DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and TAP2

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_000535.3 Gene:TAP2 / 6891 HGNCID:44 Length:703 Species:Homo sapiens


Alignment Length:513 Identity:168/513 - (32%)
Similarity:267/513 - (52%) Gaps:34/513 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   167 CFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVA 231
            ||.|......|.||.:.|.|:|.||:.::...::||:.||::.|.:.|.:.|.....:.:..||.
Human   213 CFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVK 277

  Fly   232 FVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTV 296
            .||..........:|:|:.|..:|.|..|..:.......:.::.....|.|..|...|:.|::||
Human   278 VVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342

  Fly   297 KAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK--GYHE 359
            ::|..|..||..|||.:...:.|..:|::...         :|.........||.:::.  |..:
Human   343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERA---------LYLLVRRVLHLGVQMLMLSCGLQQ 398

  Fly   360 PAYENYDAGTMITVFFSVMMGSMNIG---MAAPYIEAFGIAK-GACAKVFHIIEQIPEINPIDGE 420
            ........|:::    |.|:...::|   ....||....::. ||..|||..:::.|.: |..| 
Human   399 MQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNL-PSPG- 457

  Fly   421 GKKLNEPLT---TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRF 482
               ...|.|   .::|::|.|.||.||:..:|..|...:..|:..|||||:|.||||...|:|..
Human   458 ---TLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNL 519

  Fly   483 YDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAAN 547
            |.|..|.:|.:...:...:..:|.|::..|||||:||:.|:..||.||.:....:::.|||.||:
Human   520 YQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAH 584

  Fly   548 AAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAAL 612
            |..||:::..|..|.|||:|:||:.|||||:||||||:|||.:|:|||||||||...|   ||..
Human   585 ADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE---QALQ 646

  Fly   613 EKVSAG-RTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQL 669
            :..|.| ||.:::||||..|:||.:|:|:.:|::.:..   :|.|.:|.|..||..:|
Human   647 DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRL 701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 168/513 (33%)
ABC_membrane 92..382 CDD:279056 51/216 (24%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 103/237 (43%)
ABC_membrane 750..1020 CDD:279056
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216
TAP2NP_000535.3 3a01208 1..697 CDD:273363 165/507 (33%)
Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196 301..389 22/96 (23%)
Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196 414..433 3/18 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 44 1.000 Domainoid score I12294
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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