DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and PGP10

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_172538.1	Gene:	PGP10 / 837611	AraportID:	AT1G10680	Length:	1227	Species:	Arabidopsis thaliana

Alignment Length:	1244	Identity:	466/1244 - (37%)
Similarity:	688/1244 - (55%)	Gaps:	52/1244 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAI 135
            ||:.:||.:|...|..|..:|.:.|...|.:.|...:.||.|.| :|.|..|.....|:
plant    24 VSFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIFFGKLIN-IIGLAYLFPQEASH------ 81

  Fly   136 STLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN-Q 199
                  ||.::||...|:.:::|..|:|.:.|:.:....|...||..:.||:|.||:..:|.. .
plant    82 ------KVAKYSLDFVYLSVVILFSSWLEVACWMHTGERQAAKIRKAYLRSMLSQDISLFDTEIS 140

  Fly   200 SGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLV 264
            :|||.|.:..::..::|.::|||..|:|::..|:....:.|...||:|||.|:.:|...:|.|:.
plant   141 TGEVISAITSEILVVQDAISEKVGNFMHFISRFIAGFAIGFASVWQISLVTLSIVPFIALAGGIY 205

  Fly   265 AVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGI 329
            |..:|.|..:....|..|..:||..:..:|||:||.||.|.|::|:..:........|..:..|:
plant   206 AFVSSGLIVRVRKSYVKANEIAEEVIGNVRTVQAFTGEEKAVSSYQGALRNTYNYGRKAGLAKGL 270

  Fly   330 GFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAF 394
            |.|.|.|.::.|:||..|:...:|.||.       .:.|...|...:|::..:::|.|||.|..|
plant   271 GLGSLHFVLFLSWALLIWFTSIVVHKGI-------ANGGESFTTMLNVVIAGLSLGQAAPDISTF 328

  Fly   395 GIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRG 459
            ..|..|...:|.:||:    |..|..|:||......|.||:|.|.||:||:|.|.:|||..|..|
plant   329 MRASAAAYPIFQMIER----NTEDKTGRKLGNVNGDILFKDVTFTYPSRPDVVIFDKLNFVIPAG 389

  Fly   460 QTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIY 524
            :.|||||.||.||||.|.|::|||:|..|.::.:|.:::.||:.|||..||:|.|||:||||:|.
plant   390 KVVALVGGSGSGKSTMISLIERFYEPTDGAVMLDGNDIRYLDLKWLRGHIGLVNQEPVLFATTIR 454

  Fly   525 ENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPE 589
            |||.||::|||.|||..||..:.|..||..||:|::|.|||||.||||||||||:|:||::::|.
plant   455 ENIMYGKDDATSEEITNAAKLSEAISFINNLPEGFETQVGERGIQLSGGQKQRISISRAIVKNPS 519

  Fly   590 ILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQEL 654
            ||||||||||||..||..||.||::|..||||::|||||||||.||.|.|:..|:::|||:|.||
plant   520 ILLLDEATSALDAESEKIVQEALDRVMVGRTTVVVAHRLSTVRNADIIAVVGGGKIIESGSHDEL 584

  Fly   655 MELKD-HYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKK 718
            :...| .|.:|:..|      ...||..:...:..:..:...|:.:..........|......|:
plant   585 ISNPDGAYSSLLRIQ------EAASPNLNHTPSLPVSTKPLPELPITETTSSIHQSVNQPDTTKQ 643

  Fly   719 KKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYV 783
            .|..|.         .:..|.:|:|.....|.:.|.|.|..||:||:   .|.|.|.....|...
plant   644 AKVTVG---------RLYSMIRPDWKYGLCGTLGSFIAGSQMPLFAL---GIAQALVSYYMDWET 696

  Fly   784 RENS-NQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTG 847
            .:|. .:.|:.|....::..|...::...|||.|||||.|:|..||.|:||.|:.|||...|.:.
plant   697 TQNEVKRISILFCCGSVITVIVHTIEHTTFGIMGERLTLRVRQKMFSAILRNEIGWFDKVDNTSS 761

  Fly   848 SLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRT 912
            .|.:||..||..::.....|...:::::..:.....:|....|.|.||.||..|.|:.....::.
plant   762 MLASRLESDATLLRTIVVDRSTILLENLGLVVTAFIISFILNWRLTLVVLATYPLIISGHISEKI 826

  Fly   913 LMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVY 977
            .|.......:|.......||.|.:||||||.:...||.....|...|:...|.|.|.....|::|
plant   827 FMQGYGGNLSKAYLKANMLAGESISNIRTVVAFCAEEKVLDLYSKELLEPSERSFRRGQMAGILY 891

  Fly   978 GLARSLMFFAYAACMYYGTWCVIHRGI-LFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAK 1041
            |:::..:|.:|...::||: .::.:|: .|..|.|....||:....:...||.||::.||.....
plant   892 GVSQFFIFSSYGLALWYGS-ILMEKGLSSFESVMKTFMVLIVTALVMGEVLALAPDLLKGNQMVV 955

  Fly  1042 TIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGP 1106
            ::|..|.|:..:|...|  .:..:.||.:....|.||||:|.::.:.....|.|..|:.:||||.
plant   956 SVFELLDRRTQVVGDTG--EELSNVEGTIELKGVHFSYPSRPDVTIFSDFNLLVPSGKSMALVGQ 1018

  Fly  1107 SGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDN 1171
            ||.|||:.:.|:.||||...|..:||..|::.:.:.:||..:|:|.|||.||..||.|||.||
plant  1019 SGSGKSSVLSLVLRFYDPTAGIIMIDGQDIKKLKLKSLRRHIGLVQQEPALFATTIYENILYG-- 1081

  Fly  1172 ARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDE 1236
            ....::.|::.|.|.:|.|.||::||.||.|::||:|.|:||||:||||||||:::||:|:||||
plant  1082 KEGASESEVMEAAKLANAHSFISSLPEGYSTKVGERGIQMSGGQRQRIAIARAVLKNPEILLLDE 1146

  Fly  1237 ATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANR-G 1300
            ||||||.|||:|||.|||.....|||:.:||||||:.:||:|.|.::|.:.|.|.|..|:.|: |
plant  1147 ATSALDVESERVVQQALDRLMRDRTTVVVAHRLSTIKNSDMISVIQDGKIIEQGSHNILVENKNG 1211

  Fly  1301 LYYTLYKLQ 1309
            .|..|..||
plant  1212 PYSKLISLQ 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	464/1241 (37%)
		ABC_membrane	92..382	CDD:279056	83/290 (29%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	136/237 (57%)
		ABC_membrane	750..1020	CDD:279056	81/271 (30%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	115/239 (48%)
PGP10	NP_172538.1	PTZ00265	40..1221	CDD:240339	460/1228 (37%)
		ABC_membrane	50..313	CDD:279056	82/282 (29%)
		ABC_MTABC3_MDL1_MDL2	361..599	CDD:213216	136/237 (57%)
		ABC_membrane	666..935	CDD:279056	81/272 (30%)
		ABC_MTABC3_MDL1_MDL2	982..1220	CDD:213216	115/239 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	172	1.000	Domainoid score	I1139
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740