Protein Alignment Mdr50 and Abcb8

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_083296.2
• Gene: Abcb8 / 74610
• MGIID: 1351667
• Length: 717
• Species: Mus musculus
• Alignment Length: 614
• Identity: 215/614 - (35%)
• Similarity: 320/614 - (52%)
• Gaps: 80/614 - (13%)

  Fly    87 LYVIGLLSAVATGLTTPANSLIFGNLANDMID--LGGLLESGKSYRADDAISTLLLDKVRQFSLQ 149
            |..:|....:|.|..          |.|..|.  ||.|:|....|..|...|  .:.:.|:.|:|
Mouse   127 LLALGAAIVLALGAA----------LVNVQIPLLLGQLVEIVAKYTRDHMGS--FVSESRKLSVQ 179

  Fly   150 NTYIGIIMLVCSYLSITCFNY------AAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMN 208
                  ::|:.....:..|.|      ......:.:|...|.|:|.||:.::|..::|::.||:.
Mouse   180 ------LLLLYGVQGLLTFGYLVLLSHIGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLT 238

  Fly   209 EDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVAT----- 268
            .|:.:.:......:...:......:||||...:...:|:|:      |..:...|:.|.|
Mouse   239 TDVQEFKSSFKLVISQGLRSCTQVIGSLVSLSMLSPRLTLM------LAVVTPALMGVGTLMGSG 297

  Fly   269 ----SRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERV--VAAKILNIKRNM-- 325
                ||..::::   |.|..||:.||..:|||:||..|.:|...|:..:  ...|...:.|.:
Mouse   298 LRKLSRQCQEQI---ARATGVADEALGNVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIAL 359

  Fly   326 ---FSGIGFGLL---WFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNI 384
               .|.|.|..:   ..||..|..      .|..:||           |.:::  |.|...::..
Mouse   360 FQGLSNIAFNCMVLGTLFIGGSLV------AGQQLKG-----------GDLMS--FLVASQTVQR 405

  Fly   385 GMAAPYIEAFG-IAKG--ACAKVFHIIEQIPEINPIDGEGKKLNEPLT-TIEFKEVEFQYPTRPE 445
            .||:..: .|| :.:|  |.|:||..:...|.| |:.|.....|:.:. :|.|:.|.|.||.||.
Mouse   406 SMASLSV-LFGQVVRGLSAGARVFEYMALSPVI-PLTGGYCIPNKDIRGSITFQNVTFSYPCRPG 468

  Fly   446 VSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSR-I 509
            .::|....||:..|:.|||||.||.||:|...|::|||||:||::..:|.:|:.|:.:|||.: |
Mouse   469 FNVLKDFTLKLPSGKIVALVGQSGGGKTTVASLLERFYDPEAGSVTLDGHDLRTLNPSWLRGQVI 533

  Fly   510 GVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQ 574
            |.:.|||:||||:|.||||:|:.||:.||:..||..|||..||...|.||.|:|||||..|||||
Mouse   534 GFISQEPVLFATTIMENIRFGKLDASDEEVYTAAREANAHEFISSFPDGYSTVVGERGTTLSGGQ 598

  Fly   575 KQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVV 639
            |||:|||||||:.|.:|:|||||||||..||..||.||::.|||||.:::||||||||.|..|:|
Mouse   599 KQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRAAHSIIV 663

  Fly   640 INKGEVVESGTHQELMELKDHYFNLVTTQ 668
            :..|:|.|:|||:||::....|..|:..|
Mouse   664 MANGQVCEAGTHEELLKKGGLYSELIRRQ 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	215/614 (35%)
Abcb8	NP_083296.2	MdlB	116..696	CDD:440747	215/614 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	695..717