Protein Alignment Mdr50 and ABCB19

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_189528.1
• Gene: ABCB19 / 822519
• AraportID: AT3G28860
• Length: 1252
• Species: Arabidopsis thaliana
• Alignment Length: 1318
• Identity: 488/1318 - (37%)
• Similarity: 747/1318 - (56%)
• Gaps: 108/1318 - (8%)

  Fly    30 EDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLS 94
            |.:..|.|:......|||.                    :.:.:|:||.:|.|.|..|..:|.|.
plant     3 ETNTTDAKTVPAEAEKKKE--------------------QSLPFFKLFSFADKFDYLLMFVGSLG 47

  Fly    95 AVATGLTTPANSLIFGNLAN----DMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGI 155
            |:..|.:.|...|:||.:.|    :.:||..::.                 :|.::||...|:|:
plant    48 AIVHGSSMPVFFLLFGQMVNGFGKNQMDLHQMVH-----------------EVSRYSLYFVYLGL 95

  Fly   156 IMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFN-QSGEVASRMNEDLSKMEDGLA 219
            ::...||..|.|:.|:...|:..:|.|:..::|.||:.::|.: ::|::...::.|...::|.::
plant    96 VVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDAIS 160

  Fly   220 EKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAV 284
            |||..|:|||..|:..||:.||..|:|:|:.:..:|....|.||.|...:.:..|....||.|.|
plant   161 EKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANAGV 225

  Fly   285 VAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYG 349
            :||.|::.:|||.::.||:|.:.||.:.:.....|..|..|..|:|.|..:.....|:||.|||
plant   226 IAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFWY- 289

  Fly   350 VGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEI 414
            .|:.|:.      ...|.|...|..||.::|.|::|.:...:.||...|.|..|:..||.|.|.|
plant   290 AGVFIRN------GQTDGGKAFTAIFSAIVGGMSLGQSFSNLGAFSKGKAAGYKLMEIINQRPTI 348

  Fly   415 --NPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQ 477
              :|:|  ||.|::....||||:|.|.||:||:|.|....|:....|:|||:||.||.||||.:.
plant   349 IQDPLD--GKCLDQVHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSGKSTVVS 411

  Fly   478 LVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAA 542
            |::|||||.:|.:|.:|..:|.|.:.:||.:||:|.|||.||||:|.|||.||:.|||..|:|||
plant   412 LIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATMVEVEAA 476

  Fly   543 AAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAK 607
            |:||||..||..|||||||.|||||.|||||||||||||||:::||:||||||||||||.:||:.
plant   477 ASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALDASSESI 541

  Fly   608 VQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ--LG 670
            ||.||::|..||||::|||||.|:|..|.|.||.:|:|||:|||:||:.....|.:|:..|  :|
plant   542 VQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIRFQEMVG 606

  Fly   671 EDDGS-------------------VLSPTGDIYKN--FDIKDEDEEEIKVLSEDEDEDVMVTDEK 714
            ..|.|                   .||......:|  :......:..|:::|..|      ||.|
plant   607 TRDFSNPSTRRTRSTRLSHSLSTKSLSLRSGSLRNLSYSYSTGADGRIEMISNAE------TDRK 665

  Fly   715 NKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDN 779
            .:..:..          ...::|:|.|||....:|.:.|::.|...|.||::..:::::....|.
plant   666 TRAPENY----------FYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYTDY 720

  Fly   780 DQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKAN 844
            |...|: :.:|...::.||:....|..:|.|||.|.||.||.|:|.:|..|:||.||.|||:..:
plant   721 DSMERK-TKEYVFIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNEVGWFDEDEH 784

  Fly   845 GTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYM 909
            .:..:.|||:.|||.|:.|..:||..|:|::::|.....::...||.:.|:.|...|.:::|.:.
plant   785 NSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTFPLLVLANFA 849

  Fly   910 QRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFR- 973
            |:..:......:||.....:.:|.|.||||||||:...:    ...:.:....:.:.::.:.:|
plant   850 QQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQ----SKILSLFCHELRVPQKRSLYRS 910

  Fly   974 ---GLVYGLARSLMFFAYAACMYYGTWCVIHRGI-LFGDVFKVSQALIMGTASIANALAFAPNMQ 1034
               |.::||::..::.:.|..::||.. ::.:|: .|..|.||...|::...|:|..::.||.:.
plant   911 QTSGFLFGLSQLALYGSEALILWYGAH-LVSKGVSTFSKVIKVFVVLVITANSVAETVSLAPEII 974

  Fly  1035 KGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHS-EGYVRFDKVKFSYPTRSEIQVLKGLELAVSKG 1098
            :|..|..::|:.|.||..| |......||..: .|.:.|..|.|:||:|.::.|.:...|.:..|
plant   975 RGGEAVGSVFSVLDRQTRI-DPDDADADPVETIRGDIEFRHVDFAYPSRPDVMVFRDFNLRIRAG 1038

  Fly  1099 QKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIR 1163
            ...||||.||.|||:.|.:|:||||...|..:||..|:|.:::.:||.::|:|.|||.||..||.
plant  1039 HSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRRLNLKSLRLKIGLVQQEPALFAATIF 1103

  Fly  1164 ENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRN 1228
            :||:||.:  ..|:.|:|.|.:.:|.|.||:.||.||.|.:||:|.|||||||||||||||:::|
plant  1104 DNIAYGKD--GATESEVIDAARAANAHGFISGLPEGYKTPVGERGVQLSGGQKQRIAIARAVLKN 1166

  Fly  1229 PKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHK 1293
            |.::||||||||||||||.|:|:||:....||||:.:||||||:...|.|.|.::|.:.|.|.|.
plant  1167 PTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRGVDCIGVIQDGRIVEQGSHS 1231

  Fly  1294 QLLAN-RGLYYTLYKLQS 1310
            :|::. .|.|..|.:||:
plant  1232 ELVSRPEGAYSRLLQLQT 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	480/1275 (38%)
ABCB19	NP_189528.1	MdlB	26..604	CDD:440747	254/603 (42%)
		MdlB	666..1248	CDD:440747	214/600 (36%)