DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr50 and Mdr49

DIOPT Version :9

Sequence 1:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster
Sequence 2:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster


Alignment Length:1311 Identity:559/1311 - (42%)
Similarity:813/1311 - (62%) Gaps:62/1311 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109
            |::|:..::.....::||.. :..::.|||.||||:|:.:|.|.|:.||.|.|.....|...:|:
  Fly     4 KEESRLPQAGDFQLKEGSVV-DATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67

  Fly   110 GNLANDMID----------------LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIML 158
            |...:.::|                .||..:...:.:.::  :..::|....|.:.:....:.|.
  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEEN--NQAIIDDATAFGIGSLVGSVAMF 130

  Fly   159 VCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVV 223
            :...|:|...|..|.:||..||..|..::|.||:.|||.:.....||:|.|||.|:::|:.||:|
  Fly   131 LLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIV 195

  Fly   224 MFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEG 288
            :.|..::.||..:|.|||.||:|:||.|:.:|....|..:||.....||:||:..|:.||.|.|.
  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260

  Fly   289 ALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLV 353
            ..||||||.||.|:.||...:.:.::.|:....|:.::||:|..|.|..||...|||.||||.|:
  Fly   261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325

  Fly   354 IKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPID 418
            :.....|. ..|....::.|.|:|:||:.|:|.|:|::||..:|..|...:|:||::..:::|:|
  Fly   326 LDERDLPD-RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389

  Fly   419 GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFY 483
            .:|.:.......|.|:.:.|:||.||:|.||..|.:.:..|||||.||.|||||||.|||:||||
  Fly   390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFY 454

  Fly   484 DPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANA 548
            ||:||::..:|.:|:.|::.||||:||||||||:||||:|.|||||||..||:.:||.||.|||.
  Fly   455 DPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANC 519

  Fly   549 AIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALE 613
            ..||.:|||||||.|||:|||:||||||||||||||:|.|::|||||||||||..||.:||:|||
  Fly   520 HDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALE 584

  Fly   614 KVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVT-TQLGE----DD 673
            ..|.|.||::|||||||:..||:||.:..|.|.|.|||:||||.:..|..||: ||..|    |:
  Fly   585 LASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADE 649

  Fly   674 GSVLSPTGDIYKNFDIKDE---DEEEIKVLSEDEDEDVMV--------------TDEKNKKKKKK 721
            |:|..  ..:.|:.::.||   |:||    .|:|||:..:              |..|.:.:::|
  Fly   650 GAVAG--RPLQKSQNLSDEETDDDEE----DEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRK 708

  Fly   722 KVKDPNEVKPM--LEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVR 784
            |.||...|..:  .::||:|.|||..|.||.|:||:.|...|::.:.||....|||..|:| .||
  Fly   709 KKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDD-VVR 772

  Fly   785 ENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSL 849
            ....:.|:.|:..|::.|:...||.|.|..||.::|.|||...|..::.|::|:|||:.|..|:|
  Fly   773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGAL 837

  Fly   850 CARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLM 914
            |:||:.|.:.||||||.|:||::|:::||.:|:.:...:.|...|:.|...|.:.::.|::...:
  Fly   838 CSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFI 902

  Fly   915 AKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEIS-KRNTHFRGLVYG 978
            .|....:..::|..:::|||.::|||||..|..|......|: ..|..|:|: :|...|||||:.
  Fly   903 MKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYV-QQIDRVDIACRRKVRFRGLVFA 966

  Fly   979 LARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTI 1043
            |.::..|.||...||||...|....:.:.|:.||::|||.|:..:..|||:|||:...:.:|..:
  Fly   967 LGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRL 1031

  Fly  1044 FTFLRRQPSIVDRPGVSRDPWH----SEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALV 1104
            ....:|..:   :|...:.|::    |||.:.::.|.|.||||....:|:||.|.:.|...:|||
  Fly  1032 MDLFKRTST---QPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093

  Fly  1105 GPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYG 1169
            ||||.|||||:||:.|:||...|:..:.........:..||::||:|||||:||||||.|||:||
  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158

  Fly  1170 DNAR-NVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIML 1233
            :|.| :|:.||||.|.||||||.||:.||.|||||:| |.:||||||||||||||||:|||||::
  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILI 1222

  Fly  1234 LDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN 1298
            |||||||||.|||||||.|||.|..|||.::|||||:||.::|:|.|.:.|:|.|.|.|.:|:|.
  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287

  Fly  1299 RGLYYTLYKLQ 1309
            ..:|..||.:|
  Fly  1288 NKIYANLYLMQ 1298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 554/1284 (43%)
ABC_membrane 92..382 CDD:279056 100/305 (33%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 149/237 (63%)
ABC_membrane 750..1020 CDD:279056 96/270 (36%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 138/239 (58%)
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 271/608 (45%)
ABC_membrane 116..352 CDD:279056 88/236 (37%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 147/233 (63%)
MdlB 735..1299 CDD:224055 252/570 (44%)
ABC_membrane 739..998 CDD:279056 91/260 (35%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 138/239 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I1905
eggNOG 1 0.900 - - E2759_KOG0055
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 876 1.000 Inparanoid score I60
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - P PTHR24221
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
1211.910

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