DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and ABCB5

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1311	Identity:	525/1311 - (40%)
Similarity:	777/1311 - (59%)	Gaps:	85/1311 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LEDSDRDRKSFEPNKSKKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLL 93
            :|:|:| .:..:.|..:..:..::.....|..||           .::||:|...|..|.::|:|
Human     1 MENSER-AEEMQENYQRNGTAEEQPKLRKEAVGS-----------IEIFRFADGLDITLMILGIL 53

  Fly    94 SAVATGLTTPANSLIFGNLANDMIDLGGLLESG-KSYRADDAISTLLLDKVRQFSLQNTYIGIIM 157
            :::..|...|...|:.|.:::::|. |.|:::. .:|:........|.:.:...:|....||:..
Human    54 ASLVNGACLPLMPLVLGEMSDNLIS-GCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAA 117

  Fly   158 LVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKV 222
            |:..|:.|:.:...|..|...||.:||.|:|.||:.|:|....||:.:||.:|:.|:.||:.:|:
Human   118 LIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKI 182

  Fly   223 VMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSR----LAKKEVTMYAGAA 283
            .:....:..|...|.:..||||:|:||.|::.||...:    |.|.||    |..||::.|:.|.
Human   183 ALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMAS----AAACSRMVISLTSKELSAYSKAG 243

  Fly   284 VVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWY 348
            .|||..||.||||.||..:.||:..|.:.:..||...|||.:.|.:..|.::||:..:|.|||||
Human   244 AVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNGTYGLAFWY 308

  Fly   349 GVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPE 413
            |..|::.|  ||   .|..||::.|||||:..|..||.|.|:.|.|.||:||...:|.:|::.|.
Human   309 GTSLILNG--EP---GYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPS 368

  Fly   414 INPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQL 478
            |:.....|.|......|:|||.|.|.||:||.:.||..|||:|..|:||||||.:|.||||.:||
Human   369 IDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQL 433

  Fly   479 VQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAA 543
            :||.|||..|.::.:..:::.|::...|..||||.|||:||.|:|..||:|||:|.|.||:|.||
Human   434 LQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAA 498

  Fly   544 AAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKV 608
            ..|||..||.:.|..::|||||:|||:||||||||||||||:|:|:||:|||||||||:.|::.|
Human   499 REANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 563

  Fly   609 QAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDD 673
            ||||||.|.|||||:|||||||:|.||.||.:..|.:.|.|.|.|||..:..|::||.:|
Human   564 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ----- 623

  Fly   674 GSVLSPTGDIYKNFDIKDEDEE------------------EIKVLSEDEDEDVMVTDEKNKKKKK 720
                          |||..||:                  .:|.:..|      ..|:..:..:.
Human   624 --------------DIKKADEQMESMTYSTERKTNSLPLHSVKSIKSD------FIDKAEESTQS 668

  Fly   721 KKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQ-YVR 784
            |::..| ||. :|:::|:|||||..:.:|.::||:.|...|:|:::|..|:.:..  :||: .::
Human   669 KEISLP-EVS-LLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFG--NNDKTTLK 729

  Fly   785 ENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSL 849
            .::..||:.|:|.|::..::.|:|..|:|.|||.||.|||.|.|:|||.|::||||:|.|.||.|
Human   730 HDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGL 794

  Fly   850 CARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLM 914
            ...|:.|.|.:|||||.|||.:.|:.:.:.|.:.:|..|.|.:..:.|:..|.:.:...::...|
Human   795 TTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAM 859

  Fly   915 AKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHFR----GL 975
            ........:.:::..|:|.|.:.||||:.||.||:.|.|.|..||    :...|||..:    |.
Human   860 TGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEML----QTQHRNTSKKAQIIGS 920

  Fly   976 VYGLARSLMFFAYAACMYYGTWCVIHRGILFGD-VFKVSQALIMGTASIANALAFAPNMQKGVSA 1039
            .|..:.:.::|||||...:|.: :|..|.:..: :|.|..|:..|..:|...|..||...|..|.
Human   921 CYAFSHAFIYFAYAAGFRFGAY-LIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSG 984

  Fly  1040 AKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALV 1104
            |..:|..|.::|:|..|....:.|...||.:.|.:|.|.||.|.::.:|:||.|::.:|:.:|.|
Human   985 AAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFV 1049

  Fly  1105 GPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYG 1169
            |.|||||||.:||:||.||..:|..|.|..|.:.:::..||:|:.||.|||:||:.:|.|||:||
Human  1050 GSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYG 1114

  Fly  1170 DNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLL 1234
            ||:|.|...||..|...:|||.||..||..|:|::|.||||||||||||:||||||::.|||:||
Human  1115 DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLL 1179

  Fly  1235 DEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANR 1299
            ||||||||.:||||||.|||.|..|||.:.:.||||.:.::|:|.|..||.:.|.|.|::||.||
Human  1180 DEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 1244

  Fly  1300 GLYYTLYKLQS 1310
            .:|:.|...||
Human  1245 DIYFKLVNAQS 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	516/1267 (41%)
		ABC_membrane	92..382	CDD:279056	100/294 (34%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	137/236 (58%)
		ABC_membrane	750..1020	CDD:279056	92/275 (33%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	126/238 (53%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/23 (17%)
		PTZ00265	8..1251	CDD:240339	519/1297 (40%)
		ABC_membrane	52..333	CDD:279056	99/290 (34%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	137/236 (58%)
		ABC_membrane	696..962	CDD:279056	92/272 (34%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	126/237 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2842
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1026	1.000	Inparanoid score	I275
Isobase	1	0.950	-	0	Normalized mean entropy	S1571
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm40248
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.730