Protein Alignment Mdr50 and abcb5

DIOPT Version :9

• Sequence 1: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Sequence 2: XP_031759158.1
• Gene: abcb5 / 394865
• XenbaseID: XB-GENE-5950198
• Length: 1317
• Species: Xenopus tropicalis
• Alignment Length: 1309
• Identity: 545/1309 - (41%)
• Similarity: 788/1309 - (60%)
• Gaps: 55/1309 - (4%)

  Fly    10 KDDVNSRSQYKTNIVLGAKLEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYF 74
            |:|::  ::|..|.   :|..|:..|...:|..|..:|:|.::.                 :...
 Frog    54 KEDMD--TEYAVNT---SKNTDTLLDNAQYETTKENEKNKQEQI-----------------IGPI 96

  Fly    75 QLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNLANDMIDLGGLLESGKSYRADDAISTLL 139
            .:|::|...|..|.:||.|.|:..|...|..:::||.:::..:.....|::..:......|.
 Frog    97 SIFQFADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNSSLQNSSACAKFKPIE--- 158

  Fly   140 LDKVRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVA 204
             :::::|||....:|..:|.|.||.::|:..||..|...:|..||.|:|.|::.|:|..:||::.
 Frog   159 -EEIQKFSLYYAGLGFAVLFCGYLQVSCWVVAASRQTRKMRKAFFHSVLSQEIGWFDVTKSGDLN 222

  Fly   205 SRMNEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATS 269
            :|:.|:::|:.||:.:||..|.......|..:::..::||:|:||.|.:.|:..:|..:.:....
 Frog   223 TRLTENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVILATSPVLTLASAMFSRIVV 287

  Fly   270 RLAKKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLL 334
            .|..||:..||.|..||:..||.||||.||.||.||:..|.|.:..||.:.||:::.|....||:
 Frog   288 SLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENLKQAKDIGIKKSIASQFALGLV 352

  Fly   335 WFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKG 399
            ....||:|.:.||||..||::.      ::|..|.::.|||:|...|..||.||.:.|||.||:.
 Frog   353 NGAFYATYGVGFWYGTTLVLED------DDYTIGDVMAVFFNVSFSSYAIGQAASHFEAFHIARA 411

  Fly   400 ACAKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVAL 464
            |.:.:|.:|:|...|:....:|.|.:.....||.|::.|.||:||.|.:||.|||.:..||||||
 Frog   412 AASSIFKVIKQSSSIDNFSNDGFKPDNIKGNIELKDIYFSYPSRPGVKVLNGLNLSVKSGQTVAL 476

  Fly   465 VGPSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRY 529
            ||.|||||||.:||:||.|||:.|.|..:|.::|.|::.:.|..||||.|||:||.|:|.:||||
 Frog   477 VGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKSLNVTYYRELIGVVSQEPVLFGTTIKQNIRY 541

  Fly   530 GREDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLD 594
            ||:|.|.||||.|...|||..||..||..|:|||||||||||||||||||:||||:|:|:|||||
 Frog   542 GRDDVTDEEIEKAVKEANAYDFIMALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLD 606

  Fly   595 EATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKD 659
            ||||||||.|||.|||||:|...|||||:|||||||:..||.||||:.|.|.|.|||.||||.|.
 Frog   607 EATSALDTGSEAVVQAALDKARKGRTTIVVAHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKG 671

  Fly   660 HYFNLV---TTQLGEDDGSV-LSPTGDIYKNFDI----KDEDEEEIKVLSEDEDEDVMVTDEKNK 716
            .||:|.   |.||.:|:.:. .:..|.||:...:    ..:...:.|:| |||||      |:..
 Frog   672 IYFSLATAQTVQLSDDNETTEKNQNGIIYEKASLIQRFNSQTSLKSKIL-EDEDE------EEES 729

  Fly   717 KKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQ 781
            ||....|.       ..:::|:|:.||..|.:|.|::.::|..:|:|.:.:..|:.:.:..| .:
 Frog   730 KKDLPTVS-------FFQLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAVFASND-PE 786

  Fly   782 YVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGT 846
            .:|:.|:..||.|.:.|:|:.:|...:.|.||.:||.||.|||.:.|:||::|::||||||.|.|
 Frog   787 TIRKESDLCSLIFGLTGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNT 851

  Fly   847 GSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQR 911
            |:|..||:.||:.:|.|||.|:|.:.:::..:.|.:.::..|.|.|.|:.||..||::|...::.
 Frog   852 GALTTRLATDASEIQTATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLAMAPFMVICGLLEF 916

  Fly   912 TLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFRGLV 976
            :.:........|.::...|:|.|.|.||||:.||.||..|.:.|...|......|.|.....||.
 Frog   917 SALTGFATRDKKQLQRAGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNSLRKAQIYGLY 981

  Fly   977 YGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAK 1041
            :.:..:..:|.:||...:|.:.:.:..|...:...|...:..|..::...|.|||:..|..|||:
 Frog   982 FAIGHAFYYFTHAALFCFGAYLIKYERINVEEALLVFSVITFGAMTLGTTLTFAPDYAKATSAAR 1046

  Fly  1042 TIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGP 1106
            .:|.....:|:|.......:.|....|.:.|..|.|:|||||:::||:.|.:.|..||.:|.||.
 Frog  1047 YLFALFESKPAIDSSSQQGQKPDCFSGSLEFRNVSFNYPTRSDVRVLRDLCVKVESGQTVAFVGS 1111

  Fly  1107 SGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDN 1171
            |||||||.:||:|||||..||..|:|:.|.:..::..||:|:|||||||:|||.:|.|||:||||
 Frog  1112 SGCGKSTSVQLLQRFYDPKEGEVLLDDVDAKCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDN 1176

  Fly  1172 ARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDE 1236
            :|.|:..||.||.|.:|||.||..|||.|:|.:|.||.||||||||||||||||||.|||:||||
 Frog  1177 SRTVSMDEIQSAAKAANIHSFIEGLPLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDE 1241

  Fly  1237 ATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGL 1301
            ||||||.|||||||.|||.|.:|||.|.|||||:||.::|:|.|...|.:.|.|.|::|||..|.
 Frog  1242 ATSALDNESEKVVQQALDQARKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGA 1306

  Fly  1302 YYTLYKLQS 1310
            ||.|...|:
 Frog  1307 YYDLVNAQA 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	533/1246 (43%)
		ABC_membrane	92..382	CDD:279056	91/289 (31%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	154/239 (64%)
		ABC_membrane	750..1020	CDD:279056	84/269 (31%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	144/238 (61%)
abcb5	XP_031759158.1	PTZ00265	164..1311	CDD:240339	518/1167 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3111
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1029	1.000	Inparanoid score	I275
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm47420
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070