLAEQQDEEG 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	195/631 (31%)
		ABC_membrane	92..382	CDD:279056	67/301 (22%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	109/244 (45%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
MDL1	NP_013289.1	MdlB	116..676	CDD:224055	189/592 (32%)
		ABC_membrane	116..386	CDD:279056	66/293 (23%)
		ABC_MTABC3_MDL1_MDL2	432..676	CDD:213216	109/246 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I2757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810