DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB12

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_171754.1	Gene:	ABCB12 / 839282	AraportID:	AT1G02530	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1295	Identity:	496/1295 - (38%)
Similarity:	746/1295 - (57%)	Gaps:	65/1295 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ESDA-SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAND 115
            |.|: |.|...|:..|..|.|..::||.:|...|..|.:.|.|.|:..|:..|..:|:||    |
plant     8 EGDSVSHEHSTSKTDEKAKTVPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMTLLFG----D 68

  Fly   116 MIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIR 180
            :||..|..::.|.          ::|.|.:..|:..|:|:..|..::|.:.|:......|...||
plant    69 LIDSFGKNQNNKD----------IVDVVSKVCLKFVYLGLGRLGAAFLQVACWMITGERQAAKIR 123

  Fly   181 SKFFRSILHQDMKWYDF-NQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGW 244
            |.:.::||.||:.::|. ..:|||..||:.|...::|.:.|||..|:..:..|||...|||.|||
plant   124 SNYLKTILRQDIGFFDVETNTGEVVGRMSGDTVHIQDAMGEKVGKFIQLVSTFVGGFALAFAKGW 188

  Fly   245 QLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAY 309
            .|:||.|||:|...:|...:|:..:|.:.:....||.||.|.|..:..||||.:|.||.:.:.:|
plant   189 LLTLVMLTSIPFLAMAGAAMALLVTRASSRGQAAYAKAATVVEQTIGSIRTVASFTGEKQAINSY 253

  Fly   310 KERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVF 374
            |:.:.:|...:|::...:|:|.|::.:..::|||||.|:|..::::       :.|..|::|.|.
plant   254 KKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSYALAIWFGGKMILE-------KGYTGGSVINVI 311

  Fly   375 FSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQ 439
            ..|:.|||::|..:|.:.||...:.|..|:|..|::.|.|:..|..||.|.:....||.|:|.|.
plant   312 IIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDAYDVNGKVLGDIRGDIELKDVHFS 376

  Fly   440 YPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINW 504
            ||.||:..|.:..:|.|..|.|.||||.||.||||.|.|::|||||:||.:|.:|.|||:..:.|
plant   377 YPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVINLIERFYDPKAGEVLIDGINLKEFQLKW 441

  Fly   505 LRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQ 569
            :||:||:|.|||:||::||.|||.||:|:||.:||:.|...||||.||..||:|.||.|||.|.|
plant   442 IRSKIGLVCQEPVLFSSSIMENIAYGKENATLQEIKVATELANAAKFINNLPQGLDTKVGEHGTQ 506

  Fly   570 LSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRA 634
            ||||||||||||||:::||.:||||||||||||.||..||.||::|...|||::|||||||||.|
plant   507 LSGGQKQRIAIARAILKDPRVLLLDEATSALDTESERVVQEALDRVMVNRTTVVVAHRLSTVRNA 571

  Fly   635 DRIVVINKGEVVESGTHQELMELKDH---YFNLVTTQ---LGED--------------------- 672
            |.|.||:.|::||.|:|.||  |||.   |..|:..|   .|.|
plant   572 DMIAVIHSGKMVEKGSHSEL--LKDSVGAYSQLIRCQEINKGHDAKPSDMASGSSFRNSNLNISR 634

  Fly   673 DGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEK-NKKKKKKKVKDPNEVKPMLEVM 736
            :|||:|.....:.|    ......:.||......|:....:: .:::.....::|.....:..:.
plant   635 EGSVISGGTSSFGN----SSRHHSLNVLGLFAGLDLGSGSQRVGQEETGTTSQEPLRKVSLTRIA 695

  Fly   737 KMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVV 801
            .:||||...:.:|.:.:.|.|...|:|.:|...:::.. .|..|| ::::|..:::.|:..|:..
plant   696 ALNKPEIPVLLLGTVVAAINGAIFPLFGILISRVIEAF-FKPADQ-LKKDSRFWAIIFVALGVTS 758

  Fly   802 GIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQ 866
            .|.:..|:|.|.:||.:|..|::.:.||..:..||:|||:..|.:|::.||||.|||.::...|.
plant   759 LIVSPSQMYLFAVAGGKLIRRIQSMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGD 823

  Fly   867 RIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKL 931
            .:...||:.::.|.|:.::....|.|.|:.|...|.|.|..::|...|...:..:....|..:::
plant   824 ALSLAVQNAASAASGLIIAFTASWELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQV 888

  Fly   932 AVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGT 996
            |.:.|.:||||||...||...|.|.......::...:.....||.:|.:..::|..||...|...
plant   889 ANDAVGSIRTVASFCAEEKVMQMYNKQCEGPIKDGVKQGFISGLGFGFSFFILFCVYATSFYAAA 953

  Fly   997 WCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSI--VDRPGV 1059
            ..|......|.|||:|..||.|....|:.:..|||:..|...||.:||..:.|:..|  .|..|.
plant   954 RLVEDGKTTFIDVFQVFFALTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGT 1018

  Fly  1060 SRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDV 1124
            ..:  :.:|.:....:.|:||.|..||:.:.|.|.:..|:.:||||.||.||||.|.|:|||||.
plant  1019 VLE--NVKGDIELRHLSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDP 1081

  Fly  1125 DEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARN-VTDQEIISACKKSN 1188
            |.|...:|..:::.:.:..||.|:|:|.|||:||:.|||.||:||..:.. .|:.|||:|.:.:|
plant  1082 DSGQITLDGVELKKLQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELAN 1146

  Fly  1189 IHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDAL 1253
            .|:||:::..||||.:||||.|||||||||:|||||:::.|||:||||||||||||||::|||||
plant  1147 AHKFISSIQQGYDTVVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDAL 1211

  Fly  1254 DAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLL-ANRGLYYTLYKLQSGA 1312
            |.....|||:.:||||||:.::|||.:.:||::.|.|.|:.|: .:.|:|.:|.:|...|
plant  1212 DRVIVNRTTVVVAHRLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMTA 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	488/1271 (38%)
		ABC_membrane	92..382	CDD:279056	92/290 (32%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	142/239 (59%)
		ABC_membrane	750..1020	CDD:279056	78/269 (29%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	121/240 (50%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	494/1289 (38%)
		ABC_membrane	50..303	CDD:279056	86/273 (32%)
		ABC_MTABC3_MDL1_MDL2	368..606	CDD:213216	142/239 (59%)
		ABC_membrane	709..978	CDD:279056	78/270 (29%)
		ABC_MTABC3_MDL1_MDL2	1027..1267	CDD:213216	121/239 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55496
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740