DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr50 and Hmt-1

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_650503.1	Gene:	Hmt-1 / 41925	FlyBaseID:	FBgn0038376	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	747	Identity:	211/747 - (28%)
Similarity:	324/747 - (43%)	Gaps:	200/747 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 HEDVKQVSYFQLFRYATKKDR--------------ALYVIGLLSAVATGLTTPANSLIFGNLAND 115
            |||       ..|...|.||:              .::|:||   .|.|:..|.|.  ...|.||
  Fly   158 HED-------WWFHLKTNKDQIEMGLFVTRFLCSLLIFVLGL---KAPGIMAPYNP--HQRLDND 210

  Fly   116 MI-DLGGLLESGKSYRADDAISTLLLDKVRQ-----FSLQNTYIGIIMLVC-------------- 160
            .. :..|.:::|.::|..       ..|:|.     :..:|..:.|.::||
  Fly   211 TANESQGNVQTGSAFRNG-------WRKLRTVFPYLWPKKNIALQIAVIVCIILLLAGRVIKLFL 268

  Fly   161 -----------------------------SYL------SITCFN------YAAHSQILT--IRSK 182
                                         |:|      |:..||      :....|..|  |..:
  Fly   269 PIYRKKLVDSLTIAPIVFRWDFVLIYVALSFLQGGGTGSMGLFNNLRTFLWIRVQQYTTREIEIE 333

  Fly   183 FFRSILHQDMKWYDFNQSGE---VASRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGW 244
            .||.:....::|:...::||   |..|..:.::.:.:.:...:...:..|:..|...|.||  .|
  Fly   334 LFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAF--NW 396

  Fly   245 QLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEG--------ALSGIRTVKAFEG 301
            ...|:       .|:.|.|...:|..:.:.. |.|.....:|:.        :|....|||.:..
  Fly   397 WFGLI-------VFLTMFLYIASTIAITEWR-TKYQRRMNLADNEQRARSVDSLLNFETVKYYGA 453

  Fly   302 EAKEVAAYKERV-----------VAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK 355
            |..||..|:|.:           :...:||..:|:.  :..|||
  Fly   454 EHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNII--LCLGLL--------------------- 495

  Fly   356 GYHEPAYENYDAGTMITVFFSVMMGSMNIG---MAAPY-------IEAFGIAKGACAK------- 403
                       ||:::.|:..|...::.:|   :.:.|       :..||....|..|
  Fly   496 -----------AGSLLCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWFGTYYRAIQKNFVDMEN 549

  Fly   404 VFHIIEQIPEINPIDGEGKKLNEPLTT----IEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVAL 464
            :|.::::..||  :|..|   ..||.|    |||..|.|.|  .||..:|..::..:..|:|||:
  Fly   550 MFDLLKEEEEI--VDAPG---CSPLLTAGGGIEFSNVTFGY--SPEKIVLRNVSFTVPAGKTVAI 607

  Fly   465 VGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRY 529
            |||||.||||.::|:.||||.|.|.:|.:|.|:|.:....||..||||.|:.:||..:|:.||.|
  Fly   608 VGPSGAGKSTIMRLLFRFYDVQTGAILIDGQNIKLVQQQSLRKAIGVVPQDTVLFNNTIFYNIEY 672

  Fly   530 GREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLD 594
            .:..|:.|.:..||.||:....|...|:.|:|.|||||.:||||:|||:||||.|::.|.|:|||
  Fly   673 AKLGASDEAVYEAARAADIHERILGFPEKYETKVGERGLRLSGGEKQRVAIARTLLKAPIIVLLD 737

  Fly   595 EATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKD 659
            ||||||||.:|..:||||.:|.|.||||||||||||:..||.|:|:.:|.:.|.|.|:||:..:|
  Fly   738 EATSALDTHTERNIQAALARVCANRTTIIVAHRLSTIIHADEILVLQQGSIAERGRHEELVLRED 802

  Fly   660 H-YFNLVTTQL---------GEDDGSVLSPTG 681
            . |.::...||         |.|:|...:.:|
  Fly   803 GIYADMWQQQLKNLDAEQSGGSDNGDASAESG 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	208/743 (28%)
		ABC_membrane	92..382	CDD:279056	65/374 (17%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	117/237 (49%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
Hmt-1	NP_650503.1	MTABC_N	3..241	CDD:292803	22/101 (22%)
		ABC_membrane	255..530	CDD:279056	50/318 (16%)
		ATM1	314..811	CDD:227590	174/547 (32%)
		ABCC_ATM1_transporter	576..812	CDD:213220	117/237 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010