Protein Alignment Mdr50 and Abcb9

DIOPT Version :10

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_071574.1
• Gene: Abcb9 / 63886
• RGDID: 620254
• Length: 762
• Species: Rattus norvegicus
• Alignment Length: 664
• Identity: 211/664 - (31%)
• Similarity: 324/664 - (48%)
• Gaps: 97/664 - (14%)

  Fly    35 DRKSFEPNKSKKKSKHDESDA-SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVAT 98
            |.::.||.   .:..|.|..| :::..|:...   |.:||       ||.|.|..|
  Rat   143 DAEALEPG---NEGFHGEGGAPAEQASGATLQ---KLLSY-------TKPDVAFLV--------- 185

  Fly    99 GLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYI--------- 153
                         .|:..:.:..|.|:...|....||.::::.| :.||:.....:
  Rat   186 -------------AASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSL 237

  Fly   154 ------GIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLS 212
                  ||..||.:.|:|            .:|:..|||::.|:..::|.|::|::.||:..|.:
  Rat   238 AAGIRGGIFTLVFARLNI------------RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 290

  Fly   213 KMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVT 277
            .:.|.:::.:.:|:...|...|.:|..|...||||||.....|:..:...:......||:|:..:
  Rat   291 MVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQS 355

  Fly   278 MYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKR---NMFSGIGFGLLWFFIY 339
            ..|.|:..||..:|.::||::|..|.:|...:..::.....||.|.   .|....|.||....:.
  Rat   356 ALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQ 420

  Fly   340 ASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAFGIAK--GAC 401
            .|   ..:||..|||.|       ...:|.:|. :.:..::|.....:.:.|   .|:.:  ||.
  Rat   421 VS---ILYYGGHLVISG-------QMSSGNLIAFIIYEFVLGDCMESVGSVY---SGLMQGVGAA 472

  Fly   402 AKVFHIIEQIP------EINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQ 460
            .|||..|::.|      .:.|...||:        ::|:.|.|.|.|||...:|..::..:..|:
  Rat   473 EKVFEFIDRQPTMVHDGRLAPDHLEGR--------VDFENVTFTYRTRPHTQVLQNVSFSLSPGK 529

  Fly   461 TVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYE 525
            ..|||||||.|||:|:.:::.||..|.|.:|.:|..:...|..:|...|.:|.|||:|||.||.:
  Rat   530 VTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPIGAYDHKYLHRVISLVSQEPVLFARSITD 594

  Fly   526 NIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEI 590
            ||.||......|.:..||..|||..||.:|..||.|..||:|||||||||||:|:||||:|:|.:
  Rat   595 NISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPV 659

  Fly   591 LLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELM 655
            |:|||||||||..||..:|.|:.......|.:|:|||||||.||..|||::||.||:.||||:|:
  Rat   660 LILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLL 724

  Fly   656 ELKDHYFNLVTTQL 669
            .....|..||..|:
  Rat   725 AQGGLYAKLVQRQM 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	204/629 (32%)
Abcb9	NP_071574.1	3a01208	44..734	CDD:273363	208/658 (32%)