DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB5

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_192092.1	Gene:	ABCB5 / 826974	AraportID:	AT4G01830	Length:	1230	Species:	Arabidopsis thaliana

Alignment Length:	1259	Identity:	491/1259 - (38%)
Similarity:	742/1259 - (58%)	Gaps:	52/1259 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRA 131
            :.|.|.:::||.::...|..|.::|.:.|:|.|:.:|..:|:||.|.:.|         |.:...
plant     9 NTKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGELIDAM---------GPNQNN 64

  Fly   132 DDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYD 196
            ::     ::::|.:..|...|:|:..|..::|.:.|:......|...|||.:.::||.||:.::|
plant    65 EE-----IVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGFFD 124

  Fly   197 FNQ-SGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIA 260
            ... :|||..||:.|...:.|.:.|||..|:..:..|||..|:||::||.|:||.|||:||..::
plant   125 VEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLTLVMLTSIPLLAMS 189

  Fly   261 MGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNM 325
            ...:|:..:|.:.:|...||.|:.|.|..|..||||.:|.||.:.:::|||.:..|...|:|:..
plant   190 GAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKELINLAYKSNVKQGF 254

  Fly   326 FSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPY 390
            .:|:|.|:::...:::|||..|:|..::::       :.|..|.:|.|..:|:..|:.:|.|:|.
plant   255 VTGLGLGVMFLVFFSTYALGTWFGGEMILR-------KGYTGGAVINVMVTVVSSSIALGQASPC 312

  Fly   391 IEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLK 455
            :.||...|.|..|:|..||:.|.|:..|..||.|.:....||.::|.|.||.||:..:....:|.
plant   313 LTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDIRGEIELRDVCFSYPARPKEEVFGGFSLL 377

  Fly   456 IHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFA 520
            |..|.|.||||.||.||||.|.|::|||||.:|.:|.:|.:||:..:.|:|.:||:|.|||:||:
plant   378 IPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRGKIGLVSQEPVLFS 442

  Fly   521 TSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALI 585
            :||.|||.||:|.||.|||:||:..||||.||.|||.|.:|||||.|.|||||||||||||||::
plant   443 SSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGTQLSGGQKQRIAIARAIL 507

  Fly   586 RDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGT 650
            :||.||||||||||||..||..||.||:::...|||:||||||||||.||.|.||::|::||.|:
plant   508 KDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRLSTVRNADIIAVIHRGKIVEEGS 572

  Fly   651 HQELMELKDH---YFNLVTTQ--------LGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDE 704
            |.||  ||||   |..|:..|        |...|||:.|  |....|...: :|::...||....
plant   573 HSEL--LKDHEGAYSQLLRLQEINKESKRLEISDGSISS--GSSRGNNSTR-QDDDSFSVLGLLA 632

  Fly   705 DEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGS 769
            .:|    ..|..::..:||.       ...:..:||||...:.:|.:...:.|...|||.:||..
plant   633 GQD----STKMSQELSQKVS-------FTRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFAK 686

  Fly   770 ILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 834
            :::......::  ::.:|..:|:.|::.|:...|......|.|.|||.||..|:|.:.||.::..
plant   687 VIEAFFKAPHE--LKRDSRFWSMIFVLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCFEKVVHM 749

  Fly   835 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAF 899
            ||.|||:..|.:|::.||||.|||.::...|..:...|:::::|..|:.::....|.:.::.|..
plant   750 EVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVI 814

  Fly   900 TPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVE 964
            .|||.|..|:|...|...:..:....|..:::|.:.|.:||||||...||...:.|.......::
plant   815 IPFIGINGYIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDTIK 879

  Fly   965 ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAF 1029
            ...:.....|:.:|::..:::..||:|.|.|...|......|.|||:|..||.:....|:.|.:|
plant   880 SGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTLTAVGISQASSF 944

  Fly  1030 APNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELA 1094
            ||:..||..||.:||..:.|...|..|........:.:|.:....:.|:|.||.::||.:.|.|:
plant   945 APDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLENVKGDIELCHISFTYQTRPDVQVFRDLCLS 1009

  Fly  1095 VSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFD 1159
            :..||.:||||.||.||||.|.|:|||||.|.|...:|..:::.:.:..||.|:|:|.|||:||:
plant  1010 IRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFN 1074

  Fly  1160 RTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARA 1224
            .|||.||:||......|:.|||:|.:.:|.|.||:::..||||.:||:|.|||||||||:|||||
plant  1075 DTIRANIAYGKGGEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVAIARA 1139

  Fly  1225 LIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEA 1289
            :::.|||:||||||||||||||:|||||||.....||||.:||||||:.::|||.|.:||::.|.
plant  1140 IVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEK 1204

  Fly  1290 GDHKQLL-ANRGLYYTLYKLQSGA 1312
            |.|:.|: ...|:|.:|.:|...|
plant  1205 GTHETLINIEGGVYASLVQLHINA 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	489/1251 (39%)
		ABC_membrane	92..382	CDD:279056	88/290 (30%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	141/239 (59%)
		ABC_membrane	750..1020	CDD:279056	76/269 (28%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	124/239 (52%)
ABCB5	NP_192092.1	PTZ00265	2..1224	CDD:240339	489/1253 (39%)
		ABC_membrane	35..293	CDD:279056	85/278 (31%)
		ABC_MTABC3_MDL1_MDL2	353..591	CDD:213216	141/239 (59%)
		ABC_membrane	667..936	CDD:279056	76/270 (28%)
		ABC_MTABC3_MDL1_MDL2	985..1224	CDD:213216	124/238 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55496
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740