DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB11

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001322407.1	Gene:	ABCB11 / 839353	AraportID:	AT1G02520	Length:	1278	Species:	Arabidopsis thaliana

Alignment Length:	1308	Identity:	501/1308 - (38%)
Similarity:	764/1308 - (58%)	Gaps:	57/1308 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVI 90
            ||:    :.|..|.||:.||...:.:|:...::.:     |....|.:::||.:|...|..|.:.
plant     5 GAR----EGDSVSHEPSTSKSPKEGEETKKEEKSE-----EKANTVPFYKLFAFADSSDVLLMIC 60

  Fly    91 GLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGI 155
            |.:.|:..|::.|..:|:||    |:||..|..::.|.          ::|.|.:..|:..|:|:
plant    61 GSIGAIGNGMSLPFMTLLFG----DLIDSFGKNQNNKD----------IVDVVSKVCLKFVYLGL 111

  Fly   156 IMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDF-NQSGEVASRMNEDLSKMEDGLA 219
            ..|..::|.:.|:......|...|||.:.::||.||:.::|. ..:|||..||:.|...::|.:.
plant   112 GTLGAAFLQVACWMITGERQAARIRSTYLKTILRQDIGFFDVETNTGEVVGRMSGDTVLIQDAMG 176

  Fly   220 EKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAV 284
            |||..|:..:..|||..||||:|||.|:||.|||:||..:|...:|:..:|.:.:....||.||.
plant   177 EKVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAAT 241

  Fly   285 VAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYG 349
            |.|..:..||||.:|.||.:.:.:||:.:.:|...:|::...:|:|.|:::|..::|||||.|:|
plant   242 VVEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFG 306

  Fly   350 VGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI 414
            ..::::       :.|..|.:|.|...|:.|||::|..:|.:.||...:.|..|:|..|::.|.|
plant   307 GKMILE-------KGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLI 364

  Fly   415 NPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLV 479
            :..|..||.|.:....||.|:|.|.||.||:..|.:..:|.|..|.|.||||.||.||||.|.|:
plant   365 DAYDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLI 429

  Fly   480 QRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAA 544
            :|||||::|.:|.:|.|||:..:.|:||:||:|.|||:||::||.|||.||:|:||.|||:||..
plant   430 ERFYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATE 494

  Fly   545 AANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQ 609
            .||||.||.|||:|.||:|||.|.|||||||||||||||:::||.||||||||||||..||..||
plant   495 LANAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQ 559

  Fly   610 AALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDH---YFNLVTTQ-LG 670
            .||::|...|||:||||||||||.||.|.||::|::||.|:|.||  |||.   |..|:..| :.
plant   560 EALDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSEL--LKDSEGAYSQLIRLQEIN 622

  Fly   671 EDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMV------------TDEKNKKKKKKKV 723
            :|..:....:|..::|.::|...|....|.:......:.|            :....:.:.....
plant   623 KDVKTSELSSGSSFRNSNLKKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQRAGQDETGTAS 687

  Fly   724 KDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSN 788
            ::|.....:..:..:||||...:.:|.:::.|.|...|:|.:|...:::......::  ::.:|.
plant   688 QEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFFKPAHE--LKRDSR 750

  Fly   789 QYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARL 853
            .:::.|:..|:...|.:..|:|.|.:||.:|..|:|.:.||..:..||||||:..|.:|::.|||
plant   751 FWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHMEVAWFDEPQNSSGTMGARL 815

  Fly   854 SGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKEN 918
            |.||..::...|..:...||::::.|.|:.::....|.|.|:.|...|.|.|..::|...|...:
plant   816 SADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVMLPLIGINGFVQVKFMKGFS 880

  Fly   919 MGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSL 983
            ..:....|..:::|.:.|.:||||||...||...|.|.......::...:.....||.:|.:..:
plant   881 ADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQCEGPIKDGIKQGFISGLGFGFSFFI 945

  Fly   984 MFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLR 1048
            :|..||...|.|...|......|.:||:|..||.|....|:.:..|||:..|...||.:||..:.
plant   946 LFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIID 1010

  Fly  1049 RQPSI--VDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGK 1111
            |:..|  .|..|...:  :.:|.:....:.|:||.|.:||:.:.|.|.:..|:.:||||.||.||
plant  1011 RKSKIDSSDETGTVLE--NVKGDIELRHLSFTYPARPDIQIFRDLCLTIRAGKTVALVGESGSGK 1073

  Fly  1112 STCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARN-V 1175
            ||.|.|:|||||.|.|...:|..:::.:.:..||.|:|:|.|||:||:.|||.||:||..:.. .
plant  1074 STVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAA 1138

  Fly  1176 TDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSA 1240
            |:.|||:|.:.:|.|:||:::..||||.:||:|.|||||||||:|||||:::.|||:||||||||
plant  1139 TESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSA 1203

  Fly  1241 LDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL-ANRGLYYT 1304
            ||||||:|||||||.....||||.:||||||:.::|||.|.:||::.|.|.|:.|: ...|:|.:
plant  1204 LDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLIKIEGGVYAS 1268

  Fly  1305 LYKLQSGA 1312
            |.:|...|
plant  1269 LVQLHMTA 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	489/1259 (39%)
		ABC_membrane	92..382	CDD:279056	94/290 (32%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	145/239 (61%)
		ABC_membrane	750..1020	CDD:279056	76/269 (28%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	123/240 (51%)
ABCB11	NP_001322407.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55496
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740