DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and abcb11a

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:XP_009303249.2 Gene:abcb11a / 797269 ZFINID:ZDB-GENE-050517-13 Length:1320 Species:Danio rerio


Alignment Length:1334 Identity:558/1334 - (41%)
Similarity:792/1334 - (59%) Gaps:85/1334 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 KKKSKHDESDAS---DEEDGSQYHEDVKQ------VSYFQLFRYATKKDRALYVIGLLSAVATGL 100
            |.||.:...|:.   :.||....:.:||:      |.:|||||::|.::..:.|:|...::..|.
Zfish     3 KNKSGNSPEDSEVIYNAEDADLKNGEVKKKEKAPTVGFFQLFRFSTWREVLMMVVGSFCSLVHGA 67

  Fly   101 TTPANSLIFGNLANDM----IDLGGLLESGKS--------------YRADDAISTLLLD---KVR 144
            .||...|::|.:.|..    :::..|.:..|:              .|.|:......:|   ::.
Zfish    68 ATPLMLLVYGMMTNTFVEYEVEILELTDPNKTCINNTISWMNGSAVQRPDNTTIYCGVDIEAEMT 132

  Fly   145 QFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNE 209
            .|:|....||:.:|:.|:..||.:..||..||..||..:||.|:..::.|:|.|..||:.:||::
Zfish   133 NFALYYIGIGVGVLILSFFQITFWVSAAARQIQRIRKTYFRKIMCMEIGWFDCNSVGELNTRMSD 197

  Fly   210 DLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKK 274
            |::|:.:.:|::|.:|:..:..|:...::.|:.||:|:||.:...||..:|.||:|:|.:||..:
Zfish   198 DINKINNAIADQVSIFIERISTFIFGFMVGFIGGWKLTLVVIAVSPLLGLAAGLMAMAVARLTGR 262

  Fly   275 EVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIY 339
            |:..||.|..||:..||.||||.||.||.||...|...:|.|:...||:.|..|:..|.||..|:
Zfish   263 ELKAYAKAGAVADEVLSSIRTVAAFGGEHKEAERYDRNLVQAQEWGIKKGMIIGVFQGYLWCIIF 327

  Fly   340 ASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKV 404
            ..||||||:|..|||:      .:....|.::.|||.|::|:||:|.|:|.:|||...:.|...:
Zfish   328 LCYALAFWFGSKLVIE------TQELTPGGLVQVFFGVLIGAMNLGQASPCLEAFASGRAAAKSI 386

  Fly   405 FHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSG 469
            |..|::.|||:....||..|::....|||..|.|.||:||||.||:.||:.:..|:|.|.|||||
Zfish   387 FDTIDREPEIDCFSDEGHTLDKVKGDIEFHSVNFNYPSRPEVKILDDLNIVVKAGETTAFVGPSG 451

  Fly   470 CGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDA 534
            .||:|.|||:||||||..|.:..:|.:::.|:|.||||.||||.|||:||||:|.|||||||...
Zfish   452 SGKTTTIQLIQRFYDPSEGMVSLDGHDIRSLNIQWLRSLIGVVEQEPVLFATTIAENIRYGRAGV 516

  Fly   535 TREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSA 599
            |.:||..||..|||..||..||:.:||||||.|.|:||||||||||||||:|:|.|||||.||||
Zfish   517 TMQEIIEAAKQANAYNFIMSLPQTFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSA 581

  Fly   600 LDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNL 664
            ||..|||.||.||:|...|||||.:||||||:|.||.||....|..||.|||.:|::.|..||.|
Zfish   582 LDNESEAVVQEALDKARQGRTTISIAHRLSTIRNADVIVGFEHGRAVERGTHSQLLDKKGVYFTL 646

  Fly   665 VTTQLGEDDGSVLSPTGDIYKNFDIKDEDE-EEIKVLSEDEDEDVM------------------- 709
            ||.|....|.....|.......  :.:|.| ||::..|....|.|:                   
Zfish   647 VTLQNQGKDTDTDKPENTAESR--VTEEAELEELRRFSSGSYESVLRRRSLSQLSNSLSVISGKF 709

