DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr50 and Abcb5

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_084237.1 Gene:Abcb5 / 77706 MGIID:1924956 Length:1255 Species:Mus musculus


Alignment Length:1269 Identity:515/1269 - (40%)
Similarity:748/1269 - (58%) Gaps:49/1269 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 EEDGSQY---HEDVKQVSY-----FQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLAN 114
            :|...:|   .|.|.:|..     .::||:|...|..|..:|:|:::..|.|.|..||:.|.:::
Mouse    11 QETNQRYGPLQEQVPKVGNQAVGPIEIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISD 75

  Fly   115 DMIDLGGLLESGKS-YRADDAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILT 178
            .:|: |.|:::.:: |:........|.:.:...:|....||...|:..|:.|:.:...|..|...
Mouse    76 HLIN-GCLVQTNRTKYQNCSQTQEKLNEDIIVLTLYYIGIGAAALIFGYVQISFWVITAARQTTR 139

  Fly   179 IRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKG 243
            ||.:||.|||.||:.|:|.:...|:.:||..|::|:.||:.:|:.:....:..|...||::.:|.
Mouse   140 IRKQFFHSILAQDISWFDGSDICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKS 204

  Fly   244 WQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAA 308
            |:||||.|::.||...:..|.:.....|..||:..|:.|..|||.|||.|:||.||..:.||:..
Mouse   205 WKLSLVVLSTSPLIMASSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQR 269

  Fly   309 YKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITV 373
            |.:.:..||...|||...|.:..|.::||:..:|.||||||..|:..|  ||   .|..||::.|
Mouse   270 YTQHLKDAKDAGIKRATASKLSLGAVYFFMNGAYGLAFWYGTSLIFGG--EP---GYTIGTILAV 329

  Fly   374 FFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEF 438
            ||||:..|..||..||::|.|.:|:||...:|.:|::.|.|:.....|.........||||.|.|
Mouse   330 FFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSF 394

  Fly   439 QYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDIN 503
            .||:||...:|..|||||..|:|||||||||.||||.:||:||.|||:.|.:..:..:::..::.
Mouse   395 SYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVR 459

  Fly   504 WLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGA 568
            ..|.:||||.|||:||.|:|..||::|||....:|:|.||..|||..||...||.::|||||:||
Mouse   460 HYREQIGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGA 524

  Fly   569 QLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRR 633
            |:||||||||||||||:|:|:||:||||||||||.||:.||.||||.|.|||||:|||||||:|.
Mouse   525 QMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRG 589

  Fly   634 ADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEE-EI 697
            ||.||.:..|.|||.|||.|||..:..|::|...|                   |||..||: |.
Mouse   590 ADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQ-------------------DIKKVDEQMES 635

  Fly   698 KV-----------LSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCI 751
            :.           |.:........||:..:....:|...| ||. :|::.|::|.||..:.:|.:
Mouse   636 RTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLP-EVS-LLKIFKLSKSEWPFVVLGTL 698

  Fly   752 SSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAG 816
            :|.:.|...|:|:::||.::.:...| |...:::::..||:..::.|||..:...:|..|:|.|.
Mouse   699 ASALNGSVHPVFSIIFGKLVTMFEDK-NKATLKQDAELYSMMLVVLGIVALVTYLMQGLFYGRAE 762

  Fly   817 ERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALG 881
            |.|..|||...|:|||.|::||:|||.|.||:|...|:.|.|.:|||...|:|.:.|.:|.::|.
Mouse   763 ENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLGIVTQDVSNMSLS 827

  Fly   882 IALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLG 946
            |.:|..|.|.:.|:.|:|.|.:.:...:|...||.......:.::...|:|.|.|.|||||.||.
Mouse   828 ILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAGKIATEAVENIRTVVSLT 892

  Fly   947 REEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFK 1011
            ||..|.|.|...|......:.:..|..|..|.::.:.:.||:||...:|.:.:....::...:|.
Mouse   893 RERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMMPEGMFI 957

  Fly  1012 VSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVK 1076
            |..|:..|..:|...|.:||...|..:.|..:|..|:.:|:|.........|...||.:.|.:|.
Mouse   958 VFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNKPTINSCSQSGEKPDTCEGNLEFREVS 1022

  Fly  1077 FSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSM 1141
            |.||.|.|:.||:.:.|::.||:.:|.||.||||||||:||:|||||..:|..|:|..||:.:::
Mouse  1023 FVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGVDVKELNV 1087

  Fly  1142 TNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGE 1206
            ..||:|..||||||:||:.:|.|||:||||:|.|..:||......:|||.||..||..|:|.:|.
Mouse  1088 QWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGL 1152

  Fly  1207 KGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLST 1271
            :|.|||||||||:||||||:|.|||:||||||||||.|||||||.|||.|..|:|.:.:||||||
Mouse  1153 RGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLST 1217

  Fly  1272 VVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305
            :.::|:|.|.:||.:.|.|.|::||.|...|:.|
Mouse  1218 IQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKL 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 511/1255 (41%)
ABC_membrane 92..382 CDD:279056 99/290 (34%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 140/236 (59%)
ABC_membrane 750..1020 CDD:279056 86/269 (32%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 130/236 (55%)
Abcb5NP_084237.1 PTZ00265 48..1250 CDD:240339 505/1229 (41%)
ABC_membrane 53..334 CDD:279056 98/286 (34%)
ABC_MTABC3_MDL1_MDL2 387..624 CDD:213216 140/236 (59%)
ABC_membrane 697..963 CDD:279056 86/266 (32%)
ABC_MTABC3_MDL1_MDL2 1017..1252 CDD:213216 130/235 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 206 1.000 Domainoid score I2901
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1050 1.000 Inparanoid score I261
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - otm42316
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.780

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