DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and Abcb11

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_001350421.1	Gene:	Abcb11 / 27413	MGIID:	1351619	Length:	1321	Species:	Mus musculus

Alignment Length:	1326	Identity:	525/1326 - (39%)
Similarity:	775/1326 - (58%)	Gaps:	83/1326 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KSKKKSKHD----ESDASDEEDGSQYHEDVK-----QVSYFQLFRYATKKDRALYVIGLLSAVAT 98
            :|.||...:    |||.....|.....:|.|     :|.:|:|||:::.||..|..:|.:.|:..
Mouse     8 RSVKKFGEENHAFESDGFHNNDKKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLH 72

  Fly    99 GLTTPANSLIFGNLANDMIDLG------------------GLLESGKSYRADDAISTLLLD---K 142
            |:..|...::||.|.:..::..                  ..:.|..:....:..|..|:|   :
Mouse    73 GMAQPGMIIVFGILTDIFVEYDIERQELSIPEKVCMNNTIVWINSSFNQNMTNGTSCGLVDINSE 137

  Fly   143 VRQFSLQNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRM 207
            |.:||.....:|:.:|:..|..|..:......||..:|..:||.|:..::.|:|....||:.||.
Mouse   138 VIKFSGIYAGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRF 202

  Fly   208 NEDLSKMEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLA 272
            ::|::|:::.:|:::.:|:..|...:..|:|.|.:||:|:||.|...||..|...::.::.::..
Mouse   203 SDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFT 267

  Fly   273 KKEVTMYAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFF 337
            :.|:..||.|..:|:..||.||||.||.||.|||..|::.::.|:...|.:.|..|...|.:|..
Mouse   268 ELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCL 332

  Fly   338 IYASYALAFWYGVGLVI-KGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGAC 401
            |:..||||||||..||: :|.:.|       ||:|.:|..|::.:||||.|:..:|.|.....|.
Mouse   333 IFFCYALAFWYGSRLVLDEGEYTP-------GTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAA 390

  Fly   402 AKVFHIIEQIPEINPIDGEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVG 466
            :.:|..|::.|.::.:.|:|.||:.....|||..|.|.||:||||.|||.|::.|..|:|.|.||
Mouse   391 SSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVG 455

  Fly   467 PSGCGKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGR 531
            .||.||||.:||:||||||..|.:..:|.:::.|:|.|||.:||:|.|||:||:|:|.||||.||
Mouse   456 SSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGR 520

  Fly   532 EDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEA 596
            |:||.|:|..||..|||..||..||:.:||||||.|.|:|||||||:||||||||.|:|||||.|
Mouse   521 EEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMA 585

  Fly   597 TSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHY 661
            |||||..||||||.||.|:..|.|.|.|||||||||.||.|:....|..||.|||:||:|.|..|
Mouse   586 TSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVY 650

  Fly   662 FNLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEE--------------------IKVLSEDE-- 704
            |.|||.|..||         :.:|...||.:|..|                    |:..|:.:
Mouse   651 FMLVTLQSQED---------NTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLS 706

  Fly   705 ----DEDVMVTDEKNKKKKKKK---VKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPI 762
                :..:.:.|.|:..:.:|.   :.:..|..|:..::|.|..||..|.||.:.:.|.|...||
Mouse   707 HLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPI 771

  Fly   763 FAVLFGSILQILSVKDNDQYVRENSNQYS--LYFLIAGIVVGIATFLQIYFFGIAGERLTERLRG 825
            :::||..||:..|:.|.:|   :.|..||  |:|:|.|.|.....|||.|.|..:||.||:|||.
Mouse   772 YSLLFSQILKTFSLVDKEQ---QRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRK 833

  Fly   826 LMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEW 890
            ..|:|||||::.||||..|..|.|..||:.||:.||||||.::|.:|.|.:.:.:.:.::..:.|
Mouse   834 FGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNW 898

  Fly   891 SLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNY 955
            .|.||...|.||:.::..:|..::........:.:|...::..|.:|||||||.:|.|..|.:.:
Mouse   899 KLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAF 963

  Fly   956 IGMLIPAVEISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGT 1020
            ...|..:.:.:.|..:..||.|..::.:.|.|.:|...||.:.:::..:.|..||:|..::.|..
Mouse   964 EVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSA 1028

  Fly  1021 ASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHS-EGYVRFDKVKFSYPTRSE 1084
            .::....::.|:..|...:|...|..|.|:|.|....|.. :.|.: :|.:.|...||:||:|.:
Mouse  1029 TAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAG-EKWDNFQGKIDFIDCKFTYPSRPD 1092

  Fly  1085 IQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLG 1149
            ||||.||.::|..||.:|.||.|||||||.|||::||||.|:|..:||..|.:.|::..||:.:|
Mouse  1093 IQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQFLRSNIG 1157

  Fly  1150 IVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGG 1214
            ||||||:|||.:|.:||.||||.:.::.:..|:|.|::.:|:|:.:||..|:|.:|.:|:|||.|
Mouse  1158 IVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRG 1222

  Fly  1215 QKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIF 1279
            :|||||||||::|:|||:||||||||||.||||.||.|||.|.||||.|.|||||||:.:||:|.
Mouse  1223 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIA 1287

  Fly  1280 VFENGLVCEAGDHKQLLANRGLYYTL 1305
            |...|:|.|.|.||:|:..:|.||.|
Mouse  1288 VMSQGVVIEKGTHKKLMDQKGAYYKL 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	517/1296 (40%)
		ABC_membrane	92..382	CDD:279056	89/311 (29%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	146/236 (62%)
		ABC_membrane	750..1020	CDD:279056	92/271 (34%)
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216	132/236 (56%)
Abcb11	NP_001350421.1	AAA	29..1314	CDD:333001	519/1305 (40%)
		Interaction with HAX1. /evidence=ECO:0000250	651..674		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..722		9/59 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	206	1.000	Domainoid score	I2901
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1050	1.000	Inparanoid score	I261
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		otm42316
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800