DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Abcb9

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_071574.1 Gene:Abcb9 / 63886 RGDID:620254 Length:762 Species:Rattus norvegicus


Alignment Length:664 Identity:211/664 - (31%)
Similarity:324/664 - (48%) Gaps:97/664 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 DRKSFEPNKSKKKSKHDESDA-SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVAT 98
            |.::.||.   .:..|.|..| :::..|:...   |.:||       ||.|.|..|         
  Rat   143 DAEALEPG---NEGFHGEGGAPAEQASGATLQ---KLLSY-------TKPDVAFLV--------- 185

  Fly    99 GLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYI--------- 153
                         .|:..:.:..|.|:...|....||.::::.| :.||:.....:         
  Rat   186 -------------AASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSL 237

  Fly   154 ------GIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLS 212
                  ||..||.:.|:|            .:|:..|||::.|:..::|.|::|::.||:..|.:
  Rat   238 AAGIRGGIFTLVFARLNI------------RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 290

  Fly   213 KMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVT 277
            .:.|.:::.:.:|:...|...|.:|..|...||||||.....|:..:...:......||:|:..:
  Rat   291 MVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQS 355

  Fly   278 MYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKR---NMFSGIGFGLLWFFIY 339
            ..|.|:..||..:|.::||::|..|.:|...:..::.....||.|.   .|....|.||....:.
  Rat   356 ALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQ 420

  Fly   340 ASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAFGIAK--GAC 401
            .|   ..:||..|||.|       ...:|.:|. :.:..::|.....:.:.|   .|:.:  ||.
  Rat   421 VS---ILYYGGHLVISG-------QMSSGNLIAFIIYEFVLGDCMESVGSVY---SGLMQGVGAA 472

  Fly   402 AKVFHIIEQIP------EINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQ 460
            .|||..|::.|      .:.|...||:        ::|:.|.|.|.|||...:|..::..:..|:
  Rat   473 EKVFEFIDRQPTMVHDGRLAPDHLEGR--------VDFENVTFTYRTRPHTQVLQNVSFSLSPGK 529

  Fly   461 TVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYE 525
            ..|||||||.|||:|:.:::.||..|.|.:|.:|..:...|..:|...|.:|.|||:|||.||.:
  Rat   530 VTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPIGAYDHKYLHRVISLVSQEPVLFARSITD 594

  Fly   526 NIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEI 590
            ||.||......|.:..||..|||..||.:|..||.|..||:|||||||||||:|:||||:|:|.:
  Rat   595 NISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPV 659

  Fly   591 LLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELM 655
            |:|||||||||..||..:|.|:.......|.:|:|||||||.||..|||::||.||:.||||:|:
  Rat   660 LILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLL 724

  Fly   656 ELKDHYFNLVTTQL 669
            .....|..||..|:
  Rat   725 AQGGLYAKLVQRQM 738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 204/629 (32%)
ABC_membrane 92..382 CDD:279056 69/309 (22%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 114/236 (48%)
ABC_membrane 750..1020 CDD:279056
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216
Abcb9NP_071574.1 3a01208 44..734 CDD:273363 208/658 (32%)
ABC_membrane 189..451 CDD:279056 67/283 (24%)
ABCC_TAP 489..714 CDD:213215 107/232 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - LDO PTHR24221
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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