DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and Abcb9

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	664	Identity:	211/664 - (31%)
Similarity:	324/664 - (48%)	Gaps:	97/664 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DRKSFEPNKSKKKSKHDESDA-SDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVAT 98
            |.::.||.   .:..|.|..| :::..|:...   |.:||       ||.|.|..|
Mouse   143 DAEALEPG---NEGFHGEGGAPAEQASGATLQ---KLLSY-------TKPDVAFLV--------- 185

  Fly    99 GLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLLLDK-VRQFSLQNTYI--------- 153
                         .|:..:.:..|.|:...|....||.::::.| :.||:.....:
Mouse   186 -------------AASFFLIVAALGETFLPYYTGRAIDSIVIQKSMDQFTTAVVVVCLLAIGSSL 237

  Fly   154 ------GIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLS 212
                  ||..||.:.|:|            .:|:..|||::.|:..::|.|::|::.||:..|.:
Mouse   238 AAGIRGGIFTLVFARLNI------------RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 290

  Fly   213 KMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVT 277
            .:.|.:::.:.:|:...|...|.:|..|...||||||.....|:..:...:......||:|:..:
Mouse   291 MVSDLVSQNINIFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQS 355

  Fly   278 MYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKR---NMFSGIGFGLLWFFIY 339
            ..|.|:..||..:|.::||::|..|.:|...:..::.....||.|.   .|....|.||....:.
Mouse   356 ALARASTTAEETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQ 420

  Fly   340 ASYALAFWYGVGLVIKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAFGIAK--GAC 401
            .|   ..:||..|||.|       ...:|.:|. :.:..::|.....:.:.|   .|:.:  ||.
Mouse   421 VS---ILYYGGHLVISG-------QMSSGNLIAFIIYEFVLGDCMESVGSVY---SGLMQGVGAA 472

  Fly   402 AKVFHIIEQIP------EINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQ 460
            .|||..|::.|      .:.|...||:        ::|:.|.|.|.|||...:|..::..:..|:
Mouse   473 EKVFEFIDRQPTMVHDGSLAPDHLEGR--------VDFENVTFTYRTRPHTQVLQNVSFSLSPGK 529

  Fly   461 TVALVGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYE 525
            ..|||||||.|||:|:.:::.||..|.|.:|.:|..:...|..:|...|.:|.|||:|||.||.:
Mouse   530 VTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPIGAYDHKYLHRVISLVSQEPVLFARSITD 594

  Fly   526 NIRYGREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEI 590
            ||.||......|.:..||..|||..||.:|..||.|..||:|||||||||||:|:||||:|:|.:
Mouse   595 NISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPV 659

  Fly   591 LLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELM 655
            |:|||||||||..||..:|.|:.......|.:|:|||||||.||..|||::||.||:.||||:|:
Mouse   660 LILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLL 724

  Fly   656 ELKDHYFNLVTTQL 669
            .....|..||..|:
Mouse   725 AQGGLYAKLVQRQM 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	204/629 (32%)
		ABC_membrane	92..382	CDD:279056	69/309 (22%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	114/236 (48%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	208/658 (32%)
		ABC_membrane	189..451	CDD:279056	67/283 (24%)
		ABCC_TAP	489..714	CDD:213215	107/232 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12044
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	LDO	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910