DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and abcb11b

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	XP_003199513.2	Gene:	abcb11b / 571189	ZFINID:	ZDB-GENE-050517-14	Length:	1348	Species:	Danio rerio

Alignment Length:	1347	Identity:	550/1347 - (40%)
Similarity:	786/1347 - (58%)	Gaps:	103/1347 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAV 96
            |.:|.||       ||||.:||              ..:|.:|||||:|:.::..:.|.|.|.|:
Zfish    36 SGKDNKS-------KKSKKEES--------------AIRVGFFQLFRFASCREIWMMVFGSLCAI 79

  Fly    97 ATGLTTPANSLIFGNLANDMID----LGGLLESGKS-------YRADDAISTLLLDKVR------ 144
            |.|...|...|:||.|.:..||    |..|.:..|:       :|.......|.|:..|
Zfish    80 AHGSAQPLMLLVFGMLTDTFIDYDIELNELSDPQKACVNNTIQWRNLTQEENLALNMTRSCGLLD 144

  Fly   145 -QFSLQN---TYIGI--IMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEV 203
             ::.:.|   .|:||  .:.:..||.|:.:..||..||..||..:||.::..::.|:|....||:
Zfish   145 IEYEMTNFAYYYVGIGAGVFILGYLQISLWITAAARQIQIIRKMYFRKVMRMEIGWFDCTSVGEL 209

  Fly   204 ASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVAT 268
            .:||::|::|:.|.:|::|.:|:.....||...::.|.:||:|:||.::..||..|..||:|:..
Zfish   210 NTRMSDDINKINDAIADQVGIFIQRFTTFVCGFLMGFARGWKLTLVIISVSPLIGIGAGLMALFV 274

  Fly   269 SRLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGL 333
            ::|...|:..||.|..||:..||.:|||.||.||.|||..|...:::|:...|::.:..|...|.
Zfish   275 AKLTGMELQAYAKAGAVADEVLSSVRTVAAFGGEKKEVDRYDRNLISAQQWGIRKGLIMGFFTGY 339

  Fly   334 LWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAK 398
            :||.|:..||||||||..||:.      .:.|..||::.|||.|::.::|:|.|:|.:|||...:
Zfish   340 MWFIIFLCYALAFWYGSSLVVD------TQEYSPGTLLQVFFGVLIAALNLGQASPCLEAFAAGR 398

  Fly   399 GACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVA 463
            ||...:|..|::.|||:.:...|.||::....:||..:.|.||:||||.||::|||::..|:|.|
Zfish   399 GAATIIFETIDREPEIDCLSEAGYKLDKVKGDLEFHNITFHYPSRPEVKILDQLNLQVKSGETTA 463

  Fly   464 LVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIR 528
            .|||||.||||.|||:||||||:.|.|..:|.:::.|:|.||||.||:|.|||:||||:|.||||
Zfish   464 FVGPSGAGKSTAIQLIQRFYDPKEGMLTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENIR 528

  Fly   529 YGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLL 593
            |||...:.::|..||..|||..||..||:.::|||||.|.|:||||||||||||||:|:|.||||
Zfish   529 YGRPGVSNDDIITAAKEANAYNFIMDLPQKFETLVGEGGGQMSGGQKQRIAIARALVRNPRILLL 593

  Fly   594 DEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELK 658
            |.||||||..|||.||.||:||..|||||.:||||||::.||.||....|..||.|.|.||:|.|
Zfish   594 DMATSALDNESEAVVQEALDKVRMGRTTISIAHRLSTIKNADVIVGFEHGRAVERGKHDELLERK 658

  Fly   659 DHYFNLVTTQLGEDDGSVLSPTGDIYKNFDIKDED------------------------------ 693
            ..||.|||.| .:.|.::........:..:..|.|
Zfish   659 GVYFTLVTLQ-SQGDKALNQKAQQEMEEAECCDSDAERRSLNRAGSYRASLRASIHQRSRSQLSN 722

