DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB2

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_194326.2	Gene:	ABCB2 / 828702	AraportID:	AT4G25960	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1291	Identity:	474/1291 - (36%)
Similarity:	709/1291 - (54%)	Gaps:	83/1291 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSL 107
            |.||.....:.....|::.:|     .:||..:||.:|...|..|..:|.:.|...|.:.|...:
plant    37 KLKKMQPSGDPAPEKEKEMTQ-----PKVSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFI 96

  Fly   108 IFGNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAA 172
            .||.|.| :|.|..|.....|:|            |.::||...|:.:.:|..|:|.:.|:.:..
plant    97 FFGKLIN-IIGLAYLFPKQASHR------------VAKYSLDFVYLSVAILFSSWLEVACWMHTG 148

  Fly   173 HSQILTIRSKFFRSILHQDMKWYDFNQS-GEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSL 236
            ..|...:|..:.||:|.||:..:|...| |||.|.:..|:..::|.|:|||..|:||:..|:...
plant   149 ERQAAKMRRAYLRSMLSQDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFIAGF 213

  Fly   237 VLAFVKGWQLSLVCLTSLPL--------TFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGI 293
            .:.|...||:|||.|:.:||        .|:|:||:|    |:.|.    |..|..:||..:..:
plant   214 AIGFTSVWQISLVTLSIVPLIALAGGIYAFVAIGLIA----RVRKS----YIKAGEIAEEVIGNV 270

  Fly   294 RTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYH 358
            |||:||.||.:.|..|:|.:........|..:..|:|.|.:...::.|:||..|:...:|.|
plant   271 RTVQAFTGEERAVRLYREALENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWFTSVVVHK--- 332

  Fly   359 EPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKK 423
                :..|.|...|...:|::..:::|.|||.|.||..||.|...:|.:||:..........|:|
plant   333 ----DIADGGKSFTTMLNVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRK 393

  Fly   424 LNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAG 488
            |.:....|:||:..|.||:||:|.|.::|||.|..|:.|||||.||.||||.|.|::|||:|.:|
plant   394 LGKVDGHIQFKDATFSYPSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISG 458

  Fly   489 NLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIK 553
            .:|.:|.|:.:|||.|||.:||:|.|||.||||:|.|||.||::|||.|||..||..:.|..||.
plant   459 AVLLDGNNISELDIKWLRGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFIN 523

  Fly   554 KLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAG 618
            .||:|::|.|||||.||||||||||||:||::::|.||||||||||||..||..||.||::|..|
plant   524 NLPEGFETQVGERGIQLSGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRVMVG 588

  Fly   619 RTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKD-HYFNLVTTQLGEDDGSVLSPTGD 682
            |||::|||||||||.||.|.|:::|::||.|.|:.|:...| .|.:|:.          |..|..
plant   589 RTTVVVAHRLSTVRNADIIAVVHEGKIVEFGNHENLISNPDGAYSSLLR----------LQETAS 643

  Fly   683 IYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKK-----KKKKVKDPNEVKPMLEV------- 735
            :.:|..:.       :.||  ....:..:.|.::.:     :::.|..|:...|..:|
plant   644 LQRNPSLN-------RTLS--RPHSIKYSRELSRTRSSFCSERESVTRPDGADPSKKVKVTVGRL 699

  Fly   736 MKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIV 800
            ..|.:|:|:....|.|.:.|.|..||:||:  |....::|........::...:.::.|..|.::
plant   700 YSMIRPDWMYGVCGTICAFIAGSQMPLFAL--GVSQALVSYYSGWDETQKEIKKIAILFCCASVI 762

  Fly   801 VGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATG 865
            ..|...::...||..|||||.|:|..||.|:|:.|:.|||:..|.:..|.:||..||..::....
plant   763 TLIVYTIEHICFGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKTIVV 827

  Fly   866 QRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTK 930
            .|...::|::..:.....::....|.|.||.||..|.::.....::..|........|.......
plant   828 DRSTILLQNLGLVVTSFIIAFILNWRLTLVVLATYPLVISGHISEKLFMQGYGGDLNKAYLKANM 892

  Fly   931 LAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYG 995
            ||.|.||||||||:...||...:.|...|:...:.|.|.....||.||:::..:|.:|...::||
plant   893 LAGESVSNIRTVAAFCAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIFSSYGLALWYG 957

  Fly   996 TWCVIHRGIL-FGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGV 1059
            : .::.:|:. |..|.|....||:...::...||.||::.||.....::|..|.|:..||..  .
plant   958 S-TLMDKGLAGFKSVMKTFMVLIVTALAMGETLALAPDLLKGNQMVASVFEILDRKTQIVGE--T 1019

  Fly  1060 SRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDV 1124
            |.:..:.||.:....|.||||:|.::.:.:..:|.|..|:.:||||.||.|||:.|.||.||||.
plant  1020 SEELNNVEGTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDP 1084

  Fly  1125 DEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNI 1189
            ..|..:|:..|::.:.:..||..:|:|.|||.||..||.|||.||:  ...:..|::.:...:|.
plant  1085 TAGKVMIEGKDIKKLDLKALRKHIGLVQQEPALFATTIYENILYGN--EGASQSEVVESAMLANA 1147

  Fly  1190 HEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALD 1254
            |.||.:||.||.|::||:|.|:||||:||||||||:::||.|:||||||||||.|||:|||.|||
plant  1148 HSFITSLPEGYSTKVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALD 1212

  Fly  1255 AASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANR-GLYYTLYKLQ 1309
            .....|||:.:||||||:.::|.|.|...|.:.|.|.|::|:.|: |.|:.|..||
plant  1213 RLMANRTTVVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLVLNKSGPYFKLISLQ 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	467/1262 (37%)
		ABC_membrane	92..382	CDD:279056	87/298 (29%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	138/237 (58%)
		ABC_membrane	750..1020	CDD:279056	77/270 (29%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	113/239 (47%)
ABCB2	NP_194326.2	PTZ00265	76..1269	CDD:240339	463/1247 (37%)
		ABC_membrane	86..349	CDD:279056	86/290 (30%)
		ABC_MTABC3_MDL1_MDL2	401..639	CDD:213216	138/247 (56%)
		ABC_membrane	714..983	CDD:279056	77/271 (28%)
		ABC_MTABC3_MDL1_MDL2	1030..1268	CDD:213216	113/239 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	172	1.000	Domainoid score	I1139
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740