DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr50 and abcb8

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001017544.1	Gene:	abcb8 / 548340	ZFINID:	ZDB-GENE-050410-6	Length:	714	Species:	Danio rerio

Alignment Length:	642	Identity:	213/642 - (33%)
Similarity:	331/642 - (51%)	Gaps:	59/642 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SKHDESDASDEED--GSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLS--AVATGLTTPANSLI 108
            |.|.|:|.::.:.  ..|..|.:.:.|:..|:.:...:..||....||:  |.|..:..|   |:
Zfish   105 SAHCEADVNNNKVPLEVQVKEKIPEFSWAVLWEFVRPQLFALMGAILLAFGAAALNIQIP---LM 166

  Fly   109 FGNLANDMIDLGGLLESGKSYRAD---DAISTLLLDKVRQFSLQNTYIGIIMLVCSYLSITCFNY 170
            .|:|.|  :....:.|....|..|   .|:..|.|     ::||.      :|...|  |...:.
Zfish   167 LGDLVN--VVARHMREQAGHYMRDIQAPAVKLLGL-----YALQG------LLTSGY--IILLSR 216

  Fly   171 AAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGS 235
            ........:|:..|.|:|.||:.::|.|::|::.:|:..|:.:.:......:...:......||.
Zfish   217 VGERVAADMRTTLFTSLLRQDIAFFDANKTGQLVNRLTSDIQEFKSSFKLVISQGLRSATQTVGC 281

  Fly   236 LVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGALSGIRTVKAFE 300
            .|..:....:|:.:.:..||....|..|:.....:|::|.....|.|..||:.||..:|||:||.
Zfish   282 FVSLYFISPKLTGLTVVVLPCLVGAGALIGSFLRKLSRKAQEQVAKATGVADEALGNVRTVRAFA 346

  Fly   301 GEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENY 365
            .|.:|:..|...|..:..:|      ..:|.|:..|...::..|. ...:|.:..|....|.::.
Zfish   347 MEDRELEMYAAEVQKSAAMN------ETLGTGIAVFQGLSNIVLN-CIVLGTIFAGGSLMARDDL 404

  Fly   366 DAGTMITVF------------FSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPID 418
            ..|.:::..            .|::.|.|..||:|.            |:||..:...|.: |:.
Zfish   405 SPGDLMSFLVASQTVQRSLASISILFGQMVRGMSAG------------ARVFEYLALDPSV-PLT 456

  Fly   419 GEGK-KLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRF 482
            |.|: .|:..:..::|..:.|.|||||...||...:|.:...:|||:||.||.||||...|::||
Zfish   457 GGGRIPLDSLMGRVDFMNISFSYPTRPGNQILKHFSLTLPPCKTVAIVGESGGGKSTVAALLERF 521

  Fly   483 YDPQAGNLLFNGTNLKDLDINWLRSR-IGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAA 546
            |||.:|.::.:|.:::.||.:|||.. ||.:.|||:||.||:.||||:|:..||..|:.:||..|
Zfish   522 YDPSSGVVMLDGLDIRTLDPSWLRGHVIGFISQEPVLFGTSVMENIRFGKPSATDAEVVSAAKQA 586

  Fly   547 NAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAA 611
            ||..||.....||:|:|||||..|||||||||||||||:::|.||:|||||||||..||..||.|
Zfish   587 NAHNFITGFADGYNTVVGERGVTLSGGQKQRIAIARALVKNPSILILDEATSALDAESERVVQEA 651

  Fly   612 LEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQ 668
            |::.:.|||.:|:||||||::.||.|.|::.|.:||:|||.||:.....|..|:..|
Zfish   652 LDRATTGRTVLIIAHRLSTIQAADLICVMSNGRIVEAGTHLELLSKGGLYAELIKRQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	207/619 (33%)
		ABC_membrane	92..382	CDD:279056	67/306 (22%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	123/237 (52%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
abcb8	NP_001017544.1	ABC_6TM_ABCB8_like	149..443	CDD:350018	72/330 (22%)
		TM helix 1	149..172	CDD:350018	8/25 (32%)
		TM helix 2	187..236	CDD:350018	13/61 (21%)
		TM helix 3	243..288	CDD:350018	7/44 (16%)
		TM helix 4	289..338	CDD:350018	13/48 (27%)
		TM helix 5	350..396	CDD:350018	9/52 (17%)
		TM helix 6	409..442	CDD:350018	6/44 (14%)
		ABC_MTABC3_MDL1_MDL2	470..708	CDD:213216	123/237 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810