  Fly   694 ---EEEIKVLSE----DEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCI 751
               |..:.:..|    ...|..:..:...|....:...:..|..|:..::|.|.|||..:..|.|
Zfish   723 AVPESSVAIAGELGPRSYSETTVPQEFMGKSGVPEDTAEEVEPAPVARILKYNAPEWPYMFFGSI 787

  Fly   752 SSVIMGCAMPIFAVLFGSILQILSVKDNDQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAG 816
            .:.:.|...|::::||..||...|:.|..:..|| .|...|:|::.|:|......||.|.|..:|
Zfish   788 GAAVNGGVNPVYSLLFSQILATFSMPDPVEQRRE-INGICLFFVVVGLVSFFTQMLQGYAFSKSG 851

  Fly   817 ERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALG 881
            |.||.|||.|.|:|||.||:.||||:.|..|:|..||:.||:.||||||.:||.||.|::.:.:.
Zfish   852 ELLTRRLRRLGFQAMLGQEIGWFDDRKNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVA 916

  Fly   882 IALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAK----TMENCTKLAVEVVSNIRTV 942
            :.:|.|:.|.|.||.|.|.||:.::...|    ||...|.||    .||...:::.|.::||||:
Zfish   917 VIISFYFSWKLTLVILCFLPFLALSGGFQ----AKMLTGFAKQDKEAMETAGQISGEALNNIRTI 977

  Fly   943 ASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFG 1007
            |.||:|..|.:.:...|....:.:.:..:..|..||.|:.::|.|.:|...:|.:.|.|.|:.|.
Zfish   978 AGLGKERNFVEMFETQLEAPYQAALKKANVYGACYGFAQCVVFMANSASYRFGGYLVYHEGLHFS 1042

  Fly  1008 DVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQP--SIVDRPGVSRDPWHSEGYV 1070
            .||:|..|::....::..|.::.|:..|...:|...|..|.|.|  |:..:.|...|  :.:|.:
Zfish  1043 FVFRVISAIVTSGTALGRASSYTPDYAKAKISAARFFQLLDRIPKISVYSKDGQKWD--NFKGDI 1105

  Fly  1071 RFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECD 1135
            .|...||:||:|.:||||.||.::|..||.:|.||.|||||||.:||::||||.:.|..|||..:
Zfish  1106 EFIDCKFTYPSRPDIQVLNGLNVSVKPGQTLAFVGSSGCGKSTSVQLLERFYDPNSGRVLIDGRE 1170

  Fly  1136 VRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGY 1200
            ...:::..||:::|||||||||||.:|.|||.||||.|.::..::|||.||:.:|:|:.:||..|
Zfish  1171 SSQINVAYLRSKIGIVSQEPILFDCSIAENIRYGDNQRELSMNDVISAAKKAQLHDFVMSLPEKY 1235

  Fly  1201 DTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISI 1265
            ||.:|.:|:|||.|||||||||||:||:|||:||||||||||.||||.||:|||.|.||||.|.|
Zfish  1236 DTNVGSQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQEALDKAREGRTCIVI 1300

  Fly  1266 AHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312
            ||||||:.:||:|.|...|.|.|.|.|..|:..:|.||.|  :.:||
Zfish  1301 AHRLSTIQNSDIIAVMSRGYVIEKGTHDYLMGLKGAYYKL--VTTGA 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	538/1304 (41%)
		ABC_membrane	92..382	CDD:279056	103/312 (33%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	144/236 (61%)
		ABC_membrane	750..1020	CDD:279056	101/273 (37%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	136/238 (57%)
abcb11b	XP_003199513.2	ABC_membrane	76..382	CDD:279056	103/311 (33%)
		PTZ00265	157..1339	CDD:240339	507/1195 (42%)
		ABC_MTABC3_MDL1_MDL2	432..668	CDD:213216	144/235 (61%)
		ABC_membrane	787..1053	CDD:279056	101/270 (37%)
		ABC_MTABC3_MDL1_MDL2	1105..1344	CDD:213216	136/240 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	198	1.000	Domainoid score	I3024
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1057	1.000	Inparanoid score	I248
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm25966
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.910