DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB20

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_191092.1	Gene:	ABCB20 / 824698	AraportID:	AT3G55320	Length:	1408	Species:	Arabidopsis thaliana

Alignment Length:	1390	Identity:	442/1390 - (31%)
Similarity:	694/1390 - (49%)	Gaps:	178/1390 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SDEE--DGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMID 118
            :|||  |..:.......|.:.|||..|.:.|..|.::|.::|.|.|...    :::.:....::|
plant    54 ADEEMDDQDELEPPPAAVPFSQLFACADRFDWVLMIVGSVAAAAHGTAL----IVYLHYFAKIVD 114

  Fly   119 LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKF 183
            :..........|::..     .|::.|.||...||...:.:..::.::|:......|...||||:
plant   115 VLAFSNDSSQQRSEHQ-----FDRLVQLSLTIVYIAGGVFISGWIEVSCWILTGERQTAVIRSKY 174

  Fly   184 FRSILHQDMKWYD-FNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLS 247
            .:.:|:|||.::| :..:|::.|::..|:..::..|:|||..::|.:..|:..||:.||..|:::
plant   175 VQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKVGNYIHNMATFISGLVIGFVNCWEIA 239

  Fly   248 LVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKER 312
            |:.|.:.|....|.|:..:...|||:.....||.||.:||.|:|.|||:.||..|.....:|...
plant   240 LITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAAGIAEQAISYIRTLYAFTNETLAKYSYATS 304

  Fly   313 VVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSV 377
            :.|.....|..::..|:|.|..:.....|.||..|.|...|..|       ..:.|.:|...|:|
plant   305 LQATLRYGILISLVQGLGLGFTYGLAICSCALQLWIGRFFVHNG-------RANGGEIIAALFAV 362

  Fly   378 MMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPT 442
            ::..:.:..||....:|...:.|..::|.:|.:...:  .:.||..|......|||:.|.|.|.:
plant   363 ILSGLGLNQAATNFYSFDQGRIAAYRLFEMITRSSSV--ANQEGAVLASVQGNIEFRNVYFSYLS 425

  Fly   443 RPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRS 507
            |||:.||:...|.:...:.|||||.:|.|||:.|.|::|||||..|.:|.:|.|:|:|.:.||||
plant   426 RPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERFYDPTLGEVLLDGENIKNLKLEWLRS 490

  Fly   508 RIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSG 572
            :||:|.|||.|.:.||.|||.||| |||.::||.||..|:|..||..|.|||:|.||..|..::.
plant   491 QIGLVTQEPALLSLSIRENIAYGR-DATLDQIEEAAKNAHAHTFISSLEKGYETQVGRAGLAMTE 554

  Fly   573 GQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRI 637
            .||.:::||||::.:|.||||||.|..||..:|..||.||:.:..||:|||:|.|||.::.||.|
plant   555 EQKIKLSIARAVLLNPTILLLDEVTGGLDFEAERIVQEALDLLMLGRSTIIIARRLSLIKNADYI 619

  Fly   638 VVINKGEVVESGTHQELMELKDHYFNLV----TTQLG----------------EDDGS------- 675
            .|:.:|::||.|||.||:.|...|..|:    .|:|.                |.|.|
plant   620 AVMEEGQLVEMGTHDELINLGGLYAELLKCEEATKLPRRMPVRNYKESAVFEVERDSSAGCGVQE 684

  Fly   676 ------VLSP-------------------------------TGDIYKNFD-------IKDEDEEE 696
                  :.||                               ||:...:.|       ||.:|..|
plant   685 PSSPKMIKSPSLQRGSGVFRPQELCFDTEESPKAHSPASEKTGEDGMSLDCADKEPTIKRQDSFE 749

  Fly   697 IKVL----------------SEDED--EDVMVTDEKNKKKK----KKKVKDPNEVK--------- 730
            :::.                ||.|.  ..::.:|.||::..    .:.:..|::.|
plant   750 MRLPHLPKVDVQCPQQKSNGSEPESPVSPLLTSDPKNERSHSQTFSRPLSSPDDTKANGKASKDA 814

