Protein Alignment Mdr50 and Abcb10

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: NP_062425.1
• Gene: Abcb10 / 56199
• MGIID: 1860508
• Length: 715
• Species: Mus musculus
• Alignment Length: 615
• Identity: 213/615 - (34%)
• Similarity: 333/615 - (54%)
• Gaps: 32/615 - (5%)

  Fly   710 VTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVG--CISSVIMGCAMPIFAVLFGSILQ 772
            |.|..|..:::......:||..:|.:::..:.. |..|||  .:||||...| |.|   .|.|:.
Mouse   103 VRDLGNDSQRRPAATGRSEVWKLLGLVRPERGR-LSAAVGFLAVSSVITMSA-PFF---LGRIID 162

  Fly   773 ILSVKDNDQY---VRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQ 834
            ::....::.|   :.......:..||......||    ::|....:|:.:..|||..:|.::|||
Mouse   163 VIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGI----RVYLMQSSGQSIVNRLRTSLFSSILRQ 223

  Fly   835 EVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAF 899
            |||:||  ...||.|..|||.|.|.:..:..:.:...:::.:..::|:.:..:...||....|:.
Mouse   224 EVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSV 286

  Fly   900 TPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVE 964
            .|.|.:...:....:.|.:..:..::...|:||.|.:.||||:.:.|:|....:.|.|.:...::
Mouse   287 VPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQ 351

  Fly   965 ISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGD----VFKVSQALIMG---TAS 1022
            ::::....|...:|.|.........:.:|.|       |:|.|.    |.::|..|:..   ..|
Mouse   352 LAQKEALARAGFFGAAGLSGNLIVLSVLYKG-------GLLMGSAHMTVGELSSFLMYAFWVGLS 409

  Fly  1023 IANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQV 1087
            |....:|...:.||:.|...::..|.|||.:....|:..|....:|.:.|..|.|:||.|.|:.|
Mouse   410 IGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSV 474

  Fly  1088 LKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVS 1152
            .:...|::..|...|||||||.||||.:.|:.|.||.:.|...:|..|:|.::...||:::|.||
Mouse   475 FQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVS 539

  Fly  1153 QEPILFDRTIRENISYG-DNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQK 1216
            |||:||..::.|||:|| ||..:||.|::..|.:.:|..|||.:.|.|:||.:||||..||||||
Mouse   540 QEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQK 604

  Fly  1217 QRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVF 1281
            |||||||||::||||:||||||||||||:|.:||:|||...||||.:.|||||||:.:::.:.|.
Mouse   605 QRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVL 669

  Fly  1282 ENGLVCEAGDHKQLLAN-RGLYYTLYKLQS 1310
            ::|.:||.|.|::||.. .|||..|...||
Mouse   670 DHGKICEHGTHEELLLKPNGLYRKLMNKQS 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	211/611 (35%)
		ABC_membrane	92..382	CDD:279056
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216
		ABC_membrane	750..1020	CDD:279056	66/279 (24%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	122/240 (51%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	210/608 (35%)
		ABC_membrane	142..403	CDD:279056	66/277 (24%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	122/239 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810