  Fly   710 --------VTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVL 766
                    :.:..|.||.|.|.|:..:..|:..::|.|:|||..:.:|.|.:.|.|...|::|:|
Zfish   710 DFNSDLFEMEESDNNKKSKGKAKEDIKPAPVARILKYNRPEWPYMLLGSIGAAINGSLNPMYALL 774

  Fly   767 FGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAM 831
            |..||...|:.|.|.. |...|...:.|::.|:|...:.|||.|.|..:||.||.|||...|:||
Zfish   775 FSQILGTFSIPDPDDQ-RRQINGICILFVVIGVVSFFSQFLQGYSFAKSGELLTRRLRKFGFQAM 838

  Fly   832 LRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVA 896
            |:||:.||||..|..|:|..||:.:|:.||||||.:||.||.|::.:.....::.|:.|.|.||.
Zfish   839 LKQEIGWFDDPMNSPGALTTRLATNASMVQGATGSQIGMIVNSLTNIGASFIIAYYFSWKLSLVV 903

  Fly   897 LAFTPFILIAFYMQR---TLMAKENMGSAKT-MENCTKLAVEVVSNIRTVASLGREEMFHQNYIG 957
            ..|.|.|.::...|.   |.:|.|:    || :|...:::.|.:|||||:|.|.:|:.|...:..
Zfish   904 TCFLPLIGLSGVFQSKMLTGLANED----KTALEAAGQVSSEAMSNIRTIAGLAKEKHFVAQFEK 964

  Fly   958 MLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTAS 1022
            .|....:.:|:..:..|:.:..||.::|.||||...||.:.|.|.|:.:..||:|..||:....:
Zfish   965 QLQAPYKAAKKKAYVYGICFAFARCVIFMAYAASFRYGGYLVSHEGLQYMMVFRVISALVTSATA 1029

  Fly  1023 IANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSR---DPWHS-EGYVRFDKVKFSYPTRS 1083
            :..|.:|.|:..|...:|..:|..|.|.|.|    .||:   ..|:. :|.|.|...:|:||:|.
Zfish  1030 LGRASSFTPDYAKAKISAAQLFQLLDRVPKI----NVSKTEGQSWNDFKGKVEFKGCRFTYPSRP 1090

  Fly  1084 EIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQL 1148
            ::|||:||.::|..||.:|.||.|||||||.:||::||||.|||..|||.....::|:..||:|:
Zfish  1091 DVQVLRGLVVSVHPGQTLAFVGSSGCGKSTSVQLLERFYDPDEGQVLIDGRPSDSISVPFLRSQI 1155

  Fly  1149 GIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSG 1213
            |||||||:|||.:|.|||.||||:|.|:.:|||.|.||:.:|:|:..||..|:|::|.:|:|||.
Zfish  1156 GIVSQEPVLFDCSIAENIQYGDNSRTVSMEEIIDAAKKAYLHDFVMTLPDKYETQVGAQGSQLSR 1220

  Fly  1214 GQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVI 1278
            |||||||||||::|||||:||||||||||.||||.||.|||.|.:|||.|.|||||||:..:|:|
Zfish  1221 GQKQRIAIARAIVRNPKILLLDEATSALDTESEKTVQAALDEARQGRTCIVIAHRLSTIQSADII 1285

  Fly  1279 FVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            .|...|.|.|.|.|.:|:|.:..||.|  :.:||
Zfish  1286 AVMSQGEVIEKGTHDELMAKKAAYYKL--VTTGA 1317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 549/1301 (42%)
ABC_membrane 92..382 CDD:279056 101/310 (33%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 146/236 (62%)
ABC_membrane 750..1020 CDD:279056 101/273 (37%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 137/238 (58%)
abcb11aXP_009303249.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3024
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1057 1.000 Inparanoid score I248
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm25966
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1110.780

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