DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr50 and mdl1

DIOPT Version :9

Sequence 1:	NP_523740.3	Gene:	Mdr50 / 36582	FlyBaseID:	FBgn0010241	Length:	1313	Species:	Drosophila melanogaster
Sequence 2:	NP_595751.1	Gene:	mdl1 / 2541285	PomBaseID:	SPBC9B6.09c	Length:	726	Species:	Schizosaccharomyces pombe

Alignment Length:	716	Identity:	222/716 - (31%)
Similarity:	361/716 - (50%)	Gaps:	96/716 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TVKNGDVVKDDVNSRSQYKTNIVLGAKLEDSDRD-----RKSFEPNKS----KKKSKHDESDASD 57
            |.|....|...:||.||..::   |:|:......     .:|..|.:|    |...:|:.:..|.
pombe    58 TSKLSSQVNVSLNSLSQKASS---GSKIYPFKNSFPLPFSRSILPIRSLAFLKLCVRHNSTVPSK 119

  Fly    58 EEDGSQYHEDV-------------KQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109
            :|..    :|:             |:|:.|:||..|..:....::.|.|..|::|:|.....::
pombe   120 DEQA----QDISKINTNGTLQTPNKKVNVFRLFTLARGQGWNFFIAGSLLLVSSGVTMSIPYIV- 179

  Fly   110 GNLANDMIDLGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIML-----VCSYLSITCFN 169
                      |.:|::|.|  .|.:::.::......|     |||::.|     .|::..|....
pombe   180 ----------GKILDAGSS--GDSSVTHIMGIPSGTF-----YIGLLGLFFLGSACNFGRIITLR 227

  Fly   170 YAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLS--------KMEDGLAEKVVMFV 226
            ..:...:..:|::.|...:..|..::||::.|::.||:..|.|        .:.|||...|
pombe   228 LLSERIVSRLRARLFAKCMSLDGAFFDFHKHGDLISRLTTDSSIVGKSLSMYLSDGLRSSV---- 288

  Fly   227 HYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMG--LVAVATSRLAKKEVTMYAGAAVVAEGA 289
               .|..|..::.:|   .:.|....||.:..||:|  .......:|::...........|:|..
pombe   289 ---SAIAGIGMMLYV---SMRLTGYMSLIVPPIALGAFFYGEYVRKLSRTTQDALGDLTRVSEEK 347

  Fly   290 LSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMF-SGIGFGLLWFFIYASYALAFWYGVGLV 353
            |:.:||.:||.||.:||..|.:.:....:| .||..| |||.||...|...|:.......|..:|
pombe   348 LANVRTTQAFLGERQEVNRYNDYIRNLFVL-AKREAFASGIFFGSTGFLGNATVIAILALGGRMV 411

  Fly   354 IKGYHEPAYENYDAGTMIT-VFFSVMMGSMNIGMAAPYIEAF-GIAKGACAKVFHIIEQIPEINP 416
            ..|       :...|.:.: :.::|..|...:|::..:.:.. |:  ||.:::|.:::..|:|.|
pombe   412 AAG-------DITVGQLSSFLLYTVYAGGSIVGLSGCFTDIMKGL--GAASRLFELLDAKPKIAP 467

  Fly   417 IDGEGKKLNEPLTT----IEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQ 477
            ..|    :..|:|.    :.|:.|.|.|||||..||.:.|:..||.|..||:|.|||.||||..|
pombe   468 TVG----IPVPVTVGKAILSFRNVGFAYPTRPSASIFDNLSFDIHPGTNVAIVAPSGGGKSTISQ 528

  Fly   478 LVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAA 542
            |:.|||.|.:|.:|.:|.::...:::..||..|:|||||:||:.:|.|||.||:.:|::||||.|
pombe   529 LLLRFYAPSSGKILADGVDISTYNVHQWRSHFGLVGQEPVLFSGTIGENIAYGKSNASQEEIEDA 593

  Fly   543 AAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAK 607
            |..||.: |:...|:.:.|.||.||.||||||||||||||||:|:|..|:|||||||||..:|..
pombe   594 AKRANCS-FVLSFPEKWSTQVGTRGLQLSGGQKQRIAIARALLRNPAFLILDEATSALDGEAEVM 657

  Fly   608 VQAALEKVSAGR--TTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLG 670
            |...::.:...|  |||.:||:|:|:||||:|:|:..|:|:|.|:.:.|.....:::.|:..|||
pombe   658 VDKTIQSLMHNRSMTTITIAHKLATIRRADQIIVVGDGKVLEQGSFERLSRPGTNFYKLMRWQLG 722

  Fly   671 E 671
            :
pombe   723 K 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	205/627 (33%)
		ABC_membrane	92..382	CDD:279056	69/306 (23%)
		ABC_MTABC3_MDL1_MDL2	431..668	CDD:213216	115/238 (48%)
		ABC_membrane	750..1020	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1070..1309	CDD:213216
mdl1	NP_595751.1	MdlB	141..723	CDD:224055	203/624 (33%)
		ABC_membrane	164..430	CDD:279056	67/301 (22%)
		P-loop_NTPase	484..720	CDD:304359	115/236 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I938
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810