  Fly   731 ------PMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQ 789
                  ....:.:::.||||...:|.:.:.|.|...|:.|.:...::... .|....::||..::
plant   815 QHKESPSFWRLAQLSFPEWLYAVLGSLGAAIFGSFNPLLAYVIALVVTEY-YKSKGGHLREEVDK 878

  Fly   790 YSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLS 854
            :.|.....|||..:|.|||.::|||.||::|||:|.:||.||||.||.||||:.|...:|..||:
plant   879 WCLIIACMGIVTVVANFLQHFYFGIMGEKMTERVRRMMFSAMLRNEVGWFDDEENSPDTLSMRLA 943

  Fly   855 GDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENM 919
            .||..|:.|...|:...:|....:.:.:.:.:...|.|.|||||..|.:.::...|:..:|..:.
plant   944 NDATFVRAAFSNRLSIFIQDSFAVIVALLIGLLLGWRLALVALATLPILTLSAIAQKLWLAGFSK 1008

  Fly   920 GSAKTMENCTKLAVEVVSNIRTVAS------------LGREEMFHQNYI-GMLIPAVEISKRNTH 971
            |..:.....:.:..:.|.||.||.:            :..:.:..|:|: ||.|
plant  1009 GIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVMELYRMQLQRILRQSYLHGMAI----------- 1062

  Fly   972 FRGLVYGLARSLMFFAYAACMYYGTWCV---IHRGILFGDVFKVSQALI------MGTASIANAL 1027
              |..:|.::.|:|    ||.....||.   ::||.:     |:|.|:.      ..|.::....
plant  1063 --GFAFGFSQFLLF----ACNALLLWCTALSVNRGYM-----KLSTAITEYMVFSFATFALVEPF 1116

  Fly  1028 AFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLE 1092
            ..||.:.|...:..::|..:.|.|:|......:..|.:..|.:....|.|.||||.||.||....
plant  1117 GLAPYILKRRKSLISVFEIVDRVPTIEPDDNSALKPPNVYGSIELKNVDFCYPTRPEILVLSNFS 1181

  Fly  1093 LAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPIL 1157
            |.:|.||.:|:||.||.||||.|.|::|:||...|..|:|..|::..::..||:.:|:|.||||:
plant  1182 LKISGGQTVAVVGVSGSGKSTIISLVERYYDPVAGQVLLDGRDLKLYNLRWLRSHMGLVQQEPII 1246

  Fly  1158 FDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIA 1222
            |..||||||.|.  ..|.::.|:..|.:.:|.|.||::||.||||.:|.:|.:|:.|||||||||
plant  1247 FSTTIRENIIYA--RHNASEAEMKEAARIANAHHFISSLPHGYDTHIGMRGVELTPGQKQRIAIA 1309

  Fly  1223 RALIRNPKIMLLDEATSALDAESEKVVQDALDAASEG-RTTISIAHRLSTVVHSDVIFVFENGLV 1286
            |.:::|..|:|:|||:|::::||.:|||:|||....| :|||.||||.:.:.|.|.|.|...|.:
plant  1310 RVVLKNAPIILIDEASSSIESESSRVVQEALDTLIMGNKTTILIAHRAAMMRHVDNIVVLNGGRI 1374

  Fly  1287 CEAGDHKQLLANRGLYYTLYKLQSG 1311
            .|.|.|..|.|..|||..|.:...|
plant  1375 VEEGTHDSLAAKNGLYVRLMQPHFG 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	437/1370 (32%)
		ABC_membrane	92..382	CDD:279056	75/290 (26%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	117/240 (49%)
		ABC_membrane	750..1020	CDD:279056	80/291 (27%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	111/239 (46%)
ABCB20	NP_191092.1	MdlB	86..651	CDD:224055	203/583 (35%)
		ABC_membrane	93..366	CDD:279056	75/288 (26%)
		P-loop_NTPase	414..648	CDD:304359	117/234 (50%)
		MdlB	821..1400	CDD:224055	207/604 (34%)
		ABC_membrane	841..1112	CDD:279056	81/293 (28%)
		P-loop_NTPase	1159..1395	CDD:304359	111/237 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	48	1.000	Domainoid score	I4479
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780