Protein Alignment Mdr50 and ABCB3

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_192091.1
• Gene: ABCB3 / 826951
• AraportID: AT4G01820
• Length: 1229
• Species: Arabidopsis thaliana
• Alignment Length: 1266
• Identity: 488/1266 - (38%)
• Similarity: 744/1266 - (58%)
• Gaps: 60/1266 - (4%)

  Fly    66 EDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYR 130
            |..|.|.:::||.::...|..|.::|.:.|:..|:..|..:|:||    |:||..|..:|.|.
plant     3 EKTKTVPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFG----DLIDSIGQNQSNKD-- 61

  Fly   131 ADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWY 195
                    :::.|.:..|:..|:|:..|..::|.:.|:......|...|||.:.::||.||:.::
plant    62 --------IVEIVSKVCLKFVYLGLGTLGAAFLQVACWMITGERQAARIRSLYLKTILRQDIGFF 118

  Fly   196 DFNQS-GEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFI 259
            |...| |||..||:.|...:.:.:.|||..|:..:..|||..||||||||.|:||.|.|:||..|
plant   119 DVETSTGEVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGWLLTLVMLVSIPLLAI 183

  Fly   260 AMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRN 324
            |...:.:..:|.:.:|...||.|:.|.|..|..||||.:|.||.:.:.:|:|.:..|...::|:.
plant   184 AGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSYREFINLAYRASVKQG 248

  Fly   325 MFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAP 389
            ...|:|.|:::|..:.|||||.|:|..:::|       :.|..|.::.|..:|:..||::|...|
plant   249 FSMGLGLGVVFFVFFCSYALAIWFGGEMILK-------KGYTGGEVVNVMVTVVASSMSLGQTTP 306

  Fly   390 YIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNL 454
            .:.||...|.|..|:|..||:.|.|:..|..||.|.:....||.::|.|.||.||...:....:|
plant   307 CLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSYPARPMEEVFGGFSL 371

  Fly   455 KIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILF 519
            .|..|.|.||||.||.|||:.|.|::|||||.:|::|.:|.|||:..:.|:|.:||:|.|||:||
plant   372 LIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWIRGKIGLVSQEPVLF 436

  Fly   520 ATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARAL 584
            ::||.|||.||:|:||.|||:|||..||||.||.|||:|.:|||||.|.|||||||||||||||:
plant   437 SSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQLSGGQKQRIAIARAI 501

  Fly   585 IRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESG 649
            ::||.||||||||||||..||..||.||::|...|||:||||||||||.||.|.||::|::||.|
plant   502 LKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNADMIAVIHRGKIVEEG 566

  Fly   650 THQELMELKDH---YFNLVTTQLGEDDGSVLSPTGDI---------YKNFDIKDEDEEEIKVLSE 702
            :|.||  ||||   |..|:..|..:.:...|..:.::         .:|...:..|::.:.||.
plant   567 SHSEL--LKDHEGAYAQLIRLQKIKKEPKRLESSNELRDRSINRGSSRNIRTRVHDDDSVSVLG- 628

  Fly   703 DEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLF 767
                  ::..::|.:..:::.::.:    :..:..:||||...:.:|.:...:.|...|||.:||
plant   629 ------LLGRQENTEISREQSRNVS----ITRIAALNKPETTILILGTLLGAVNGTIFPIFGILF 683

  Fly   768 GSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAML 832
            ..:::......:|  ::.:|..:|:.|::.|:...|...:..|.|.:||.||.:|:|.:.||.::
plant   684 AKVIEAFFKPPHD--MKRDSRFWSMIFVLLGVASLIVYPMHTYLFAVAGGRLIQRIRVMCFEKVV 746

  Fly   833 RQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVAL 897
            ..||.||||..|.:|::.:|||.|||.::...|..:...|::.:....|:.::....|.|.::.|
plant   747 HMEVGWFDDPENSSGTIGSRLSADAALIKTLVGDSLSLSVKNAAAAVSGLIIAFTASWKLAVIIL 811

  Fly   898 AFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPA 962
            ...|.|.|..|:|...:......:....|..:::|.:.|.:||||||...||...:.|.......
plant   812 VMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKRCEDT 876

  Fly   963 VEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANAL 1027
            ::...:.....|:.:|::..:::..||:|.|.|...|......|.|||:|..||.|....|:.|.
plant   877 IKSGIKQGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTMTAIGISQAS 941

  Fly  1028 AFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDP-----WHSEGYVRFDKVKFSYPTRSEIQV 1087
            :|||:..|...||.:||..:..: |::|    |||.     .:.:|.:....:.|:|.||.::|:
plant   942 SFAPDSSKAKGAAASIFGIIDGK-SMID----SRDESGLVLENVKGDIELCHISFTYQTRPDVQI 1001

  Fly  1088 LKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVS 1152
            .:.|..|:..||.:||||.||.||||.|.|:|||||.|.|...:|..:::.:.:..:|.|:|:|.
plant  1002 FRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHITLDRVELKKLQLKWVRQQMGLVG 1066

  Fly  1153 QEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQ 1217
            |||:||:.|||.||:||......::.|||:|.:.:|.|.||:::..||||.:||:|.||||||||
plant  1067 QEPVLFNDTIRSNIAYGKGGDEASEAEIIAAAELANAHGFISSIQQGYDTVVGERGIQLSGGQKQ 1131

  Fly  1218 RIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFE 1282
            |:|||||:::.|||:||||||||||||||:|||||||.....|||:.:||||||:.::|||.|.:
plant  1132 RVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTVVVAHRLSTIKNADVIAVVK 1196

  Fly  1283 NGLVCEAGDHKQLL-ANRGLYYTLYKLQSGA 1312
            ||::.|.|.|:.|: ...|:|.:|.:|...|
plant  1197 NGVIVEKGTHETLINIEGGVYASLVQLHISA 1227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	485/1257 (39%)
ABCB3	NP_192091.1	PTZ00265	4..1223	CDD:240339	485/1259 (39%)